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Artificial sweetener derivatives show improved activity against tumor-associated enzymes

Saccharin received a bad rap after studies in the 1970s linked consumption of large amounts of the artificial sweetener to bladder cancer in laboratory rats. Later, research revealed that these findings were not relevant to people.

18 Dec 2019

Catastrophic macropinocytosis may aid in cancer treatment

In laboratory experiments, a metabolic inhibitor was able to kill a variety of human cancer cells of the skin, breast, lung, cervix and soft tissues through a non-apoptotic route -- catastrophic macropinocytosis.

18 Dec 2019

OU study explores how menthol's irritant sensation is transmitted by the nervous system

A new University of Oklahoma study could have implications on our understanding of how certain sensory signals are transmitted through the body.

18 Dec 2019

Scientists extract complete human genome from a thousands-of-years old “chewing gum”

It seems that chewing gum is not a new trend! Researchers have found chewing gum that is 5,700 years old and it has provided clues regarding ancient DNA. A study with the findings was published in the journal Nature Communications. It is titled, “A 5,700-year-old human genome and oral microbiome from chewed birch pitch.”

18 Dec 2019

Study opens up new treatment possibilities for Wilms' tumor

As an embryo develops, its cells must learn what to do with the thousands of genes they've been equipped with. That's why each cell comes with a detailed gene-expression manual outlining exactly which genes should be switched on, to what extent, and when.

18 Dec 2019

Aging can be a biggest risk factor for wide range of chronic diseases

Human life expectancy worldwide rose dramatically over the past century, but people's health spans -- the period of life spent free from chronic, age-related disease or disability -- have not increased accordingly.

18 Dec 2019

Research shows harmful effects of chemicals in vaping liquids to lung tissue

New research appearing in the journal Scientific Reports unpacks the list of chemicals that comprise flavored e-liquids and pods used in vaping and details their harmful effects to lung tissue, including inflammation and genetic damage that could indicate long-term risk for respiratory disease and even cancer.

18 Dec 2019

Scientists explore role of IgG4 Abs in IgG4-related disease

Autoimmune diseases are a medical conundrum. In people with these conditions, the immune system of the body, the designated defense system, starts attacking the cells or organs of its own body, mistaking the self-cells for invading disease-causing cells. Often, the cause for this spontaneous dysfunction is not clear, and hence, treatment of these diseases presents a major and ongoing challenge.

18 Dec 2019

Worse long-term control of blood sugar increases risks in diabetic trauma patients

In trauma patients with diabetes, poorer long-term control of blood glucose levels is linked to a higher risk of death and trauma-related complications, reports a study in SHOCK: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches, Official Journal of the Shock Society.

18 Dec 2019

Study provides insight into brain mechanisms underlying compulsive drinking

Compulsive drinking may be due to dysfunction in a specific brain pathway that normally helps keep drinking in check. The results are reported in the journal Biological Psychiatry.

18 Dec 2019

Children with higher BMI tend to have thinner cerebral cortex

Published studies have long found a correlation between obesity in children and decreased executive function. New research published in JAMA Pediatrics, based on data mined from a massive national research study, suggests that a change in brain structure - a thinner prefrontal cortex - may help explain that interrelationship.

18 Dec 2019

Modern wheat does not impair gastrointestinal health in mice compared with heirloom variety

Amid concerns about gluten sensitivity, increasing numbers of people are avoiding wheat. Most have not been diagnosed with a wheat-related medical condition, yet they seem to feel better when they don't eat gluten-containing foods.

18 Dec 2019

Scientists develop computationally inspired method for preclinical study of anxiety

Nearly 40 million people in the U.S. have an anxiety disorder. While treatment options exist, treatment success varies, and many people do not respond to treatment until weeks or months after they begin anti-depressants

18 Dec 2019

IU scientists discover that beta-carophyllene improves wound healing

Indiana University researchers have discovered that a chemical compound found in essential oils improves the healing process in mice when it is topically applied to a skin wound -- a finding that could lead to improved treatments for skin injuries in humans.

18 Dec 2019

Aarhus University professor receives grant to develop a new form of cell therapy

Associate Professor Menglin Chen has received a major grant from the Carlsberg Foundation to develop a completely new method of regenerating brain and heart cells.

18 Dec 2019

Yale researchers identify cellular chicanery that jumpstarts cancer

The progression of cancer has been studied extensively, and the key steps in this journey have been well mapped, at least in some solid tumors: Lesions to genes that confer risk of cancer accumulate and alter normal cell behaviors, giving rise, scientists believe, to early stage cancer cells that eventually swamp normal cells and become deadly.

18 Dec 2019

High fat diet limits birth and development of new neurons in female mice

A high fat diet limits the birth and growth of new neurons in adult female, but not male, mice, according to new research published in eNeuro. Further research could inspire metabolism-based preventions and treatments for brain disorders.

From Society for Neuroscience 18 Dec 2019

Recognizing and drawing an object engage the brain in similar ways

Drawing an object and naming it engages the brain in similar ways, according to research recently published in JNeurosci. The finding demonstrates the importance of the visual processing system for producing drawings of an object.

From Society for Neuroscience 18 Dec 2019

U-M receives $20 million gift to support research and development of life-saving therapies

The University of Michigan has received a $20 million gift from the Maxine and Stuart Frankel Foundation of Bloomfield Hills, Michigan, to support the research and development of life-saving therapies at Michigan Medicine in collaboration with other institutions.

18 Dec 2019

A new function identified for glycine receptors during embryonic development

Glycine receptors are one of the most widely distributed inhibitory receptors in the central nervous system and have important roles in a variety of physiological processes.

18 Dec 2019

Medical Science News

Artificial sweetener derivatives show improved activity against tumor-associated enzymes

Catastrophic macropinocytosis may aid in cancer treatment

OU study explores how menthol's irritant sensation is transmitted by the nervous system

Scientists extract complete human genome from a thousands-of-years old “chewing gum”

Study opens up new treatment possibilities for Wilms' tumor

Aging can be a biggest risk factor for wide range of chronic diseases

Research shows harmful effects of chemicals in vaping liquids to lung tissue

Scientists explore role of IgG4 Abs in IgG4-related disease

Worse long-term control of blood sugar increases risks in diabetic trauma patients

Study provides insight into brain mechanisms underlying compulsive drinking

Children with higher BMI tend to have thinner cerebral cortex

Modern wheat does not impair gastrointestinal health in mice compared with heirloom variety

Scientists develop computationally inspired method for preclinical study of anxiety

IU scientists discover that beta-carophyllene improves wound healing

Aarhus University professor receives grant to develop a new form of cell therapy

Yale researchers identify cellular chicanery that jumpstarts cancer

High fat diet limits birth and development of new neurons in female mice

Recognizing and drawing an object engage the brain in similar ways

U-M receives $20 million gift to support research and development of life-saving therapies

A new function identified for glycine receptors during embryonic development

Obesity, GLP-1s, and metabolic care

Automation in cell-based workflows

Data management challenges in scientific research

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