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Researchers show how changes along lining of mammary ducts can lead to breast cancer

Breast cancer researchers have mapped early genetic alterations in normal-looking cells at various distances from primary tumors to show how changes along the lining of mammary ducts can lead to disease.

1 Nov 2017

PARP inhibitors may have efficacy in selected TNBC patients outside of germline BRCA mutation

The investigational PARP inhibitor talazoparib caused regression of patient-derived xenografts (PDXs) of triple-negative breast cancers (TNBC) that had BRCA mutations and also those that did not have BRCA mutations but had other alterations in DNA damage-repair pathways.

1 Nov 2017

Starving childhood brain tumor of amino acid could improve effect of chemotherapy, study shows

Starving a childhood brain tumor of the amino acid glutamine could improve the effect of chemotherapy, according to an early study led by Queen Mary University of London and funded by Children with Cancer UK and the Medical Research Council.

1 Nov 2017

Gut bacteria composition could predict toxicity of chemotherapy drugs in cancer patients

Albert Einstein College of Medicine researchers report that the composition of people's gut bacteria may explain why some of them suffer life-threatening reactions after taking a key drug for treating metastatic colorectal cancer.

1 Nov 2017

Shear shock waves may explain why some head knocks cause more harm than others

Veteran sailors know that rogue waves can rise suddenly in mid-ocean to capsize even the largest vessels. Now it appears that a similar phenomenon called shear shock wave occurs in the concussed brain. It may help explain why some head knocks cause so much more harm than others.

1 Nov 2017

Scientists make breakthrough by suppressing aflatoxin-producing fungus in groundnut

Scientists at the Donald Danforth Plant Science Center, in St. Louis, MO and their collaborators at the International Crops Research Institute for the Semi-Arid Tropics in Hyderabad, India, United States Department of Agriculture and Louisiana State University have made a significant research breakthrough by suppressing the aflatoxin-producing fungus in groundnut.

1 Nov 2017

Research sheds light on how bones affect appetite and metabolism

Your skeleton is much more than the structure supporting your muscles and other tissues. It produces hormones, too. And Mathieu Ferron knows a lot about it.

1 Nov 2017

Tiny microscopes give researchers a peek into neural circuitry of social behavior

Tiny microscopes mounted on mice's heads have given researchers a peek into the neural circuitry of social behavior.

1 Nov 2017

Non-invasive diagnostic tool developed for early detection of ovarian cancer

Investigators from Brigham and Women's Hospital and Dana-Farber Cancer Institute are leveraging the power of artificial intelligence to develop a new technique to detect ovarian cancer early and accurately.

31 Oct 2017

Study findings may provide insight into excessive light sensitivity experienced by some people

The eyes are for seeing, but they have other important biological functions, including automatic visual reflexes that go on without awareness. The reflexive system of the human eye also produces a conscious, visual experience, according to a new study from researchers in the Perelman School of Medicine and School of Arts and Sciences at the University of Pennsylvania.

31 Oct 2017

Cleveland Clinic researchers win grants to study ethical issues involving brain surgery

The NIH BRAIN Initiative has awarded two Cleveland Clinic researchers grants to study ethical issues involving brain surgery, as part of the first neuroethics grants awarded by the initiative.

31 Oct 2017

Our chromosomes also wrinkle with age, research shows

Grey hair, wisdom, and wrinkles on our skin mark us as we age, but it's the more subtle changes beneath the surface that make us old. Now, researchers have discovered that our chromosomes also wrinkle with age, changing how our immune system renews itself.

31 Oct 2017

Study shows effects of prenatal BPA exposure at low levels in developing rodent brain

New research from North Carolina State University reveals that prenatal exposure to bisphenol A (BPA) at levels below those currently considered safe for humans affects gene expression related to sexual differentiation and neurodevelopment in the developing rat brain.

