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Two pharma companies plan international trials into targeted cancer treatments in the UK

A Cancer Research UK initiative to improve cancer gene testing has prompted two pharmaceutical companies to plan pioneering international trials into targeted cancer treatments in the UK.

2 Jun 2012

Exercise reduces expression of cytokines and alleviates neuropathic pain

Exercise helps to alleviate pain related to nerve damage (neuropathic pain) by reducing levels of certain inflammation-promoting factors, suggests an experimental study in the June issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

2 Jun 2012

Agendia launches ColoPrint microarray-based 18-gene expression signature for colon cancer

Agendia, an innovative molecular cancer diagnostics company and leader in personalized medicine, today announced the launch of its ColoPrint microarray-based 18-gene expression signature for predicting the risk of distant recurrence for stage II colon cancer patients who have undergone surgery.

2 Jun 2012

Study identifies new genetic factor associated with lean diabetes

Type 2 diabetes is popularly associated with obesity and a sedentary lifestyle. However, just as there are obese people without type 2 diabetes, there are lean people with the disease.

2 Jun 2012

Study provides novel mechanism of action of anti-cancer compound: perifosine

Aeterna Zentaris Inc. today announced that an article published in the May 2012 issue of Plos One, outlines a novel mechanism of action of the Company's oral anti-cancer compound, perifosine, which could provide a rationale for a novel approach to the treatment of Malignant Pleural Mesothelioma (MMe), an aggressive type of cancer associated with exposure to asbestos.

2 Jun 2012

Study identifies several proteins as new therapeutic targets and biomarkers for kidney cancer

Using blood, urine and tissue analysis of a unique mouse model, a team led by UC Davis researchers has identified several proteins as diagnostic biomarkers and potential therapeutic targets for kidney cancer. Subject to follow-up validation testing, inhibition of these proteins and several related pathways holds promise as a form of therapy to slow the growth of kidney tumors.

2 Jun 2012

Inhibiting IRE1α-XBP1 pathway impacts survival of myeloma cells

Results published in Blood, the official journal of the American Society of Hematology, confirm that inhibition of the IRE1α-XBP1 pathway impacts the survival of myeloma cells, suggesting a promising therapeutic option in multiple myeloma.

2 Jun 2012

Scientists discover previously unrecognized signaling network disrupted in lung cancer

A team of researchers led by Dr. Goutham Narla at Case Western Reserve University School of Medicine in collaboration with scientists at Mount Sinai School of Medicine in New York, have discovered a previously unrecognized signaling network disrupted in lung cancer that can be turned back on by a novel combination of two previously approved FDA drugs.

2 Jun 2012

Breakthrough in nanotechnology could make laboratory tests more sensitive

A laboratory test used to detect disease and perform biological research could be made more than 3 million times more sensitive, according to researchers who combined standard biological tools with a breakthrough in nanotechnology.

2 Jun 2012

Glucocorticoid steroids in intelligent medicine specifically hits relevant cells

Scientists at Aarhus University, Denmark in collaboration with the biotech company Cytoguide now publish a key to use glucocorticoid steroids in a kind of intelligent medicine that specifically hits the relevant cells. Data are based on rodent studies but if this principle is translated to humans it may greatly improve todays hazardous treatment with this type of potent steroids.

1 Jun 2012

Affymetrix, Leica Microsystems enter worldwide collaboration on RNA ISH analysis

Affymetrix, Inc. and Leica Microsystems are pleased to announce a world-wide collaboration that automates Affymetrix' QuantiGene ViewRNA ISH Tissue Assay on the Leica BOND RX staining platform for research applications.

1 Jun 2012

Distinctive protein pathways in certain leukemia patients

Scientists at Rice University and the University of Texas MD Anderson Cancer Center have successfully profiled protein pathways found to be distinctive to leukemia patients with particular variants of the disease.

1 Jun 2012

Formation of blood vessels in tumors attacked from two angles

As soon as they have grown to pinhead size, tumors rely on the formation of new blood vessels - a process which is scientifically called angiogenesis. Interfering with this process (antiangiogenesis) is considered to be a promising approach in cancer medicine. However, those drugs that are already available for preventing the sprouting of new blood capillaries have failed to fulfill the high expectations placed on them.

1 Jun 2012

Promega launches novel luciferase more versatile than current bioluminescent enzyme

Promega Corporation announces the launch of a novel luciferase that is smaller, brighter, and more versatile than any current bioluminescent enzyme. These attributes of the NanoLuc Luciferase provide new capabilities in reporter assays with potential in biologically complex applications that require greater sensitivity.

1 Jun 2012

Molecular structure of APP protein could lead to new therapeutics for AD

The molecular structure of a protein involved in Alzheimer's disease - and the surprising discovery that it binds cholesterol - could lead to new therapeutics for the disease, Vanderbilt University investigators report in the June 1 issue of the journal Science.

1 Jun 2012

Scientists discover genetic basis for CLOVES syndrome

Using advanced technologies for rapidly sequencing and analyzing DNA from clinical and pathologic samples, a multidisciplinary research team consisting of geneticists, pathologists and surgeons at Boston Children's Hospital has identified the genetic basis for CLOVES syndrome, a rare congenital malformation and overgrowth disorder.

1 Jun 2012

Researchers discover binding partner of TDF hormone

Researchers at Clarkson University in Potsdam, N.Y., led by Chemistry & Biomolecular Science Professor Costel C. Darie, in collaboration with researchers from Columbia University, have now found the binding partner of TDF, a pituitary hormone that had previously been shown to reduce cancer progression in breast cancer cells, in prostate cancer as well.

1 Jun 2012

JMC publishes results from Rexahn’s RX-3117 preclinical cancer study

Rexahn Pharmaceuticals, Inc., a clinical stage pharmaceutical company developing and commercializing potential best in class oncology and CNS therapeutics, today announced the publication of a research article in Journal of Medicinal Chemistry on the anti-tumor activity of its RX-3117 compound.

1 Jun 2012

Personalized medicine and the Human Genome Project

It’s nearly a decade since the completion of the Human Genome Project, (1) which aimed to sequence the complete human genome.

1 Jun 2012

Scientists determine 3-D structure of two circadian rhythm proteins

Howard Hughes Medical Institute scientists have determined the three-dimensional structure of two proteins that help keep the body's clocks in sync.

1 Jun 2012

Medical Science News

Two pharma companies plan international trials into targeted cancer treatments in the UK

Exercise reduces expression of cytokines and alleviates neuropathic pain

Agendia launches ColoPrint microarray-based 18-gene expression signature for colon cancer

Study identifies new genetic factor associated with lean diabetes

Study provides novel mechanism of action of anti-cancer compound: perifosine

Study identifies several proteins as new therapeutic targets and biomarkers for kidney cancer

Inhibiting IRE1α-XBP1 pathway impacts survival of myeloma cells

Scientists discover previously unrecognized signaling network disrupted in lung cancer

Breakthrough in nanotechnology could make laboratory tests more sensitive

Glucocorticoid steroids in intelligent medicine specifically hits relevant cells

Affymetrix, Leica Microsystems enter worldwide collaboration on RNA ISH analysis

Distinctive protein pathways in certain leukemia patients

Formation of blood vessels in tumors attacked from two angles

Promega launches novel luciferase more versatile than current bioluminescent enzyme

Molecular structure of APP protein could lead to new therapeutics for AD

Scientists discover genetic basis for CLOVES syndrome

Researchers discover binding partner of TDF hormone

JMC publishes results from Rexahn’s RX-3117 preclinical cancer study

Personalized medicine and the Human Genome Project

Scientists determine 3-D structure of two circadian rhythm proteins

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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