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New EU project aims to develop models that can help predict behavior of cancer-related signaling pathways

A group of scientists at Helmholtz Zentrum München will engage in a new project promoted by the EU. The scientists in the team of Dr. Jan Hasenauer, head of the young investigator group 'Data-driven Computational Modeling' work as part of CanPathPro.

4 May 2016

Researchers identify 43 specific genes associated with both autism and cancer

Autism and cancer share more than 40 risk genes, suggesting that common mechanisms underlying the functions of some of these genes could conceivably be leveraged to develop therapies not just for cancer but for autism as well, an extensive assessment by researchers with the UC Davis MIND Institute and Comprehensive Cancer Center has found.

4 May 2016

Researchers develop molecule that binds to GAA enzymes key to progress of Pompe disease

Researchers at Leiden University have made a breakthrough in the study of the hereditary Pompe disease. Together with colleagues in York, they have developed a molecule that binds to the enzyme that is key to the progress of the disease. The findings have been published in ACS Central Science.

4 May 2016

Study shows syringe-like device acts as traffic cop directing bacteria to carry out infection

A study has found that a syringe-like device used to invade intestinal cells also acts as a traffic cop -- directing bacteria where to go and thereby enabling them to efficiently carry out infection.

4 May 2016

Riluzole drug can reverse key genetic changes linked to Alzheimer's disease

Aging takes its toll on the brain, and the cells of the hippocampus--a brain region with circuitry crucial to learning and memory--are particularly vulnerable to changes that can lead to Alzheimer's disease or cognitive decline. With the hope of counteracting the changes that can lead to these two conditions, researchers at Rockefeller University and their colleagues have begun examining the effects of a drug known to affect this circuitry.

4 May 2016

Lumbar drain placement lowers postoperative CSF leak rate for patients undergoing endoscopic endonasal surgery

Winner of the Synthes Skull Base Award, Nathan T. Zwagerman, MD, presented his research, A Prospective, Randomized Control Trial for Lumbar Drain Placement after Endoscopic Endonasal Skull Base Surgery, during the 2016 American Association of Neurological Surgeons Annual Scientific Meeting.

4 May 2016

Study finds link between placenta and offspring bone

Researchers at the Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, studied 518 children in the Avon Longitudinal Study of Parents and Children (ALSPAC) who underwent bone scans at nine, 15 and 17 years old. Measurements such as thickness, volume and weight, were also taken from the mothers' placenta.

4 May 2016

Biomedical researcher wins 2016 Gutenberg Research Award for work on programmed cell death

The Gutenberg Research College of Johannes Gutenberg University Mainz has chosen to give the 2016 Gutenberg Research Award to American biomedical researcher Dr. Vishva Dixit for his groundbreaking work in the field of programmed cell death.

4 May 2016

Total cessation of GnRH production by hypothalamic neurons can lead to infertility

Individual small RNAs are responsible for controlling the expression of gonadoliberin or GnRH (Gonadotropin-Releasing Hormone), a neurohormone that controls sexual maturation, the appearance of puberty, and fertility in adults.

3 May 2016

Understanding effects of freeze-thawing, intravenous delivery on MSC function

Before the therapeutic potential of using human tissue-derived mesenchymal stromal cells (MSC) to treat immune and degenerative diseases can be fully determined, the effects of freeze-thawing and intravenous delivery on MSC function must be understood.

3 May 2016

New investigational inhibitor JQEZ5 can block specific molecular malfunctions driving cancer

In a step forward in the push for targeted treatments that can block the specific molecular malfunctions driving cancer, University of North Carolina Lineberger Comprehensive Cancer Center researchers have demonstrated how a genetic mutation can drive the most common type of lymphoma as well as melanoma, the deadliest form of skin cancer.

3 May 2016

Combination of existing chemotherapy drugs can reduce breast cancer stem cells, improve survival

Two existing chemotherapy drugs appear to be a powerful pair in targeting errant stem cells that are making breast cancer and enabling its spread and recurrence, scientists report.

