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First-ever nivolumab drug trial for rare, malignant SCCA shows positive results

A rare malignancy known as squamous cell carcinoma of the anal canal (SCCA) is on the increase, and now researchers have reported results of the first-ever phase II clinical trial results for treatment with the immunotherapy drug nivolumab.

18 Apr 2016

Research finds high prevalence of smoking, low cessation rates in people with schizophrenia

Smoking addiction in schizophrenia can be explained by significantly increased activation of the ventro-medial prefrontal cortex (vmPFC), a region involved in the brain reward system. These new data, the result of a study by researchers at the Institut universitaire en santé mentale de Montréal and the University of Montreal confirms the tendency to smoke and low smoking cessation rates of people with schizophrenia.

18 Apr 2016

Mouse model can help identify new, more effective melanoma-preventing agents

Application of sun protection factor 30 (SPF30) sunscreen prior to exposure to ultraviolet-B (UVB) light delayed melanoma onset in a mouse model of the disease, according to data from a team at The Ohio State University Comprehensive Cancer Center Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. This data suggest that the mouse model can be used to identify new, more effective melanoma-preventing agents, according to principal investigator Christin Burd, PhD.

18 Apr 2016

Scientists develop innovative technique to deliver cancer drugs deep into tumour cells

Scientists at Nanyang Technological University (NTU Singapore) have invented a new way to deliver cancer drugs deep into tumour cells.

18 Apr 2016

African sleeping sickness parasite has defence mechanism against potential pharmaceuticals

Researchers from Umea University in Sweden have discovered that the single-celled parasite causing African sleeping sickness has a defence mechanism against potential pharmaceuticals under development against the disease. The deadly parasite has an enzyme that can cleave and hence disarm adenosine analogue pharmaceuticals. This according to a study recently published in the Journal of Biological Chemistry.

18 Apr 2016

Survivin inhibitor with chemotherapy provides therapeutic advantage for Rb cells, tumors

Researchers at The Saban Research Institute of Children's Hospital Los Angeles (CHLA) have demonstrated that targeting survivin - a protein that inhibits apoptosis or cell death - enhances the effectiveness of chemotherapy in cells and mouse models of retinoblastoma (Rb), the most common malignant tumor of the eye in children.

18 Apr 2016

Scientists identify unique memory suppressor gene that could provide clues for new Alzheimer’s disease treatments

While research has identified hundreds of genes required for normal memory formation, genes that suppress memory are of special interest because they offer insights into how the brain prioritizes and manages all of the information, including memories, that it takes in every day.

18 Apr 2016

Study supports screening for HLA-B*5801 gene variant in Asian, black patients with gout

A multi-institutional study led by a Massachusetts General Hospital investigator finds significant racial disparities in the risk that patients being treated for gout will develop a serious, sometimes life-threatening adverse reaction to the most commonly prescribed medication. The increased risk closely correlates with the frequency of a gene variant previously associated with that adverse reaction, supporting recommendations to screen for that variant in patients from those populations.

16 Apr 2016

Flat adenomas may warrant keeping closer eye on patients at risk for colorectal cancer

Being on the lookout for certain features of polyps may help physicians keep a closer eye on patients at risk for colorectal cancer.

16 Apr 2016

Researchers find that children develop self-control mechanisms by age 3

University of Texas at Arlington researchers have found that by age 3 environmental influences such as parenting are relevant factors in the development of toddlers' self-control when they are asked not to do something they want to do, such as run into the street or eat a forbidden snack.

16 Apr 2016

Intestinal bacteria can be used to reduce cancer risk, reveals UCLA study

Researchers have shown that various types of intestinal bacteria might be factors in both causing and preventing obesity, and in other conditions and diseases. Now, a UCLA study suggests that it could also potentially be used to reduce the risk for some types of cancer.

16 Apr 2016

Older men receiving testosterone therapy less likely to return to hospital

A new large-scale population-based study from The University of Texas Medical Branch at Galveston showed for the first time that older men using testosterone therapy were less likely to have complications that require them to go back to the hospital within a month of being discharged than men not using this therapy. The study is currently available in Mayo Clinic Proceedings.

