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Texas Heart Institute and 7 Hills Pharma receive $1.9 million to improve stem cell transplants

The Texas Heart Institute and 7 Hills Pharma received a $1.9 million, Phase II STTR (R42) grant from the National Heart Lung Blood Institute to advance further their lead product 7HP349, a novel integrin activator, to define the optimal dosing schedule for cord blood transplant along with a focus on development and production of a formulation that meets safety standards for filing an IND application with the FDA.

12 Jun 2020

Drug-like molecules offer a promising treatment for COVID-19

A team of researchers at the University of Georgia has successfully demonstrated that a set of drug-like small molecules can block the activity of a key SARS-CoV-2 protein - providing a promising path for new COVID-19 therapeutics.

12 Jun 2020

Researchers identify link between methylation and the body's circadian rhythms

Every second of every day, countless biochemical reactions take place in our bodies' cells. The organization of this complex system is the result of billions of years of evolution, fine-tuning our functions since the first primordial organisms.

12 Jun 2020

Type III interferons can increase risk of bacterial "superinfections" in the lung, research shows

Interferons and other cytokines produced by the immune system are important defenses against viral infections, but as we have seen in COVID-19, they can also contribute to damaging, potentially life-threatening lung inflammation.

12 Jun 2020

Scientists develop a lead compound to fight chemotherapy-resistant prostate cancer

Scientists of Far Eastern Federal University, together with German and Russian colleagues, have developed a lead compound to fight chemotherapy-resistant prostate cancer.

12 Jun 2020

A protein that helps treat viruses can later interfere with lung tissue repair

Researchers at the Francis Crick Institute have found that a protein which is initially helpful in the body’s immune response to a virus, can later interfere with the repair of lung tissue.

12 Jun 2020

Researchers question the mechanism of retinitis pigmentosa

Researchers who made a knock-in mouse-model of the genetic disorder retinitis pigmentosa 59, or RP59, expected to see retinal degeneration and retinal thinning. As reported in the journal Cells, they surprisingly found none, calling into question the commonly accepted -- though never proved -- mechanism for RP59.

12 Jun 2020

Engineered natural killer cells show promise for treating a form of leukemia

Using induced pluripotent stem cells (iPSCs) and deleting a key gene, researchers at University of California San Diego School of Medicine have created natural killer cells - a type of immune cell - with measurably stronger activity against a form of leukemia, both in vivo and in vitro.

12 Jun 2020

New computational system to understand how the brain works

Accelerating progress in neuroscience is helping us understand the big picture--how animals behave and which brain areas are involved in bringing about these behaviors--and also the small picture--how molecules, neurons, and synapses interact.

11 Jun 2020

Researchers use human stem cell models to analyze degeneration in glaucoma

More than 3 million Americans have glaucoma, a serious eye condition causing vision loss. Using human stem cell models, researchers at Indiana University School of Medicine found they could analyze deficits within cells damaged by glaucoma, with the potential to use this information to develop new strategies to slow the disease process.

11 Jun 2020

Neural circuits that control hibernation-like behaviors discovered in mice

The dream of suspended animation has long captivated the human imagination, reflected in countless works of mythology and fiction, from King Arthur and Sleeping Beauty to Captain America and Han Solo.

11 Jun 2020

UNC scientists develop new kind of antibody test for COVID-19

As the COVID-19 pandemic continues with many thousands of new infections reported each day, there is a need for widely applicable surveillance testing to gain a better understanding of infection rates, especially the number of infections in people with mild or no symptoms, who can still be carriers.

11 Jun 2020

COVID-19 poses a global threat to the entire nervous system

A new review of neurological symptoms of COVID-19 patients in current scientific literature reveals the disease poses a global threat to the entire nervous system, reports a Northwestern Medicine study published this week in Annals of Neurology.

11 Jun 2020

Treatment with vitamin A analog improves visual function in diabetic mice

Diabetic retinopathy is a common complication of diabetes and a leading cause of blindness among the working-age population.

11 Jun 2020

Strength training increases muscle strength and size in patients with cirrhosis

Three hours of weekly strength training combined with protein supplements leads to both bigger and stronger muscles in patients with cirrhosis. This is shown by a new study from Aarhus University and Aarhus University Hospital.

11 Jun 2020

Nutritional study shows wide range of metabolic responses after eating in healthy adults

Researchers led by King's College London announced today the first published results from PREDICT, the largest ongoing nutritional study of its kind.

11 Jun 2020

Fish oil may be an effective treatment for depression, study shows

A study published in Molecular Psychiatry shows that patient-derived adult stem cells can be used to model major depressive disorder and test how a patient may respond to medication.

11 Jun 2020

Study: Probiotic derived from Chinese pickles can prevent cavities

Can a probiotic derived from Chinese pickles prevent cavities? That seems to be the case, according to a study by researchers at Ben-Gurion University of the Negev and Chengdu University in China.

11 Jun 2020

Antihypotensive agent for sepsis disrupts the immune system, increases susceptibility to infections

Patients who go into shock caused by sepsis (septic shock) are treated with the antihypotensive agent norepinephrine.

11 Jun 2020

Scientists develop new test to help identify people at risk for developing liver cancer

Scientists have developed a new test that can help identify people who are likely to develop hepatocellular carcinoma (HCC), the most common form of liver cancer. The approach uses a simple blood test to check for the patient's previous exposure to certain viruses.

11 Jun 2020