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Bonn researchers use reprogrammed neurons for drug testing in Alzheimer patients

Why do certain Alzheimer medications work in animal models but not in clinical trials in humans? A research team from the University of Bonn and the biomedical enterprise LIFE & BRAIN GmbH has been able to show that results of established test methods with animal models and cell lines used up until now can hardly be translated to the processes in the human brain.

9 Dec 2013

Skin is capable of communicating with liver, say researchers

Researchers from the University of Southern Denmark have discovered that the skin is capable of communicating with the liver. The discovery has surprised the scientists, and they say that it may help our understanding of how skin diseases can affect the rest of the body.

9 Dec 2013

Downregulation of caveolin-1 contributes to synaptic plasticity deficit in hippocampus of aged rats

Caveolin-1 may be a new target for interfering with age-dependent decline in synaptic plasticity. To explore the relationship between synaptic plasticity in the aging process and changes in learning and memory, Dr. Yang Liu and coworkers from the First Affiliated Hospital, Dalian Medical University, China examined synaptophysin expression in the hippocampus, cortex and cerebellum of rats at different ages, and analyzed the association between synaptophysin expression and cognition and behaviors.

9 Dec 2013

NIH scientists film early concussion damage and describe brain's response to injury

There is more than meets the eye following even a mild traumatic brain injury. While the brain may appear to be intact, new findings reported in Nature suggest that the brain's protective coverings may feel the brunt of the impact.

9 Dec 2013

Decreased bacterial diversity in gut linked with CRC risk

Decreased diversity in the microbial community found in the human gut is associated with colorectal cancer, according to a new study published December 6 in the Journal of the National Cancer Institute.

9 Dec 2013

Scientists identify gene encoding hormone to treat heart diseases

Scientists at A*STAR's Institute of Medical Biology (IMB) and Institute of Molecular and Cellular Biology (IMCB) have identified a gene encoding a hormone that could potentially be used as a therapeutic molecule to treat heart diseases.

9 Dec 2013

Saudi Human Genome Program to study genetic basis of all disease in the Kingdom

The King Abdulaziz City for Science and Technology, Saudi Arabia's national funding agency, and Life Technologies Corporation today announce The Saudi Human Genome Program – a national research project to study the genetic basis of all disease in the Kingdom and throughout the Middle East and use the findings to offer the ultimate personal care in Saudi Arabia.

8 Dec 2013

Scientists recommend testing for Pearson syndrome in patients with congenital anemia

Some babies diagnosed with and treated for a bone marrow failure disorder, called Diamond Blackfan Anemia, may actually be affected by a very rare anemia syndrome that has a different disease course and treatment, say scientists from Dana-Farber/Boston Children's Cancer and Blood Disorders Center.

8 Dec 2013

Study provides possible therapeutic strategy for Alzheimer's disease via progesterone

Steroid hormones and their metabolites within the central nervous system are commonly defined as neuroactive steroids or neurosteroids. Although neuroactive steroids have been shown to improve learning and memory ability and protect against amyloid beta peptide-induced neurotoxicity, changes in their level during Alzheimer's disease and their role in Aβ-mediated cognitive impairment remain elusive given the limitation in sample sizes and analysis methods.

8 Dec 2013

PKM2 protein controls mitosis, saving cancer cells from death and promoting brain tumor growth

Researchers have caught a protein they previously implicated in a variety of cancer-promoting roles performing a vital function in cell division, survival and development of brain tumors.

8 Dec 2013

New study reports first evidence of specific molecular changes in the body with meditation

With evidence growing that meditation can have beneficial health effects, scientists have sought to understand how these practices physically affect the body.

6 Dec 2013

NYU Langone Medical Center researchers find link between gut bacteria and colorectal cancer

In one of the largest epidemiological studies of human gut bacteria and colorectal cancer ever conducted, a team of researchers at NYU Langone Medical Center has found a clear association between gut bacteria and colorectal cancer. The study, published today in the Journal of the National Cancer Institute, discovered that colorectal cancer patients had fewer beneficial bacteria and more harmful bacteria than people without the disease.

6 Dec 2013

Researchers illuminate inner workings of enzymes placed inside the outer envelopes of cells

For what is believed to be the first time, researchers at The Johns Hopkins University have illuminated the inner workings of an important class of enzymes located inside the outer envelopes of cells. Much to their surprise, they report, these protein cutters, called rhomboid proteases, are entirely different than nearly every other type of enzyme studied, showing no attraction to the proteins they cut and being extremely slow in making their cuts.

