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High levels of COMP protein may lead to worse breast cancer prognosis

Research from Lund University in Sweden shows that the protein COMP, which mainly exists in cartilage, can also be found in breast cancer tumours in patients with a poor prognosis. Studies on mice also showed that COMP contributed to the development and metastasis of the breast cancer.

13 Apr 2016

Common antihistamine may partially reverse damage to visual system in multiple sclerosis patients

A common antihistamine used to treat symptoms of allergies and the common cold, called clemastine fumarate, partially reversed damage to the visual system in people with multiple sclerosis (MS) in a preliminary study released today that will be presented at the American Academy of Neurology's 68th Annual Meeting in Vancouver, Canada, April 15 to 21, 2016.

13 Apr 2016

Umea University researchers find link between levels of DNA building blocks and colon cancer

When cells divide, the proper balance between the four DNA building blocks is required in order for the DNA to be copied without the introduction of potentially harmful mutations. Researchers at Umea University in Sweden have now shown a connection between levels of DNA building blocks - dNTPs - and colon cancer. This discovery has been published in the Proceedings of the National Academy of Sciences.

13 Apr 2016

Scientists use FAN1 knockout mice to refine detailed mechanisms involved in damaged DNA repair

Like jewels in a vault, our precious genetic material is stored in the nucleus of a cell--sequestered away from potentially damaging cellular components and toxins so that no harm can come to it. Yet over the course of a life moving through this world, our DNA does get damaged, and our cells have a host of complicated repair mechanisms to deal with such injuries.

13 Apr 2016

Researchers reach milestone in developing non-hormonal approach to male contraception

Researchers studying strategies to develop a non-hormonal approach to male contraception have reached an important milestone in their work, discovering a way to produce a key enzyme found only in sperm in sufficient quantities that they can begin designing drugs to stop the sperm from swimming to the egg.

13 Apr 2016

Depression combined with behavioral, metabolic symptoms increases risk of type 2 diabetes

Depression may compound the risk of developing type 2 diabetes in people with such early warning signs of metabolic disease as obesity, high blood pressure and unhealthy cholesterol levels, according to researchers from McGill University, l'Université de Montréal, the Institut de recherches cliniques de Montréal and the University of Calgary.

13 Apr 2016

Researchers observe increase in antibiotic resistance genes

Around the world, antibiotic use and resistance is increasing while the discovery of new antibiotics has nearly halted.

13 Apr 2016

Inserm study reveals potential of secondary system to improve heart function

Heart failure affects over one million people in France. Although the blood system is the first to have been explored for the purpose of improving heart function, a study by Inserm has revealed the potential of a secondary system that had previously received scant attention.

13 Apr 2016

Manipulation of signals in nervous system can enhance recovery after traumatic injury

Neurobiologists at UC San Diego have discovered how signals that orchestrate the construction of the nervous system also influence recovery after traumatic injury. They also found that manipulating these signals can enhance the return of function.

12 Apr 2016

Bacteroidia pilins prevalent in human gut and mouth form new type of pili to cling to hosts

Many bacteria interact with their environment through hair-like structures known as pili, which attach to and help mediate infection of host organisms, among other things. Now a U.S.-Japanese research team, including scientists from the Department of Energy's SLAC National Accelerator Laboratory, has discovered that certain bacteria prevalent in the human gut and mouth assemble their pili in a previously unknown way - information that could potentially open up new ways of fighting infection.

12 Apr 2016

Six newly identified proteins may help potentially unlock new insights into aging-related diseases

A group of six newly discovered proteins may help to divulge secrets of how we age, potentially unlocking new insights into diabetes, Alzheimer's, cancer, and other aging-related diseases.

12 Apr 2016

Distribution of c-Myc protein during asymmetric cell division influences fate, roles of activated T cells

The fates of immune cells can be decided at the initial division of a cell. Researchers at St. Jude Children's Research Hospital have discovered that the production of daughter cells with different roles in the immune system is driven by the lopsided distribution of the signaling protein c-Myc. Nudging c-Myc in one direction or the other could make vaccines more effective or advance immunotherapies for cancer treatment. The research appears online today in the scientific journal Nature.