16 Apr 2016

Cholesterol-fighting drug molecule can kill prostate cancer cells

Standard treatment for prostate cancer can include chemotherapy that targets receptors on cancer cells. However, drug-resistant cancer cells can emerge during chemotherapy, limiting its effectiveness as a cancer-fighting agent. Researchers at the University of Missouri have proven that a compound initially developed as a cholesterol-fighting molecule not only halts the progression of prostate cancer, but also can kill cancerous cells.

16 Apr 2016

Scientists find way to control behaviour of cardiomyocytes using laser radiation

Scientists from MIPT's Laboratory of the Biophysics of Excitable Systems have discovered how to control the behaviour of heart muscle cells (cardiomyocytes) using laser radiation; this study will help scientists to better understand the mechanisms of the heart and could ultimately provide a method of treating arrhythmia. The paper has been published in the journal PLOS ONE.

16 Apr 2016

Study shows noise impairs tactile abilities of premature babies

Premature birth is a harsh change of environment for a baby. Until birth, the baby is confined to the mother's womb, surrounded by soft lighting and filtered noise. When infants are born, they are attacked by several visual, sound, and tactile stimulations.

16 Apr 2016

International panel reclassifies a type of thyroid tumor to reduce cancer overdiagnosis

Led by researchers at the University of Pittsburgh School of Medicine, an international panel of pathologists and clinicians has reclassified a type of thyroid cancer to reflect that it is noninvasive and has a low risk of recurrence. The name change, described today in JAMA Oncology, is expected to reduce the psychological and medical consequences of a cancer diagnosis, potentially affecting thousands of people worldwide.

16 Apr 2016

Study offers clearer understanding of how obese people can sustain weight loss

Maintaining a stable weight loss is the biggest struggle for obese individuals, yet new research from University of Copenhagen have allowed researchers new insights into the complex processes involved in obesity and especially weight loss in obesity. It is now possible to offer overweight people a clearer understanding of how to sustain weight loss.

16 Apr 2016

Scientists identify human protein that weakens immune response to HIV, other viruses

Scientists at the University of North Carolina School of Medicine and Sanford Burnham Prebys Medical Discovery Institute have identified a human (host) protein that weakens the immune response to HIV and other viruses. The findings, published today in Cell Host & Microbe, have important implications for improving HIV antiviral therapies, creating effective viral vaccines, and advance a new approach to treat cancer.

16 Apr 2016

MicroRNAs circulating in blood could lead to first diagnostic test for asthma

People with asthma have telltale molecules circulating in their blood, say researchers at Penn State College of Medicine. The discovery could lead to the first diagnostic blood test for asthma, as well as more targeted treatments for the condition.

16 Apr 2016

Scientists discover underlying mechanisms of nerve damage

Recent research by Sandra Rieger, Ph.D., of the MDI Biological Laboratory identifying the underlying mechanisms of peripheral neuropathy, or nerve damage, has raised the prospect that drug therapies can be developed for the treatment of this condition, which causes pain, numbness and/or tingling in the hands and feet. The research was published March 28 in the Proceedings of the National Academy of Sciences.

16 Apr 2016

Medical Science News

First-ever nivolumab drug trial for rare, malignant SCCA shows positive results

Research finds high prevalence of smoking, low cessation rates in people with schizophrenia

Mouse model can help identify new, more effective melanoma-preventing agents

Scientists develop innovative technique to deliver cancer drugs deep into tumour cells

African sleeping sickness parasite has defence mechanism against potential pharmaceuticals

Survivin inhibitor with chemotherapy provides therapeutic advantage for Rb cells, tumors

Scientists identify unique memory suppressor gene that could provide clues for new Alzheimer’s disease treatments

Study supports screening for HLA-B*5801 gene variant in Asian, black patients with gout

Flat adenomas may warrant keeping closer eye on patients at risk for colorectal cancer

Researchers find that children develop self-control mechanisms by age 3

Intestinal bacteria can be used to reduce cancer risk, reveals UCLA study

Older men receiving testosterone therapy less likely to return to hospital

Cholesterol-fighting drug molecule can kill prostate cancer cells

Scientists find way to control behaviour of cardiomyocytes using laser radiation

Study shows noise impairs tactile abilities of premature babies

International panel reclassifies a type of thyroid tumor to reduce cancer overdiagnosis

Study offers clearer understanding of how obese people can sustain weight loss

Scientists identify human protein that weakens immune response to HIV, other viruses

MicroRNAs circulating in blood could lead to first diagnostic test for asthma

Scientists discover underlying mechanisms of nerve damage

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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