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Researchers identify mechanisms behind loss of sensory perception in Parkinson's disease

Although Parkinson's disease is often associated with motor symptoms such as stiffness, poor balance and trembling, the first symptoms are often sensory and include a reduced sense of touch and smell. In a study on mice, researchers at Karolinska Institutet have now been able to identify neural circuits and mechanisms behind this loss of sensory perception.

18 May 2017

Sperm epigenetics and fertility

Epigenetics is a system of information that lies atop DNA to control which genes are accessible, active and inactive. Each cell in your body essentially has identical DNA, but they have different patterns of expression.

18 May 2017

Tumor mutation load in patient's biopsy varies by age and type of cancer

A team of investigators led by researchers at Georgetown Lombardi Comprehensive Cancer Center has found that the tumor mutation load, or TML, in a patient's cancer biopsy varied by age and the type of cancer, along with several other factors.

18 May 2017

Researchers identify DNA repair deficiency in many types of solid tumors

A new investigation of more than 48,000 stored tumor samples finds evidence of a key deficiency in a repair mechanism designed to keep DNA from being mutated and causing cancer.

18 May 2017

Newly identified biomarkers could help predict cognitive deficits in Parkinson's disease patients

New biomarkers identified by a research team in the Perelman School of Medicine at the University of Pennsylvania could help predict which Parkinson's disease patients will suffer significant cognitive deficits within the first three years of their diagnosis.

18 May 2017

Brisbane researchers synthetically re-create Zika virus to better understand birth defects

Brisbane researchers have synthetically re-created Zika virus in the laboratory - a breakthrough which will help to understand the virus and the fetal brain defects it causes.

17 May 2017

$Innovative technique could replace bone grafts to repair severe limb fractures$

Innovative technique could replace bone grafts to repair severe limb fractures

A Cedars-Sinai-led team of investigators has successfully repaired severe limb fractures in laboratory animals with an innovative technique that cues bone to regrow its own tissue.

17 May 2017

Microbes can manipulate molecular machinery of host cells to influence health

All animals -- from sea sponges to modern-day humans -- evolved in a world already teeming with microbes. These single-celled microorganisms now cover practically every surface of our bodies and are as much a part of our biology as our own tissues and organs.

17 May 2017

Researchers identify new drug target for two common types of myeloid leukemia

University of Georgia researchers, with colleagues from the University of Tokyo, have identified a new drug target for the two most common types of myeloid leukemia, including a way to turn back the most aggressive form of the disease.

17 May 2017

Researchers identify new way to prevent pneumococci from entering the brain

An international team of researchers, led from Karolinska Institutet, has identified two receptors on the cells in the blood vessels of the brain that can be blocked and thereby prevent pneumococci from entering the brain.

17 May 2017

Researchers develop new strategy that can revolutionize HIV vaccine design

Vaccines are an essential tool for preventing and treating serious infectious diseases such as polio, chicken pox and measles. But so far it has not been possible to develop vaccines capable of contributing to the treatment and prevention of chronic infectious diseases such as HIV and hepatitis C.

17 May 2017

Scientists identify gene linked to incurable bowel disorders

A key gene that helps to explain an underlying cause of incurable bowel disorders such as Crohn's disease has been identified by scientists.

17 May 2017

Research identifies 'cell messages' that could help detect early stages of osteoarthritis

New research from the University of Liverpool, published today in the journal 'NPJ Systems Biology and Applications', has identified 'cell messages' that could help identify the early stages of osteoarthritis.

17 May 2017

Study measures increased 'fight or flight' response in young veterans with combat-related PTSD

A new study published this week in the Journal of Physiology finds that young veterans with combat-related post-traumatic stress disorder (PTSD) have an increased 'fight or flight' response during mental stress.

17 May 2017

History of sleep: what was normal?

We used to sleep in two phases, with a first sleep and then a second sleep. Arguably from time immemorial to the nineteenth century, the dominant pattern of sleep in Western societies was biphasic, whereby most preindustrial households retired between 9 and 10pm, slept for 3 to 3 ½ hours during their “first sleep,”

17 May 2017

Researchers identify key inflammatory cells involved in nonalcoholic fatty liver disease

A team of investigators led by Rohit Kohli, MBBS, MS, of Children's Hospital Los Angeles, has identified key inflammatory cells involved in nonalcoholic fatty liver disease.

17 May 2017

Small molecules in saliva show potential for early diagnosis of Alzheimer's disease

Your spit may hold a clue to future brain health. Investigators at the Beaumont Research Institute, part of Beaumont Health in Michigan, are hopeful that their study involving small molecules in saliva will help identify those at risk of developing Alzheimer's disease - a neurologic condition predicted to reach epidemic proportions worldwide by 2050.

17 May 2017

Children surviving chronic health conditions may suffer from brain function issues

Survival rates continue to rise for children living with once-fatal chronic pediatric health conditions. But their survival comes at a cost: many experience long-term neurocognitive deficits.

17 May 2017

‘Disease in a dish’ model pinpoints how defects in blood-brain barrier can cause psychomotor disorder

Scientists for the first time have assembled a "disease in a dish" model that pinpoints how a defect in the blood-brain barrier can produce an incurable psychomotor disorder, Allan-Herndon-Dudley syndrome.

17 May 2017

Neurobiologists uncover reason for defects in the blood-brain barrier of Huntington's disease patients

By using induced pluripotent stem cells to create endothelial cells that line blood vessels in the brain for the first time for a neurodegenerative disease, University of California, Irvine neurobiologists and colleagues have learned why Huntington's disease patients have defects in the blood-brain barrier that contribute to the symptoms of this fatal disorder.

17 May 2017

Medical Science News

Researchers identify mechanisms behind loss of sensory perception in Parkinson's disease

Sperm epigenetics and fertility

Tumor mutation load in patient's biopsy varies by age and type of cancer

Researchers identify DNA repair deficiency in many types of solid tumors

Newly identified biomarkers could help predict cognitive deficits in Parkinson's disease patients

Brisbane researchers synthetically re-create Zika virus to better understand birth defects

Innovative technique could replace bone grafts to repair severe limb fractures

Microbes can manipulate molecular machinery of host cells to influence health

Researchers identify new drug target for two common types of myeloid leukemia

Researchers identify new way to prevent pneumococci from entering the brain

Researchers develop new strategy that can revolutionize HIV vaccine design

Scientists identify gene linked to incurable bowel disorders

Research identifies 'cell messages' that could help detect early stages of osteoarthritis

Study measures increased 'fight or flight' response in young veterans with combat-related PTSD

History of sleep: what was normal?

Researchers identify key inflammatory cells involved in nonalcoholic fatty liver disease

Small molecules in saliva show potential for early diagnosis of Alzheimer's disease

Children surviving chronic health conditions may suffer from brain function issues

‘Disease in a dish’ model pinpoints how defects in blood-brain barrier can cause psychomotor disorder

Neurobiologists uncover reason for defects in the blood-brain barrier of Huntington's disease patients

Fourier 80: bringing benchtop NMR systems to the laboratory

How industrial hygiene flow calibration supports defensible exposure data

How electrical engineering ensures accurate calibration and patient safety

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