12 Apr 2016

Cell-signaling protein holds key to understanding autoantibody formation in lupus patients

A signaling molecule called interferon gamma could hold the key to understanding how harmful autoantibodies form in lupus patients. The finding could lead to new treatments for the chronic autoimmune disease, said researchers at Penn State College of Medicine.

12 Apr 2016

Alternative splicing regulates MALT1 protein to have stronger or weaker effect on immune system

The protein MALT1 is an important switch in immune cells and affects their activity. Researchers at Helmholtz Zentrum München report in 'Nature Communications' that this activation is not always equally strong. Through alternative splicing, two variants of the protein may arise which have a stronger or weaker effect on the immune system. Understanding this process is important for the pharmacological use of MALT1.

12 Apr 2016

New biomarker discovery could improve chances of developing effective TB vaccine

A team of scientists led by Oxford University have made a discovery that could improve our chances of developing an effective vaccine against Tuberculosis.

12 Apr 2016

New European standard method can help measure inorganic arsenic content in foods

A new European standard method to determine the content of inorganic arsenic in foodstuffs has been developed at the National Food Institute, Technical University of Denmark. Inorganic arsenic is carcinogenic according to the World Health Organization, WHO. Being able to accurately measure the substance in different foods is necessary to ensure that the content is below the maximum levels recently set by the European Commission to protect consumers.

12 Apr 2016

Bonn mathematicians develop new model for cancer immunotherapy

Mathematicians and physicians at the University of Bonn have developed a new model for immunotherapy of cancer. The method could help to develop new treatment strategies and to understand why some approaches do not work with certain tumors. The study is now appearing in the technical journal "Scientific Reports".

12 Apr 2016

$New sensitive detection method could help measure subfractions of HDL$

New sensitive detection method could help measure subfractions of HDL

High-density lipoprotein (HDL) is often referred to as good cholesterol: high levels of HDL are associated with lower risk of cardiovascular disease. But many clinical outcome trials for drugs that raise HDL levels have failed to show significant benefits for trial participants.

12 Apr 2016

Abnormally active Rab5 protein leads to early development of neurodegenerative disease

Writing in the April 11 issue of The Journal of Clinical Investigation, researchers at University of California, San Diego School of Medicine say abnormalities in a protein that helps transport and sort materials inside cells are linked to axonal dysfunction and degeneration of neurons in Alzheimer's disease (AD) and Down syndrome (DS).

12 Apr 2016

Researchers investigate biochemical, physiological characteristics of facial and extraocular muscles

In a new study, a research team at Basel University Hospital in Switzerland investigates the biochemical and physiological characteristics of orbicularis oculi, a group of facial muscles that control the eyelids and are selectively spared or involved in different neuromuscular disorders. What they found also helps to explain why another set of muscles—the extraocular muscles that control the movement of the eye—are not affected by Duchenne muscular dystrophy, congenital muscular dystrophy, and aging.

12 Apr 2016

Medical Science News

High levels of COMP protein may lead to worse breast cancer prognosis

Common antihistamine may partially reverse damage to visual system in multiple sclerosis patients

Umea University researchers find link between levels of DNA building blocks and colon cancer

Scientists use FAN1 knockout mice to refine detailed mechanisms involved in damaged DNA repair

Researchers reach milestone in developing non-hormonal approach to male contraception

Depression combined with behavioral, metabolic symptoms increases risk of type 2 diabetes

Researchers observe increase in antibiotic resistance genes

Inserm study reveals potential of secondary system to improve heart function

Manipulation of signals in nervous system can enhance recovery after traumatic injury

Bacteroidia pilins prevalent in human gut and mouth form new type of pili to cling to hosts

Six newly identified proteins may help potentially unlock new insights into aging-related diseases

Distribution of c-Myc protein during asymmetric cell division influences fate, roles of activated T cells

Cell-signaling protein holds key to understanding autoantibody formation in lupus patients

Alternative splicing regulates MALT1 protein to have stronger or weaker effect on immune system

New biomarker discovery could improve chances of developing effective TB vaccine

New European standard method can help measure inorganic arsenic content in foods

Bonn mathematicians develop new model for cancer immunotherapy

New sensitive detection method could help measure subfractions of HDL

Abnormally active Rab5 protein leads to early development of neurodegenerative disease

Researchers investigate biochemical, physiological characteristics of facial and extraocular muscles

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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