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New research on EdnrB, Wnt signaling pathways could lead to therapies for skin pigment disorders

A pair of molecular signals controls skin and hair color in mice and humans — and could be targeted by new drugs to treat skin pigment disorders like vitiligo, according to a report by scientists at NYU Langone Medical Center.

29 Apr 2016

New gene testing method can identify mutations, prioritize variants in breast and ovarian cancer genes

A research team led by an award-winning genomicist at Western University has developed a new method for identifying mutations and prioritizing variants in breast and ovarian cancer genes, which will not only reduce the number of possible variants for doctors to investigate, but also increase the number of patients that are properly diagnosed.

29 Apr 2016

Understanding how individuals respond to aspirin

Researchers have learned new information about how different people respond to aspirin, a globally prescribed drug in cardioprotection. The research team, led by scientists at Cardiff University in the United Kingdom and including representatives from the University of Alabama at Birmingham and the University of Colorado, identified more than 5,600 lipids — or fats — in blood platelets and gained new insights into how these cells respond to aspirin.

29 Apr 2016

Changes in the brain make people prone to alcoholism

The brain tissue of persons with alcohol dependence shows a variety of changes compared to non-alcoholic control persons. All alcoholics' brains share some characteristics, but some are exclusive to the brain tissue of anxiety-prone type 1 alcoholics or impulsive type 2 alcoholics, according to a recent study from the University of Eastern Finland.

29 Apr 2016

Studies on role of vitamin A in heart health have drawn opposite conclusions

Vitamin A is involved in many bodily processes, including vision and skin health, but its role in the heart is unclear. While vitamin A is critical for heart development of embryos—vitamin A deficiency during pregnancy leads to an abnormal heart and prenatal death—studies on vitamin A's role in heart health have drawn opposite conclusions.

29 Apr 2016

New version of obesity drug could help people reduce weight without experiencing anxiety, depression

A new version of an obesity drug that caused serious psychiatric side effects could help people lose pounds without experiencing the anxiety, depression and suicidal thoughts previously associated with it. The research, published in Bioorganic and Medicinal Chemistry, shows that the new version of the drug can still work without reaching the brain in rats, avoiding the side effects.

29 Apr 2016

Discovery of shared biological properties among DNA variants may help identify new therapeutic targets

The discovery of shared biological properties among independent variants of DNA sequences offers the opportunity to broaden understanding of the biological basis of disease and identify new therapeutic targets, according to a collaboration between the Perelman School of Medicine at the University of Pennsylvania, the University of Arizona Health Sciences, and Vanderbilt University. The group published their findings this month in npj Genomic Medicine.

29 Apr 2016

Key gene changes reveal four previously unknown conditions within schizophrenia

Changes in key genes clearly define four previously unknown conditions within the umbrella diagnosis of schizophrenia, according to a study led by researchers from NYU Langone Medical Center published online April 28 in EBioMedicine, a Lancet journal. Cases associated with changes in each of the four genes were different from each other in terms of symptoms, intelligence level and other disease features.

29 Apr 2016

Dopamine neuron transplants controlled by designer drug may fight Parkinson's disease in mice

A University of Wisconsin-Madison neuroscientist has inserted a genetic switch into nerve cells so a patient can alter their activity by taking designer drugs that would not affect any other cell. The cells in question are neurons and make the neurotransmitter dopamine, whose deficiency is the culprit in the widespread movement disorder Parkinson's disease.

29 Apr 2016

Cubresa's new NuPET scanner enables simultaneous PET/MRI in existing third-party MRI systems

A compact PET scanner called NuPET has been commercially released for simultaneous preclinical PET (Positron Emission Tomography) and MRI (Magnetic Resonance Imaging) in existing third-party MRI systems.

From Cubresa Inc. 29 Apr 2016

Particle Metrix reports on use of Zetaview particle characterization system at University Hospital of Erlangen

Particle Metrix, developers of versatile particle characterization solutions for the life sciences, report on the work of the Baur Laboratory in the Department of Dermatology at the University Hospital of Erlangen. The Group, which is part of the Translational Research Center at the University, is working to quantify extracellular vesicles in plasma of patients.

