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Enzyme protein neutrophil elastase may be key contributor to development of muscular dystrophy

Scientists at the University of Liverpool have discovered that muscle cells affected by muscular dystrophy contain high levels of an enzyme that impairs muscle repair. This finding provides a new target for potential drug treatments for the disease, which currently has no cure.

2 Jun 2016

Study reveals gpihbp1 gene could be novel target for treatment of muscular dystrophy

The average healthy man is 54 percent muscle by mass, but people with muscular dystrophy, an incurable, genetic condition, have almost no muscle at terminal stages of the disease.

2 Jun 2016

Prenatal mild viral assault may cause central nervous system malfunctions in children

Babies born to mothers whose immune systems had to grapple with a viral assault -- even a mild one -- have increased risk of brain and central nervous system abnormalities, according to a new study.

2 Jun 2016

Infection may trigger development of Alzheimer's disease

A growing body of research on Alzheimer's disease suggests an infectious trigger for the development of the disease. According to Brian Balin, PhD, professor of pathology and chair of bio-medical sciences at Philadelphia College of Osteopathic Medicine, this could be the key to stopping the destructive process of Alzheimer's before it even starts.

2 Jun 2016

Excess phosphates in foods may lead to abnormally high blood pressure

Excess consumption of phosphate over-activates nerves that raise blood pressure, leading to abnormally high blood pressure, a new study in the American Journal of Physiology—Regulatory, Integrative and Comparative Physiology reports.

2 Jun 2016

New IRAP inhibitors may hold promise for improving cognitive functions in animal models

Researchers have discovered three new inhibitors of insulin-regulated aminopeptidase (IRAP), compounds shown to improve cognitive functions in animal models of human disorders.

2 Jun 2016

Correcting defective p73 gene function may be promising therapeutic strategy for chronic lung diseases

Rising global air pollution and increasing smoking prevalence in many developing nations will likely lead to a growing incidence of lung diseases such as chronic obstructive pulmonary disease (COPD), which currently affects more than 330 million people worldwide, is the third-leading cause of death and carries an estimated healthcare cost of $2.1 trillion.

2 Jun 2016

Multiple cell and gene therapies can enhance cardiac function in mice modeled with MI

Researchers at the University of Utah compared the therapeutic potential of umbilical cord-derived sub-epithelial cells (UC-SECs), bone marrow-derived mesenchymal stem cells (BM-MSCs) and induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) -- all derived from human tissue -- along with genes (S100a1 and SDF-1a) and growth factor (VEGF165) to evaluate how injected biologics might enhance cardiac function in mice modeled with myocardial infarction (MI; commonly referred to as heart attack).

2 Jun 2016

$CD34+ cell therapy improves angina frequency in no option patients with class III/IV angina refractory$

CD34+ cell therapy improves angina frequency in no option patients with class III/IV angina refractory

A two-year, multi-center clinical study with 167 patients with class III-IV refractory angina randomized to low and high dose CD34+ cells or placebo has revealed that patients who received either a high or low dose of CD34 -- a member of a family of proteins that have an impact on vascular-associated tissue -- cells had a significant reduction in angina frequency over patients who received placebo.

2 Jun 2016

Experts urge cancer researchers to use old, obese mice for preclinical immunotherapy studies

Researchers should include laboratory mice that are old and obese in their studies of immunotherapy treatments for cancer, according to a review article by Saint Louis University scientists.

2 Jun 2016

Testing for maternal alcohol biomarkers in blood may help identify pregnancies at high FAS risk

It is well known that drinking during pregnancy can lead to fetal alcohol syndrome (FAS) in the offspring. Unfortunately, not all pregnant women are truthful about their levels of drinking.

2 Jun 2016

Buck researchers identify new, potential drug targets for sporadic PD

Research at the Buck Institute shows the same mechanisms that lead to neuronal cell death in mice genetically fated to develop Parkinson's disease (PD) are involved in the much more common sporadic form of the age-related, neurodegenerative disorder that robs people of the ability to move normally.

