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Potential new class of drugs lessen neurodegeneration in rat model of Parkinson's disease

The first test in a mammalian model of a potential new class of drugs to treat Parkinson's disease shows abatement of neurodegeneration in the brains of test rats and no significant toxicities, University of Alabama at Birmingham and Pfizer Inc. researchers report online in The Journal of Biological Chemistry.

26 Jun 2015

Lamont R Jones receives 2015 Research Scholar Award to study pathogenesis of keloids

Lamont R Jones, M.D., vice chair of the Department of Otolaryngology-Head & Neck Surgery at Henry Ford Hospital, received the 2015 Research Scholar Award from the Educational and Research Foundation for the American Academy of Facial Plastic and Reconstructive Surgery to continue his efforts to study the pathogenesis of keloids and improve understanding of how keloid scars develop.

26 Jun 2015

Study reveals differences in the way brain inflammation is expressed in people with Down syndrome, AD

Researchers at the University of Kentucky's Sanders-Brown Center on Aging have completed a study that revealed differences in the way brain inflammation -- considered a key component of AD-- is expressed in different subsets of patients, in particular people with Down syndrome (DS) and AD.

26 Jun 2015

Study may help find strategies to control mosquito populations

Every time you put on bug spray this summer, you're launching a strike in the ongoing war between humans and mosquitoes -- one that is rapidly driving the evolution of the pests. Scientists studying mosquitoes in various types of environments in the United States and in Russia found that between 5 and 20 percent of a mosquito population's genome is subject to evolutionary pressures at any given time -- creating a strong signature of local adaptation to environment and humans.

26 Jun 2015

UC Santa Barbara professor develops novel therapeutic strategy for PKD

For the 12 million people worldwide who suffer from polycystic kidney disease (PKD), an inherited disorder with no known cure, a new treatment option may be on the horizon.

26 Jun 2015

Caltech chemists develop new sensitive technique that can detect colorectal cancer in tissue samples

Chemists at Caltech have developed a new sensitive technique capable of detecting colorectal cancer in tissue samples -- a method that could one day be used in clinical settings for the early diagnosis of colorectal cancer.

26 Jun 2015

New Internet tool may help analyze genes based on their evolutionary profile

Two major revolutions, one genomic and one in informatics, are completely changing the face of biomedical research. Every day all over the world, millions of genetic sequences -- from disease-related genes to complete genomes of plants, animals, bacteria and viruses -- are resolved, identified and dissected.

26 Jun 2015

UAlberta scientists explore physical principles underlying formation of misfolded protein aggregates

Working towards the ultimate goal to develop therapeutics to treat diseases such as Alzheimer's, Parkinson's, ALS, and BSE (Mad Cow Disease), University of Alberta scientists Michael Woodside, Hao Yu, and Derek Dee are investigating the physical principles underlying the formation of misfolded protein aggregates.

26 Jun 2015

Growth of lymph node metastases takes advantage of existing blood vessels

While the use of antiangiogenesis drugs that block the growth of new blood vessels can improve the treatment of some cancers, clinical trials of their ability to prevent the development of new metastases have failed. Now a study from the Massachusetts General Hospital Cancer Center may have found at least one reason why.

26 Jun 2015

Malaria parasite protein essential for parasite invasion into red blood cells

A new study led by researchers at Harvard T.H. Chan School of Public Health finds that a malaria parasite protein called calcineurin is essential for parasite invasion into red blood cells. Human calcineurin is already a proven target for drugs treating other illnesses including adult rheumatoid arthritis and lupus, and the new findings suggest that parasite calcineurin should be a focus for the development of new antimalarial drugs.

26 Jun 2015

IU researchers find that microRNA-29 may be potent therapeutic target against pancreatic cancer

Indiana University cancer researchers found that a particular microRNA may be a potent therapeutic agent against pancreatic cancer. The research was published June 22 in the journal Scientific Reports.

26 Jun 2015

Scientists develop small molecule drug that prevents autophagy from starting in cancer cells

As a tumor grows, its cancerous cells ramp up an energy-harvesting process to support its hasty development. This process, called autophagy, is normally used by a cell to recycle damaged organelles and proteins, but is also co-opted by cancer cells to meet their increased energy and metabolic demands.