29 Apr 2016

University of Kaiserslautern uses JPK NanoWizard AFM to study bacterial interaction with microstructured surfaces

JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, reports on the research into the interaction of bacteria with microstructured surfaces in the Department of Physics at the University of Kaiserslautern in Germany.

From Bruker BioAFM 29 Apr 2016

University of Kaiserslautern uses JPK NanoWizard AFM to study bacterial interaction with microstructured surfaces

From Bruker BioAFM 29 Apr 2016

Study links age-related changes in human pancreas to diabetes development

A Stanford-led national collaboration to procure and analyze human pancreatic tissue from deceased donors illustrates how the organ's function changes as we age, and could point the way toward new diabetes treatments.

29 Apr 2016

Researchers report tumors can continue to grow even without supply of new blood vessels

When medication is used to shut off the oxygen supply to tumor cells, the cells adapt their metabolism in the medium term -- by switching over to producing energy without oxygen. This observation by biomedical scientists at the University of Basel and University Hospital Basel could be used for treatments that can inhibit tumor growth in the long term, as the researchers report in the latest issue of the journal Cell Reports.

29 Apr 2016

New class of cancer-driver gene may serve as unique therapeutic targets, biomarkers in TNBC

The discovery of long non-coding RNA (lncRNA) has dramatically changed the understanding of the biology of diseases such as cancer. The human genome contains about 20,000 protein-coding genes - less than 2 percent of the total - but 70 percent of the genome is made into non-gene-encoding RNA.

29 Apr 2016

Cells have ability to perceive their own shapes, new study shows

Can a cell sense its own shape? Working in the Marine Biological Laboratory's Whitman Center, scientists from Dartmouth College developed an ingenious experiment to ask this question. Their conclusion - Yes - is detailed in a recent paper in the Journal of Cell Biology.

29 Apr 2016

Researchers identify role of darks in visual brain maps

Scientists have been studying how visual space is mapped in the cerebral cortex for many decades under the assumption that the map is equal for lights and darks. Surprisingly, recent work demonstrates that visual brain maps are dark-centric and that, just as stars rotate around black holes in the Universe, lights rotate around darks in the brain representation of visual space.

28 Apr 2016

Single bNAb infusion can protect monkeys from HIV-like virus infection

A single antibody infusion can protect monkeys against infection with an HIV-like virus for up to 23 weeks, researchers have found. The study, published in Nature, was led by scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and The Rockefeller University.

28 Apr 2016

Experimental therapy has over 90% remission rate for advanced leukemia patients

Twenty-seven of 29 patients with an advanced type of leukemia that had proved resistant to multiple other forms of therapy went into remission after their T cells (disease-fighting immune cells) were genetically engineered to fight their cancers.

28 Apr 2016

Medical Science News

New research on EdnrB, Wnt signaling pathways could lead to therapies for skin pigment disorders

New gene testing method can identify mutations, prioritize variants in breast and ovarian cancer genes

Understanding how individuals respond to aspirin

Changes in the brain make people prone to alcoholism

Studies on role of vitamin A in heart health have drawn opposite conclusions

New version of obesity drug could help people reduce weight without experiencing anxiety, depression

Discovery of shared biological properties among DNA variants may help identify new therapeutic targets

Key gene changes reveal four previously unknown conditions within schizophrenia

Dopamine neuron transplants controlled by designer drug may fight Parkinson's disease in mice

Cubresa's new NuPET scanner enables simultaneous PET/MRI in existing third-party MRI systems

Particle Metrix reports on use of Zetaview particle characterization system at University Hospital of Erlangen

University of Kaiserslautern uses JPK NanoWizard AFM to study bacterial interaction with microstructured surfaces

University of Kaiserslautern uses JPK NanoWizard AFM to study bacterial interaction with microstructured surfaces

Study links age-related changes in human pancreas to diabetes development

Researchers report tumors can continue to grow even without supply of new blood vessels

New class of cancer-driver gene may serve as unique therapeutic targets, biomarkers in TNBC

Cells have ability to perceive their own shapes, new study shows

Researchers identify role of darks in visual brain maps

Single bNAb infusion can protect monkeys from HIV-like virus infection

Experimental therapy has over 90% remission rate for advanced leukemia patients

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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