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Inhibition of a single enzyme may reduce heparin-induced thrombocytopenia

Heparin is widely used as an anticoagulant, but evokes in some patients a potentially life-threatening condition called HIT. Clinical scientists at Ludwig-Maximilians-Universitaet in Munich have now shown that inhibition of a single enzyme may markedly reduce this risk.

21 Dec 2019

Researchers take first step to find causes of sarcopenia

Researchers have gained new insight into the mechanisms involved in how skeletal muscles lose their mass and strength as people age, called sarcopenia.

20 Dec 2019

Kobe scientists develop mathematical model to predict cancer drug side effects

A research team at Kobe University Hospital have further illuminated the likelihood of cancer drug side effects that can occur due to genetic mutations in the drug-metabolizing enzyme.

20 Dec 2019

Researchers locate brain biomarkers for detecting Alzheimer's disease

From the detection of functional brain changes that occur during Alzheimer's Disease, a research team from the Complutense University of Madrid has located a set of biomarkers that could predict which patients with Mild Cognitive Impairment have a higher risk of developing dementia.

20 Dec 2019

Combined datasets can expedite the discovery and development of new cancer drugs

A comprehensive map of genes necessary for cancer survival is one step closer, following the validation of the two largest CRISPR-Cas9 genetic screens in 725 cancer models, across 25 different cancer types.

20 Dec 2019

Links between most human diseases and genetics are shaky at best

In most cases, your genes have less than five per cent to do with your risk of developing a particular disease, according to new research by University of Alberta scientists.

20 Dec 2019

The brain’s temporal lobe is also an attention controlling area, shows study

As you read this line, you're bringing each word into clear view for a brief moment while blurring out the rest, perhaps even ignoring the roar of a leaf blower outside.

19 Dec 2019

Scientists explain how a common virus causes havoc on bone marrow, organ transplant patients

For the first time, scientists have discovered the molecular mechanism behind how a common virus can wreak havoc on bone marrow and organ transplant patients, according to a paper published in the journal Cell & Host Microbe.

19 Dec 2019

Common immune cell linked to failure of checkpoint inhibitors in lung cancer patients

For many lung cancer patients, the best treatment options involve checkpoint inhibitors. These drugs unleash a patient's immune system against their disease and can yield dramatic results, even in advanced cancers.

19 Dec 2019

Fibroblasts involved in healing wounds play a devastating role in breast cancer development

The connective tissue cells known as fibroblasts are vitally important for our recovery from injury. Sensing tissue damage, they gravitate to the site of a wound, instigating an inflammatory response that mends damaged tissue.

19 Dec 2019

Novel 'tooth-on-a-chip' could open door to personalized dental care

A so-called "tooth-on-a-chip" could one day enable more personalized dentistry, giving dentists the ability to identify dental filling materials that work better and last longer based on a patient's own teeth and oral microbiome.

19 Dec 2019

Caffeine may offset some negative health effects of obesogenic diet

A new study in rats suggests that caffeine may offset some of the negative effects of an obesogenic diet by reducing the storage of lipids in fat cells and limiting weight gain and the production of triglycerides.

19 Dec 2019

Experimental Zika vaccine improves fetal outcomes in rhesus macaque model

An experimental Zika vaccine lowered levels of virus in pregnant monkeys and improved fetal outcomes in a rhesus macaque model of congenital Zika virus infection, according to a new study in Science Translational Medicine.

19 Dec 2019

Edematous severe acute malnutrition linked to DNA modification

A group led by researchers at Baylor College of Medicine has identified significant differences at the epigenetic level - the chemical tags in DNA that help regulate gene expression - between two clinically distinct forms of acute childhood malnutrition known as edematous severe acute malnutrition (ESAM) and non-edematous SAM (NESAM).

19 Dec 2019

Powdered watermelon supplements provide health benefits to obese mice

Eating watermelon in the form of powdered supplements helped adult obese mice avoid some detrimental health effects of an unhealthy diet, according to a new Oregon State University study.

19 Dec 2019

Researchers reveal the mystery in replication cycle of hepatitis D virus

A team led by Professor Patrick Labonté at the Institut National de la Recherche Scientifique in Montreal, Canada has identified the role of a key process in the replication cycle of the hepatitis D virus, an infection that is still very difficult to cure and affects 15 to 20 million people worldwide.

19 Dec 2019

Researchers discover a way to move precision immunotherapy forward for multiple myeloma

Researchers at the Icahn School of Medicine at Mount Sinai have discovered a way to move precision immunotherapy forward by using genomics to inform immunotherapy for multiple myeloma, a blood cancer, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research, in December.

19 Dec 2019

Glutamine could help obese people reduce inflammation of fat tissue

Glutamine could help people with obesity reduce inflammation of fat tissue and reduce fat mass, according to a new study at Karolinska Institutet in Sweden and the University of Oxford in the U.K. The researchers also show how glutamine levels can alter gene expression in several different cell types.

19 Dec 2019

Study reveals how circadian rhythm changes the way mammals can see

How mammals perceive light changes between night and day. Researchers at Aalto University and the University of Helsinki discovered that mice were better at finding a dim light in pitch-darkness in experiments done at night time compared to ones done during the day time.

19 Dec 2019

Artificial 'inclusion bodies' developed for sustained release of therapeutic proteins

Precision medicine is becoming increasingly important, achieving to create more efficient personalized therapies for each patient and innovative pharmacological developments.

19 Dec 2019