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Lower quantities of CD74 protein in placentas of preeclamptic women can impact fetal development

Preeclampsia is one of the most common complications to occur during pregnancy, yet its causes are still unknown. A new study involving patients, cell cultures and animal experiments has now shown that those affected by the disease have lower quantities of the placenta's immune protein CD74, and that certain inflammatory factors are higher. These factors disrupt the formation of the placenta and leave the fetus undernourished.

3 Jun 2016

Researchers explore how ALS develops from muscle perspective

In an effort to better understand what happens during Amyotrophic Lateral Sclerosis (ALS), researchers at Umea University in Sweden have compared the impact of ALS on the eye and limb muscles.

3 Jun 2016

Accumulation of fat droplets makes cancer cells more aggressive

It has been established that not all cancer cells are equally aggressive - most can be neutralised with radiation and chemotherapy. Researchers at Lund University in Sweden have now discovered that some cancer cells can accumulate fat droplets, which appear to make them more aggressive and increase their ability to spread.

3 Jun 2016

Mayo study finds mechanism by which Pten safeguards against tumor formation

Pten (short for phosphatase and tensin homolog) is a tumor suppressor that is defective in about 20-25 percent of all patients with cancers. Mayo Clinic researchers now have discovered that Pten safeguards against tumor formation by keeping chromosome numbers intact when a cell splits into two daughter cells.

3 Jun 2016

DRD2 expression plays crucial role in protecting mice against kidney injury, hypertension

Dopamine signaling in the kidneys plays a critical role in blood pressure regulation and is responsible for nearly half of the salt and water excretion that occurs in response to increased dietary salt intake. Notably, genetic deletion of any of the 5 dopamine receptors expressed in the kidney causes hypertension in mice.

3 Jun 2016

Researchers detect vascular matrix stiffening during early stages of pulmonary hypertension

Pulmonary hypertension is an abnormal elevation of pressure in the pulmonary circulation that results in stress on the heart and remodeling of blood vessels in the lung.

3 Jun 2016

Tecan releases updated software package for D300e Digital Dispenser

Tecan is making it easier than ever before to set up and miniaturize qPCR reactions. In direct response to customer requests, the company has launched an updated software package for its D300e Digital Dispenser, offering new functionality and extending this innovative device’s flexibility for genomics workflows.

From Tecan 3 Jun 2016

Scientists use new technique to repair fibrotic liver cells within the organ

Advances in stem cell research have made it possible to convert patients' skin cells into heart cells, kidney cells, liver cells and more in the lab dish, giving researchers hope that one day such cells could replace organ transplantation for patients with organ failure.

3 Jun 2016

Stimulating STING pathway to provoke life-extending immune response shows promise in AML

A protein known as STING plays a crucial role in the immune system's ability to "sense" cancer by recognizing and responding to DNA from tumor cells. Injection of compounds that activate the STING pathway directly into solid tumors in mice has been shown in prior studies to result in very potent anti-tumor immune responses.

3 Jun 2016

Fasnall drug appears to inhibit tumor growth by promoting cancer cell death

A promising new compound appears to impede a process that fuels breast cancer in mice, a discovery that could have implications in the treatment of a host of cancers.

3 Jun 2016

Scientists discover master dimmer switches that control activity of immune cells

A person's genetic makeup plays a role in autoimmune diseases such as multiple sclerosis that develop when the body is attacked by its own immune system. But little is known about how immune cells are pushed into overdrive.

3 Jun 2016

NMNAT2 enzyme may help protect against debilitating effects of neurodegenerative disorders

A study led by biomedical researchers at Indiana University has found evidence that an enzyme known as NMNAT2 may help protect against the debilitating effects of certain degenerative brain diseases, including Alzheimer's.

3 Jun 2016

Analysing blood metabolites may help monitor effects of novel drugs

Testing for metabolic changes in the blood could indicate whether a cancer drug is working as designed, a new study reports.

3 Jun 2016

New mouse model allows researchers to evaluate CD40-antibody drugs effectively

Cancer immunotherapies--drugs that work by making a patient's immune system better at spotting and destroying tumor cells--are increasingly generating headlines. A number of these drugs are now being used for the treatment of melanoma, lung, and kidney cancers, and are showing promise in clinical trials with other diseases as well.

3 Jun 2016

Fluctuations in tRNA may play vital role in cancer metastasis

At any given moment, the human genome spells out thousands of genetic words telling our cells which proteins to make. Each word is read by a molecule known as a tRNA.

3 Jun 2016

Scientists identify cellular mechanisms of altered skin wound repair in elderly patients

Each injury means a little more as individuals age -- more impact and more healing time.

3 Jun 2016

Study reinforces significance of raising young children in stimulating environments

A recent study shows that infants and toddlers take longer to notice new visual stimuli and are less accurate in their gaze than adults, but slowly improve as they age. The findings reinforce the importance of raising young children in stimulating environments, and set an important baseline as detection of developmental disorders increasingly rely on tracking eye movements.

3 Jun 2016

Common genetic variant in HO-1 gene linked to AKI risk following cardiac surgery

Testing for a common genetic variant may help reveal which patients face an increased risk of developing kidney damage following heart surgery. The findings, which come from a study appearing in an upcoming issue of the Journal of the American Society of Nephrology, may help investigators develop therapeutic strategies to mitigate this damage.

3 Jun 2016

Lund researchers identify four genetic keys that can unlock code, reprogram skin cells

Eight days. That's how long it takes for skin cells to reprogram into red blood cells. Researchers at Lund University in Sweden, together with colleagues at Center of Regenerative Medicine in Barcelona, have successfully identified the four genetic keys that unlock the genetic code of skin cells and reprogram them to start producing red blood cells instead.

3 Jun 2016

Gut microbe's metabolite butyrate hampers intestinal repair from IBD

Intestinal stem cells are among the most rapidly dividing cells in the body, busily creating new cells to replace the ones that are constantly being sloughed off. But unlike stem cells elsewhere in the body, those in the intestine are hidden away, and for good reason, it turns out.

3 Jun 2016

Medical Science News

Lower quantities of CD74 protein in placentas of preeclamptic women can impact fetal development

Researchers explore how ALS develops from muscle perspective

Accumulation of fat droplets makes cancer cells more aggressive

Mayo study finds mechanism by which Pten safeguards against tumor formation

DRD2 expression plays crucial role in protecting mice against kidney injury, hypertension

Researchers detect vascular matrix stiffening during early stages of pulmonary hypertension

Tecan releases updated software package for D300e Digital Dispenser

Scientists use new technique to repair fibrotic liver cells within the organ

Stimulating STING pathway to provoke life-extending immune response shows promise in AML

Fasnall drug appears to inhibit tumor growth by promoting cancer cell death

Scientists discover master dimmer switches that control activity of immune cells

NMNAT2 enzyme may help protect against debilitating effects of neurodegenerative disorders

Analysing blood metabolites may help monitor effects of novel drugs

New mouse model allows researchers to evaluate CD40-antibody drugs effectively

Fluctuations in tRNA may play vital role in cancer metastasis

Scientists identify cellular mechanisms of altered skin wound repair in elderly patients

Study reinforces significance of raising young children in stimulating environments

Common genetic variant in HO-1 gene linked to AKI risk following cardiac surgery

Lund researchers identify four genetic keys that can unlock code, reprogram skin cells

Gut microbe's metabolite butyrate hampers intestinal repair from IBD

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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