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Key metabolic enzyme fuels molecular machinery to turn on memory genes after learning

Understanding how memories are made, retrieved, and eventually fade over a lifetime is the stuff of poems and song. To medical researchers, solving the mysteries of memory is even more elusive.

1 Jun 2017

Study reveals key role of gut microbiota in treatment with classic diabetes medication

A clearer picture of how the classic diabetes medication metformin works has emerged. A recent study at Sahlgrenska Academy and University of Girona indicates that the clinical effect - control of blood glucose - is achieved through modulation of the gut microbiota.

1 Jun 2017

Researchers uncover new way to enhance function of immune cells to combat multiple myeloma

Researchers from Belgium led by Prof. Dirk Elewaut of the VIB-UGent Center for Inflammation Research and the team of Prof. Vanderkerken and Prof. Menu at the Hematology and Immunology lab of the VUB uncovered a new way to enhance the function of a specific type of immune cell that destroys tumors in multiple myeloma, a form of bone marrow cancer considered incurable.

1 Jun 2017

Cholesterol shown to have clear effect on lung surface properties

Cholesterol, a naturally occurring compound at the lung surface, has been shown to have a clear effect on the properties of this nanoscale film that covers the inside of our lungs.

1 Jun 2017

Researchers gain new insights into factors crucial for STIM1 activation

Triggered by decreases in ER Ca2+ level, conformational changes of the endoplasmic reticulum (ER) luminal domain in STIM1 would switch on its cytoplasmic domain (CT) to engage and gate ORAI channels on plasma membrane, resulting in Ca2+ influx.

1 Jun 2017

Scientists identify 100 genes that provide new entry points into understanding human memory

Scientists have identified more than 100 genes linked to memory, opening new avenues of research to better understand memory processing in the human brain.

1 Jun 2017

New method combines organoid technology with bioengineering to build better brains

A few years ago, Jürgen Knoblich and his team at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) have pioneered brain organoid technology. They developed a method for cultivating three-dimensional brain-like structures, so called cerebral organoids, in a dish.

1 Jun 2017

Single protein allows mycobacteria to generate diverse populations and avoid TB drugs, research shows

Subgroups of tuberculosis (TB)-causing bacteria can persist even when antibiotics wipe out most of the overall population. The need to eliminate these persistent subpopulations is one reason why TB treatment regimens are so lengthy.

1 Jun 2017

Researchers discover molecular signaling circuit that regulates autophagy

Autophagy is the recycling process by which our cells keep themselves young. They continually break down and renew small parts of themselves in a kind of self-digestion; this helps to counteract harmful deposits which may form.

1 Jun 2017

Repeated exposure to anesthesia early in life impairs visual recognition memory

Repeated exposure to a common anesthesia drug early in life results in visual recognition memory impairment, which emerges after the first year of life and may persist long-term, according to a study from the Icahn School of Medicine at Mount Sinai and published online May 31 in the British Journal of Anaesthesia.

31 May 2017

Brain's immune cells may play roles in neurodegenerative, psychiatric illnesses

Scientists have, for the first time, characterized the molecular markers that make the brain's front lines of immune defense--cells called microglia--unique.

31 May 2017

Collaborative effort to develop rare disease patient registries

The Orphan Disease Center in the Perelman School of Medicine at the University of Pennsylvania will collaborate with Pulse Infoframe Inc., a medical informatics company, to develop rare disease patient registries aimed at enabling international collaboration to better understand these diseases, as well as accelerate and improve clinical studies to develop new therapies.

31 May 2017

Therapeutic small molecules safely prevent blood clots without excessive bleeding

It may be possible to disrupt harmful blood clots in people at risk for heart attack or stroke without increasing their risk of bleeding, according to a new study published in Nature Communications.

31 May 2017

Short-term functional high-intensity training may improve beta-cell function in adults with type 2 diabetes

A new study finds that short, functional-movement and resistance training workouts, called functional high-intensity training (F-HIT), may improve beta-cell function in adults with type 2 diabetes.

31 May 2017

MGH scientists show how Shigella survives journey from mouth to the colon

Surviving the treacherous journey through the human body from the mouth to the colon takes a special kind of bacterial pathogen.

31 May 2017

Brain changes after stroke may lead to increased preference for alcohol, research suggests

Brain changes after stroke may lead to increase in alcohol-seeking behavior, at least in animal models, according to research published Wednesday in the journal Scientific Reports.

31 May 2017

Clinical trial uses small molecule to treat men with incurable prostate cancer

NewYork-Presbyterian and Weill Cornell Medicine have begun the first clinical trial in the United States that uses a small molecule to treat men with progressive prostate cancer that has spread beyond the prostate and is no longer responding to hormonal therapy.

31 May 2017

TB germs' metabolic 'escape pathways' may be neutralized by new drugs to shorten duration of therapy

New research suggests the bacteria that cause tuberculosis alter their metabolism to combat exposure to antimicrobials, and that these metabolic "escape pathways" might be neutralized by new drugs to shorten the troublesome duration of therapy.

31 May 2017

Dutch scientists design self-destroying nanomotors to deliver and release drugs

Autonomous targeting and release of drugs at their site of action are desired features of nanomedical systems. Now, a team of Dutch scientists has designed a nanomotor that has these functions: An antitumor drug encapsulated in self-propelled, self-assembled stomatocytes is carried across the cellular membrane and released inside the cell upon a chemical redox signal that disassembles the vesicle membrane.

31 May 2017

Jaw malformations in zebrafish could provide clues about hearing loss in mice and humans

Can a fish with a malformed jaw tell us something about hearing loss in mice and humans? The answer is yes, according to a new publication in Scientific Reports.

31 May 2017

Medical Science News

Key metabolic enzyme fuels molecular machinery to turn on memory genes after learning

Study reveals key role of gut microbiota in treatment with classic diabetes medication

Researchers uncover new way to enhance function of immune cells to combat multiple myeloma

Cholesterol shown to have clear effect on lung surface properties

Researchers gain new insights into factors crucial for STIM1 activation

Scientists identify 100 genes that provide new entry points into understanding human memory

New method combines organoid technology with bioengineering to build better brains

Single protein allows mycobacteria to generate diverse populations and avoid TB drugs, research shows

Researchers discover molecular signaling circuit that regulates autophagy

Repeated exposure to anesthesia early in life impairs visual recognition memory

Brain's immune cells may play roles in neurodegenerative, psychiatric illnesses

Collaborative effort to develop rare disease patient registries

Therapeutic small molecules safely prevent blood clots without excessive bleeding

Short-term functional high-intensity training may improve beta-cell function in adults with type 2 diabetes

MGH scientists show how Shigella survives journey from mouth to the colon

Brain changes after stroke may lead to increased preference for alcohol, research suggests

Clinical trial uses small molecule to treat men with incurable prostate cancer

TB germs' metabolic 'escape pathways' may be neutralized by new drugs to shorten duration of therapy

Dutch scientists design self-destroying nanomotors to deliver and release drugs

Jaw malformations in zebrafish could provide clues about hearing loss in mice and humans

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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