6 Dec 2013

Study uncovers novel mechanism by which glioblastoma evades targeted therapies

A Ludwig Cancer Research study has uncovered an entirely novel mechanism by which glioblastoma, the most common kind of brain cancer, evades targeted therapies. Published in the current issue of the journal Science, the paper describes how GBM tumor cells essentially hide the signaling molecule targeted by such therapies, adding a layer of complexity to current models of drug resistance in cancer.

6 Dec 2013

Innovative DNA engineering technique discovers potential functions hidden within bacterial genomes

A group of University of Illinois researchers, led by Centennial Chair Professor of the Department of Chemical and Biomolecular Engineering Huimin Zhao, has demonstrated the use of an innovative DNA engineering technique to discover potentially valuable functions hidden within bacterial genomes.

6 Dec 2013

Study reports new links between brain cell activity and choices where two options have equal appeal

Life presents us with choices all the time: salad or pizza for lunch? Tea or coffee afterward? How we make these everyday decisions has been a topic of great interest to economists, who have devised theories about how we assign values to our options and use those values to make decisions.

6 Dec 2013

Understanding biochemical mechanisms associated with memory formation

A discovery by a research team led by Dr. Ryohei Yasuda at the Max Planck Florida Institute for Neuroscience has significantly advanced basic understanding of biochemical mechanisms associated with how memories are formed.

6 Dec 2013

Researchers discover biological mechanism that allows brain tumor cells to escape from drugs

Researchers from UCLA's Jonsson Comprehensive Cancer Center have discovered a biological mechanism that allows brain tumor cells to escape from the drugs designed to target them, resulting in drug resistance. The study was published in the December 5, 2013 online issue of Science.

6 Dec 2013

Researchers produce erythrocyte progenitor cells by transducing two genes into iPS and ES cells

By transducing two genes (c-MYC and BCL-XL) into iPS cells and ES cells, a Kyoto University research team led by Prof. Koji Eto at CiRA has succeeded in producing erythrocyte progenitor cells with almost unlimited ability to replicate in vitro, which they then differentiated successfully into mature erythrocytes. Although these erythrocytes consisted mostly of fetal-type hemoglobin, they were confirmed to have oxygen-carrying capacity and to have circulatory capacity following transfusion into mice.

6 Dec 2013

Study reveals that brain cancer cells resist therapy by dialing down gene mutation targeted by drugs

A team of scientists, led by principal investigator Paul S. Mischel, MD, a member of the Ludwig Institute for Cancer Research and professor in the Department of Pathology at the University of California, San Diego School of Medicine, has found that brain cancer cells resist therapy by dialing down the gene mutation targeted by drugs, then re-amplify that growth-promoting mutation after therapy has stopped.

6 Dec 2013

Medical Science News

Bonn researchers use reprogrammed neurons for drug testing in Alzheimer patients

Skin is capable of communicating with liver, say researchers

Downregulation of caveolin-1 contributes to synaptic plasticity deficit in hippocampus of aged rats

NIH scientists film early concussion damage and describe brain's response to injury

Decreased bacterial diversity in gut linked with CRC risk

Scientists identify gene encoding hormone to treat heart diseases

Saudi Human Genome Program to study genetic basis of all disease in the Kingdom

Scientists recommend testing for Pearson syndrome in patients with congenital anemia

Study provides possible therapeutic strategy for Alzheimer's disease via progesterone

PKM2 protein controls mitosis, saving cancer cells from death and promoting brain tumor growth

New study reports first evidence of specific molecular changes in the body with meditation

NYU Langone Medical Center researchers find link between gut bacteria and colorectal cancer

Researchers illuminate inner workings of enzymes placed inside the outer envelopes of cells

Study uncovers novel mechanism by which glioblastoma evades targeted therapies

Innovative DNA engineering technique discovers potential functions hidden within bacterial genomes

Study reports new links between brain cell activity and choices where two options have equal appeal

Understanding biochemical mechanisms associated with memory formation

Researchers discover biological mechanism that allows brain tumor cells to escape from drugs

Researchers produce erythrocyte progenitor cells by transducing two genes into iPS and ES cells

Study reveals that brain cancer cells resist therapy by dialing down gene mutation targeted by drugs

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