31 Oct 2017

Study links signs of heightened arousal in PTSD to overactivity of locus coeruleus

A new study in Biological Psychiatry has linked signs of heightened arousal and reactivity -- a core symptom of posttraumatic stress disorder (PTSD) -- to overactivity of the locus coeruleus (LC), a brain region that mediates arousal and reactivity. By combining bodily responses and brain imaging data, the new paper by Dr. Christoph Mueller-Pfeiffer at the University of Zurich, Switzerland and colleagues is the first to provide direct human evidence for a theory over 30 years old.

31 Oct 2017

Findings offer new approach for detecting dyslexia risk before children learn to read

Almost 10% of the world population suffers dyslexia. Establishing an early diagnosis would allow the development of training programs to palliate this disorder.

31 Oct 2017

Stem cells do not participate directly in cartilage regeneration but serve to ‘animate’ the process

Stem cell therapy has great potential for curing cartilage damage. However, it has remained unclear whether stem cells are responsible for regeneration or whether they trigger the process.

31 Oct 2017

Gene therapy prevents age-related learning and memory problems in mice

Researchers from the Institute of Neurosciences at the Universitat Autònoma de Barcelona and the Vall d'Hebron Research Institute are the first to demonstrate that regulation of the brain's Klotho gene using gene therapy protects against age-related learning and memory problems in mice.

31 Oct 2017

Alzheimer's disease could be triggered by breakdowns from other parts of the body

Alzheimer's disease, the leading cause of dementia, has long been assumed to originate in the brain. But research from the University of British Columbia and Chinese scientists indicates that it could be triggered by breakdowns elsewhere in the body.

31 Oct 2017

New biomarkers could help doctors diagnose traumatic brain injury through simple blood test

UCLA researchers have identified four biomarkers that could help doctors diagnose brain trauma and concussions through a simple blood test. The biomarkers are proteins, from brain cells called astrocytes, which are released instantly into the bloodstream when astrocytes' outer membranes rupture from blunt impact or whiplash trauma.

31 Oct 2017

Researchers identify link between circadian rhythm disturbance and brain dysfunction

Researchers at Okayama University describe in the Journal of Neuroscience that a certain protein known to play a major role in circadian rhythmicity — humans’ intrinsic 24-hour biological cycle — is also key to proper brain functioning.

31 Oct 2017

Medical Science News

Researchers show how changes along lining of mammary ducts can lead to breast cancer

PARP inhibitors may have efficacy in selected TNBC patients outside of germline BRCA mutation

Starving childhood brain tumor of amino acid could improve effect of chemotherapy, study shows

Gut bacteria composition could predict toxicity of chemotherapy drugs in cancer patients

Shear shock waves may explain why some head knocks cause more harm than others

Scientists make breakthrough by suppressing aflatoxin-producing fungus in groundnut

Research sheds light on how bones affect appetite and metabolism

Tiny microscopes give researchers a peek into neural circuitry of social behavior

Non-invasive diagnostic tool developed for early detection of ovarian cancer

Study findings may provide insight into excessive light sensitivity experienced by some people

Cleveland Clinic researchers win grants to study ethical issues involving brain surgery

Our chromosomes also wrinkle with age, research shows

Study shows effects of prenatal BPA exposure at low levels in developing rodent brain

Study links signs of heightened arousal in PTSD to overactivity of locus coeruleus

Findings offer new approach for detecting dyslexia risk before children learn to read

Stem cells do not participate directly in cartilage regeneration but serve to ‘animate’ the process

Gene therapy prevents age-related learning and memory problems in mice

Alzheimer's disease could be triggered by breakdowns from other parts of the body

New biomarkers could help doctors diagnose traumatic brain injury through simple blood test

Researchers identify link between circadian rhythm disturbance and brain dysfunction

Fourier 80: bringing benchtop NMR systems to the laboratory

How industrial hygiene flow calibration supports defensible exposure data

How electrical engineering ensures accurate calibration and patient safety

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