2 Jun 2016

Study shows women with migraine history have rapid decline in estrogen levels

Researchers have long known that sex hormones such as estrogen play a role in migraine. But there's been little research on how that works. Do women with migraine have higher estrogen levels in general? Higher levels at the peak of the monthly cycle?

2 Jun 2016

New drugs show promise as first antidote for radiation exposure

University of Virginia School of Medicine researchers have identified promising drugs that could lead to the first antidote for radiation exposure that might result from a dirty bomb terror attack or a nuclear accident such as Chernobyl.

2 Jun 2016

New research reveals functioning of brain's cleaning up mechanisms in neurodegenerative diseases

A piece of research led by the Achucarro Basque Center for Neuroscience, the University of the Basque Country, and the Ikerbasque Foundation has revealed how the brain's cleaning up mechanisms function in neurodegenerative diseases.

1 Jun 2016

New roadmap can help guide researchers to speed up biomarker-based research on Alzheimer's disease

Biomarkers could revolutionise the early detection of and therapy for Alzheimer's disease. However, experts attending the Congress of the European Academy of Neurology in Copenhagen criticized that the big breakthroughs are slow in coming because of a lack of priorities in research.

1 Jun 2016

Vocal learning in songbirds sheds more light on developmental disorders in humans

Adult songbirds modify their vocalizations when singing to juveniles in the same way that humans alter their speech when talking to babies. The resulting brain activity in young birds could shed light on speech learning and certain developmental disorders in humans, according to a study by McGill University researchers.

1 Jun 2016

Brain scan combined with long-term memory test could help early Alzheimer's diagnosis

People with Alzheimer's disease could benefit from earlier diagnosis if a long-term memory test combined with a brain scan were carried out, a study suggests.

1 Jun 2016

Mediodorsal thalamus plays key role in new learning and decision making

Scientists have confirmed one of the brain areas responsible for rapid updating of information during learning - the sort of information we use to negotiate many changing situations in everyday life.

1 Jun 2016

Toxic substance acrolein may play role in preventing fibrillation linked to Alzheimer's disease

Scientists from RIKEN in Japan have discovered that acrolein—a toxic substance produced in cells during times of oxidative stress—in fact may play a role in preventing the process of fibrillation, an abnormal clumping of peptides that has been associated with Alzheimer's disease and other neural diseases.

1 Jun 2016

Medical Science News

Enzyme protein neutrophil elastase may be key contributor to development of muscular dystrophy

Study reveals gpihbp1 gene could be novel target for treatment of muscular dystrophy

Prenatal mild viral assault may cause central nervous system malfunctions in children

Infection may trigger development of Alzheimer's disease

Excess phosphates in foods may lead to abnormally high blood pressure

New IRAP inhibitors may hold promise for improving cognitive functions in animal models

Correcting defective p73 gene function may be promising therapeutic strategy for chronic lung diseases

Multiple cell and gene therapies can enhance cardiac function in mice modeled with MI

CD34+ cell therapy improves angina frequency in no option patients with class III/IV angina refractory

Experts urge cancer researchers to use old, obese mice for preclinical immunotherapy studies

Testing for maternal alcohol biomarkers in blood may help identify pregnancies at high FAS risk

Buck researchers identify new, potential drug targets for sporadic PD

Study shows women with migraine history have rapid decline in estrogen levels

New drugs show promise as first antidote for radiation exposure

New research reveals functioning of brain's cleaning up mechanisms in neurodegenerative diseases

New roadmap can help guide researchers to speed up biomarker-based research on Alzheimer's disease

Vocal learning in songbirds sheds more light on developmental disorders in humans

Brain scan combined with long-term memory test could help early Alzheimer's diagnosis

Mediodorsal thalamus plays key role in new learning and decision making

Toxic substance acrolein may play role in preventing fibrillation linked to Alzheimer's disease

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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