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New model creates a realistic picture of how vesicles support synaptic transmission

How do we think, feel, remember, or move? These processes involve synaptic transmission, in which chemical signals are transmitted between nerve cells using molecular containers called vesicles.

28 May 2025

Therapeutic plasma exchange combined with intravenous immunoglobin reduces biological age

A first-of-its-kind clinical trial clinical trial shows that therapeutic plasma exchange (TPE) combined with intravenous immunoglobin reduced biological age on average by 2.6 years, as measured by multi-omic biomarkers.

28 May 2025

Study combines biology and mathematics to reveal new insights into cell migration

Imagine cells navigating through a complex maze, guided by chemical signals and the physical landscape of their environment.

28 May 2025

Decade-long brain study offers new insights into aging

Researchers from The University of Texas at Dallas' Center for Vital Longevity (CVL) have released the full dataset from a decade-long project designed to track brain and cognitive health as people age and distinguish neurologically healthy paths from those indicating a likelihood of decline.

28 May 2025

Ghrelin receptor identified as key to easing constipation in Parkinson’s patients

Considered the natural "hunger hormone", Ghrelin could be the key to preventing debilitating chronic constipation experienced by people living with Parkinson's disease, University of Queensland researchers have found.

28 May 2025

Alcohol abuse drug may mitigate trauma-induced damage, especially in females

Runaway cell death and inflammation triggered by severe trauma may be interrupted by a drug used to prevent alcohol abuse – and it may be particularly effective in females, according to new research led by University of Pittsburgh School of Medicine surgeon-scientists and published today in Science Translational Medicine.

28 May 2025

Cancer drug combo extends the lifespan of mice by 30%

The combination of two cancer drugs, rapamycin and trametinib, can extend the lifespan of mice by 30%, according to a study led by researchers at UCL and the Max Planck Institute for Biology of Ageing, Germany.

28 May 2025

Study sheds new light on how caffeine can impair sleep and memory recovery

Caffeine is not only found in coffee, but also in tea, chocolate, energy drinks and many soft drinks, making it one of the most widely consumed psychoactive substances in the world.

28 May 2025

Stress granules play a protective role against neurodegenerative disease

Scientists from St. Jude Children's Research Hospital and Washington University in St. Louis report mechanistic insights into the role of biomolecular condensation in the development of neurodegenerative disease.

28 May 2025

High fat diet disrupts metabolism and increases disease risk

Consuming a high-fat diet can lead to a variety of health problems - not only weight gain but also an increased risk of diabetes and other chronic diseases.

28 May 2025

Basal ganglia neurons precisely regulate complex movement timing

Neurons deep in the brain not only help to initiate movement-they also actively suppress it, and with astonishing precision.

28 May 2025

Scientists identify early life opportunity for in vivo stem cell gene therapy

A team of scientists from the San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget) in Milan, Italy, has identified a unique window shortly after birth in which circulating blood stem cells can be effectively targeted with gene therapy directly in the body.

28 May 2025

ISSCR and Harvard launch free online course on stem cell medicine

The International Society for Stem Cell Research (ISSCR) announces the launch of a new online continuing education course, Stem Cell Medicine: From Scientific Research to Patient Care.

28 May 2025

Intestinal bacteria and their metabolites contribute directly to vascular aging

The aging of the innermost cell layer of blood vessels leads to cardiovascular diseases. Researchers at UZH have now shown for the first time that intestinal bacteria and their metabolites contribute directly to vascular aging.

28 May 2025

NCCN recognizes 2025 awardees for advancing global cancer care

The National Comprehensive Cancer Network (NCCN) announces 2025 awardees who go above and beyond to define and advance quality, effective, equitable, and accessible cancer care and prevention so all people can live better lives.

28 May 2025

Immune microRNAs drive new frontiers in cardiovascular disease research

Cardiovascular diseases (CVDs) continue to dominate global mortality statistics, with immune dysregulation emerging as a central feature in their pathogenesis.

28 May 2025

New biomarkers could help improve detection and treatment of gastrointestinal diseases

Scientists have discovered a range of 'biomarkers' that could help to improve detection and treatment of gastrointestinal diseases (GIDs) such as gastric cancer (GC), colorectal cancer (CRC), and inflammatory bowel disease (IBD).

28 May 2025

Circadian rhythms show seasonal sensitivity in modern humans

It’s tempting to think that, with our fancy electric lights and indoor bedrooms, humanity has evolved beyond the natural influence of sunlight when it comes to our sleep routines.

28 May 2025

Combination of trametinib and rapamycin extends lifespan in mice

The researchers were able to show that Trametinib alone extends the lifespan of mice by 5-10%, while Rapamycin alone increases lifespan by 15-20%. Together, the drugs have a combinatorial effect that extends the life of the mice by around 30%.

28 May 2025

Researchers develop bioactive peptide with therapeutic and regenerative potential

Since the COVID-19 pandemic, global interest in antiviral therapies has increased significantly. Recently, with the growing attention to peptide-based drugs such as Wegovy, demand for effective peptide therapeutics derived from natural substances is rapidly rising.

28 May 2025