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Researchers reveal potent new mechanism of action for treatment of IBD

Professor Akiyoshi Fukamizu's research group of Life Science Center for Survival Dynamics, University of Tsukuba, Eisai Co., Ltd. and its gastrointestinal business subsidiary EA Pharma Co., Ltd. have revealed a mechanism in which an analogue (ER-464195-01) of Eisai's in-house discovered E6007 inhibits integrin activation by dissociating interaction between calreticulin (CRT) and integrin α 4 (ITGA4), suppressing adhesion and infiltration of leukocytes overall.

25 May 2018

Research suggests link between faulty gene, alcohol, and heart failure

The researchers investigated faulty versions of a gene called titin which are carried by one in 100 people or 600,000 people in the UK.

25 May 2018

New findings could help fine-tune treatment for cancer patients

Cancer therapies that cut off blood supply to a tumor could be more effective in combination with existing chemotherapeutic drugs - according to new research from the University of East Anglia.

25 May 2018

Researchers identify neurons that play key role in aggressive behavior

High activity in a relatively poorly studied group of brain cells can be linked to aggressive behaviour in mice, a new study from Karolinska Institutet in Sweden shows.

25 May 2018

Researchers identify novel epigenetic mutations as cause of neurodevelopmental, congenital disorders

Researchers have identified a type of genetic aberration to be the cause of certain neurodevelopmental disorders and congenital diseases, such as autism and congenital heart disease, which are undetectable by conventional genetic testing.

25 May 2018

Cancer cells co-opt pain-sensing 'neural channel' to increase tolerance against oxidative stress

Anyone who's taken a bite of a sandwich with too much spicy mustard or a piece of sushi with too much wasabi can attest to the tear-inducing sensation these condiments can cause. These loud warnings to the nervous system of exposure to potentially harmful chemicals are triggered by TRPA1, a calcium channel protein sometimes referred to as the "wasabi receptor."

25 May 2018

New approach to study brown fat could aid in finding treatments for obesity

A new technique to study fat stores in the body could aid efforts to find treatments to tackle obesity.

25 May 2018

Study reveals new protective mechanism for tumor cells in breast cancer

Greater knowledge of the mechanisms that contribute to the survival of tumor cells is key to vanquishing them.

25 May 2018

Immune cells promote lung cancer metastases by forming clots in tumors, study finds

University of North Carolina Lineberger Comprehensive Cancer Center researchers have found that by helping to form clots within tumors, immune cells that flock to a particular type of lung cancer are actually building a foundation for the tumor to spread within the body.

25 May 2018

Origami inspires researchers to develop new solution for tissue regeneration

Origami - the Japanese art of folding paper into shapes and figures - dates back to the sixth century. At UMass Lowell, it is inspiring researchers as they develop a 21st-century solution to the shortage of tissue and organ donors.

25 May 2018

New drug-delivering nanoparticle could offer better way to treat brain tumors

Glioblastoma multiforme, a type of brain tumor, is one of the most difficult-to-treat cancers. Only a handful of drugs are approved to treat glioblastoma, and the median life expectancy for patients diagnosed with the disease is less than 15 months.

25 May 2018

Study links 'sleep spindles' to memory reactivation

Leading theories propose that sleep presents an opportune time for important, new memories to become stabilized. And it's long been known which brain waves are produced during sleep. But in a new study, researchers set out to better understand the brain mechanisms that secure memory storage.

24 May 2018

Researchers discover cascade of immune processes linked to poor outcomes in aggressive breast cancer

Cancer is crafty. To survive and thrive, tumors find a way of thwarting our body's natural systems.

24 May 2018

$2.3 million NIH grant to support new project on oxytocin neurons and social behavior

A team of Penn State researchers is planning to create a new map of the brain that will establish a neural circuit diagram of oxytocin, a compound often associated with affection and emotional behavior. Researchers hope the map will give them insight into how oxytocin in the brain drives social behavior.

24 May 2018

Two genes play vital roles in malignant brain cancer

Two genes play important roles for the formation of malignant cancer in the brain. One gene prevents the formation of the tumor, while another gene promotes the tumor. This is shown in a new dissertation at Umeå University, Sweden.

24 May 2018

Study defines molecular basis to explain connection between mother’s nutrition and infant growth

For years, pregnant mothers have questioned their nutritional habits: "Will eating more cause my baby to be overweight?" Or, "I'm eating for two, so it won't hurt to have an extra serving, right?"

24 May 2018

Researchers reveal stimulatory effects of myelin on young neural cells

Recovery after severe spinal cord injury is notoriously fraught, with permanent paralysis often the result. In recent years, researchers have increasingly turned to stem cell-based therapies as a potential method for repairing and replacing damaged nerve cells.

24 May 2018

Medical Science News

Researchers reveal potent new mechanism of action for treatment of IBD

Research suggests link between faulty gene, alcohol, and heart failure

New findings could help fine-tune treatment for cancer patients

Researchers identify neurons that play key role in aggressive behavior

Researchers identify novel epigenetic mutations as cause of neurodevelopmental, congenital disorders

Cancer cells co-opt pain-sensing 'neural channel' to increase tolerance against oxidative stress

New approach to study brown fat could aid in finding treatments for obesity

Study reveals new protective mechanism for tumor cells in breast cancer

Immune cells promote lung cancer metastases by forming clots in tumors, study finds

Origami inspires researchers to develop new solution for tissue regeneration

New drug-delivering nanoparticle could offer better way to treat brain tumors

Study links 'sleep spindles' to memory reactivation

Researchers discover cascade of immune processes linked to poor outcomes in aggressive breast cancer

$2.3 million NIH grant to support new project on oxytocin neurons and social behavior

Two genes play vital roles in malignant brain cancer

Study defines molecular basis to explain connection between mother’s nutrition and infant growth

Researchers reveal stimulatory effects of myelin on young neural cells

International researchers succeed in stopping growth of mesothelioma in model animals

Psychologists show that depression accelerates brain aging

New research reveals links between type 1 diabetes and mental health

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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