26 Jun 2015

Animal study highlights major safety concern regarding use of MRI contrast agents in patients

New results in animals highlight a major safety concern regarding a class of magnetic resonance imaging (MRI) contrast agents used in millions of patients each year, according to a paper published online by the journal Investigative Radiology.

26 Jun 2015

New chemical compound reduces pancreatic cancer tumour growth by 80% in mice

Scientists from UCL (University College London) have designed a chemical compound that has reduced the growth of pancreatic cancer tumours by 80 percent in treated mice.

26 Jun 2015

Lund University research questions the doctrine on how the brain recognizes and processes information

New research from Lund University in Sweden questions the prevailing doctrine on how the brain absorbs and processes information. The idea that the brain has a mechanism to maintain activity at the lowest possible level is incorrect.

26 Jun 2015

Fructose stimulates reward system in the brain to a lesser degree than glucose

Fructose not only results in a lower level of satiety, it also stimulates the reward system in the brain to a lesser degree than glucose. This may cause excessive consumption accompanied by effects that are a risk to health, report researchers from the University of Basel in a study published in the scientific journal PLOS ONE. Various diseases have been attributed to industrial fructose in sugary drinks and ready meals.

26 Jun 2015

Experimental new treatment approach can send deadly leukemia into remission

An experimental new treatment approach for a rare, deadly leukemia can send the disease into remission even in patients for whom the standard therapy has failed, buying them more time to have the stem cell transplant that could save their lives, a small pilot study has found.

26 Jun 2015

University of Pittsburgh surgeon receives Anthony Cerami Award in Translational Medicine

The Feinstein Institute for Medical Research and Molecular Medicine announced today that the fourth Anthony Cerami Award in Translational Medicine will be conferred to Thomas E. Starzl, MD, PhD, professor of surgery at the University of Pittsburgh School of Medicine. The award is in recognition of his research in organ transplantation and alloengraftment mechanisms.

26 Jun 2015

Alabama scientists show how phytochemical in magnolia works against head and neck cancers

Magnolias are prized for their large, colorful, fragrant flowers. Does the attractive, showy tree also harbor a potent cancer fighter?

26 Jun 2015

E2F4 biomarker can help predict prognosis and response to BCG therapy in bladder cancer

Investigators from Dartmouth's Norris Cotton Cancer Center harnessed genomic data to discover that the previously identified E2F4 signature in breast cancer can be utilized to predict prognosis and response to therapy in bladder cancer.

25 Jun 2015

Medical Science News

Potential new class of drugs lessen neurodegeneration in rat model of Parkinson's disease

Lamont R Jones receives 2015 Research Scholar Award to study pathogenesis of keloids

Study reveals differences in the way brain inflammation is expressed in people with Down syndrome, AD

Study may help find strategies to control mosquito populations

UC Santa Barbara professor develops novel therapeutic strategy for PKD

Caltech chemists develop new sensitive technique that can detect colorectal cancer in tissue samples

New Internet tool may help analyze genes based on their evolutionary profile

UAlberta scientists explore physical principles underlying formation of misfolded protein aggregates

Growth of lymph node metastases takes advantage of existing blood vessels

Malaria parasite protein essential for parasite invasion into red blood cells

IU researchers find that microRNA-29 may be potent therapeutic target against pancreatic cancer

Scientists develop small molecule drug that prevents autophagy from starting in cancer cells

Animal study highlights major safety concern regarding use of MRI contrast agents in patients

New chemical compound reduces pancreatic cancer tumour growth by 80% in mice

Lund University research questions the doctrine on how the brain recognizes and processes information

Fructose stimulates reward system in the brain to a lesser degree than glucose

Experimental new treatment approach can send deadly leukemia into remission

University of Pittsburgh surgeon receives Anthony Cerami Award in Translational Medicine

Alabama scientists show how phytochemical in magnolia works against head and neck cancers

E2F4 biomarker can help predict prognosis and response to BCG therapy in bladder cancer

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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