3 May 2016

Study opens door for new opportunities in finding antidotes to nerve agent sarin

The nerve agent sarin causes a deadly overstimulation of the nervous system that can be stopped if treated with an antidote within minutes of poisoning. Today, a ground-breaking study has been published in PNAS, which in detail describes how such a drug works. Researchers at the Swedish Defence Research Agency, Umea University and in Germany are behind the study.

3 May 2016

Researchers discover new function of genes in Fanconi anemia pathway

Researchers from UT Southwestern Medical Center have identified an important new function of genes in the Fanconi anemia pathway - a finding that could have implications for development of new therapies to treat this disorder and some cancers.

3 May 2016

Increased fitness can normalize platelet function quickly

Women with poor physical fitness display significantly higher platelet activation than women with average to very good fitness. That is the major finding of a study of 62 young women, conducted by the research groups of Ivo Volf and Rochus Pokan and sponsored by the Austrian Heart Foundation. Platelet (thrombocyte) activation can lead to the formation of potentially life-threatening blood clots.

3 May 2016

Positive effects of Mediterranean diet on health of elderly population

Sticking to a Mediterranean style diet might slow down ageing finds the EU funded project NU-AGE. At a recent conference in Brussels, researchers presented that a NU-AGE Mediterranean style diet, tested in the project, significantly decreased the levels of the protein known as C-reactive protein, one of the main inflammatory marker linked with the ageing process

3 May 2016

Researchers examine critical role of hypoxia in induction, amplification of FOP lesions

The cellular response to the lack of oxygen fans the flames of flare-ups in a rare bone disorder. In fibrodysplasia ossificans progressiva (FOP), a mutation triggers bone growth in muscles, which limits motion, breathing, and swallowing, among a host of progressive symptoms.

3 May 2016

Brain receptor that initiates adolescent synaptic pruning appears to go awry in autism, schizophrenia

Research led by SUNY Downstate Medical Center has identified a brain receptor that appears to initiate adolescent synaptic pruning, a process believed necessary for learning, but one that appears to go awry in both autism and schizophrenia.

3 May 2016

Study shows cannabinoid type 2 receptor plays vital role in signal processing of the brain

The cannabinoid type 2 receptor - also called "CB2 receptor" - is a special membrane protein. Its function is to receive chemical signals that control cellular activity. "Until now, this receptor was considered part of the immune system without function in nerve cells.

3 May 2016

New project explores role of mosquitoes in transmission of pathogens in Austria

In the wake of climate change and globalisation, non-indigenous mosquito species establish in Europe together with the pathogens they transmit. A project funded by the Austrian Science Fund FWF is currently investigating mosquito species found in Austria and their role in the transmission of pathogens.

3 May 2016

Medical Science News

New EU project aims to develop models that can help predict behavior of cancer-related signaling pathways

Researchers identify 43 specific genes associated with both autism and cancer

Researchers develop molecule that binds to GAA enzymes key to progress of Pompe disease

Study shows syringe-like device acts as traffic cop directing bacteria to carry out infection

Riluzole drug can reverse key genetic changes linked to Alzheimer's disease

Lumbar drain placement lowers postoperative CSF leak rate for patients undergoing endoscopic endonasal surgery

Study finds link between placenta and offspring bone

Biomedical researcher wins 2016 Gutenberg Research Award for work on programmed cell death

Total cessation of GnRH production by hypothalamic neurons can lead to infertility

Understanding effects of freeze-thawing, intravenous delivery on MSC function

New investigational inhibitor JQEZ5 can block specific molecular malfunctions driving cancer

Combination of existing chemotherapy drugs can reduce breast cancer stem cells, improve survival

Study opens door for new opportunities in finding antidotes to nerve agent sarin

Researchers discover new function of genes in Fanconi anemia pathway

Increased fitness can normalize platelet function quickly

Positive effects of Mediterranean diet on health of elderly population

Researchers examine critical role of hypoxia in induction, amplification of FOP lesions

Brain receptor that initiates adolescent synaptic pruning appears to go awry in autism, schizophrenia

Study shows cannabinoid type 2 receptor plays vital role in signal processing of the brain

New project explores role of mosquitoes in transmission of pathogens in Austria

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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