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Neonatal hepatocytes show better thawing recovery than hepatocytes from adult livers

A research team in Spain has developed high-yield preparations of viable hepatocytes (liver cells) isolated for transplantation from cryopreserved (frozen), banked neonatal livers that ranged in age from one day to 23 days.

18 Sep 2013

Researchers reveal mechanisms that connect Mfn2 protein to endoplasmic reticulum stress

Each cell in an organism has a sensor that measures the health of its "internal" environment. This "alarm" is found in the endoplasmic reticulum, which is able to sense cellular stress and trigger either rescue responses or the death of the cell.

18 Sep 2013

University of Chicago researchers awarded NIH grant to develop novel multiple sclerosis treatment

Researchers from the University of Chicago have been awarded a five-year, $1.5 million grant from the National Institutes of Health to develop stimulated dendritic cell-derived exosomes that show remarkable promise as a treatment for multiple sclerosis and other neurological diseases involving loss of myelin, the insulation around nerve fibers.

18 Sep 2013

Study: Carbonation alters brain's perception of sweetness

Carbonation, an essential component of popular soft drinks, alters the brain's perception of sweetness and makes it difficult for the brain to determine the difference between sugar and artificial sweeteners, according to a new article in Gastroenterology, the official journal of the American Gastroenterological Association.

18 Sep 2013

Scientists isolate, grow stem cells from the pancreases of mice

Scientists have succeeded in growing stem cells that have the ability to develop into two different types of cells that make up a healthy pancreas. The research team led by Dr. Hans Clevers of the Hubrecht Institute, The Netherlands, have isolated and grown stem cells from the pancreases of mice using a 3-D culture system previously developed by the scientists.

18 Sep 2013

SignaBlok's novel peptide inhibitor of TREM-1 suppresses cancer progression

SignaBlok, Inc., a Massachusetts-based biopharmaceutical company, today announced the successful in vivo proof of concept data that demonstrate that the company's novel mechanism-based, first-in-class peptide inhibitor of TREM-1 effectively suppresses cancer progression in mouse models of lung cancer and dramatically improves survival in septic mice.

18 Sep 2013

GW researcher awarded NEI grant to study developmental origins of wakefulness in cerebral cortex

Matthew Colonnese, Ph.D., assistant professor of pharmacology and physiology at the George Washington University School of Medicine and Health Sciences, was awarded a $1,973,645 grant from the National Eye Institute to study developmental origins of wakefulness in the cerebral cortex, the region of the brain responsible for cognition and perception.

18 Sep 2013

NHCS researchers discover potential cure for long QT syndrome 2

The National Heart Centre Singapore research team has successfully and completely reversed the effects of the hERG (human ether-a-go-go-related gene) mutation in long QT syndrome 2 in patient-specific heart cells, scoring a world's first.

18 Sep 2013

Study: Mesenchymal stem cell transplantation may help treat stress urinary incontinence

Vaginal delivery presents the possibility of injury for mothers that can lead to "stress urinary incontinence", a condition affecting from four to 35 percent of women who have had babies via vaginal delivery. Many current treatments, such as physiotherapy and surgery, are not very effective.

18 Sep 2013

Researchers develop synthetic peptide that could be a new class of drugs for heart disease

Researchers at the University of Alberta have developed a synthetic peptide that could be the first in a new class of drugs to treat heart disease, high blood pressure and diabetes.

18 Sep 2013

Innovative sodium reduction and fiber ingredients showcased at 20th International Congress of Nutrition

Backed by research that demonstrates significant health benefits as well as unparalleled taste that meets consumer needs, food ingredients are taking center stage as thousands of experts from around the world converge to discuss the state of global health and nutrition at the leading international nutrition conference taking place this week in Spain.

17 Sep 2013

New method to target, eliminate cancer-supporting macrophages in mouse tumors

When a person has cancer, some of the cells in his or her body have changed and are growing uncontrollably. Most cancer drugs try to treat the disease by killing those fast-growing cells, but another approach called immunotherapy tries to stimulate a person's own immune system to attack the cancer itself.

17 Sep 2013

Immune marker predicts transplant success, improves selection of bone marrow donors

The risk of death following bone marrow transplantation can be reduced about 60 percent using a new technique to identify bone marrow donors who make the most potent cancer-fighting immune cells, according to research from St. Jude Children's Research Hospital. The findings appear in the September 16 online issue of the Journal of Clinical Oncology.

17 Sep 2013

Research finding offers new approach to treating melanoma

Scientists at Sanford-Burnham Medical Research Institute today announced the discovery that a gene encoding an enzyme, phosphoinositide-dependent kinase-1, plays an essential role in the development and progression of melanoma. The finding offers a new approach to treating this life-threatening disease.

17 Sep 2013

Flecainide, encainide drugs increase risk of sudden cardiac death

Scientists have discovered that a drug which increases the risk of sudden cardiac death interacts with mistranslated protein-coding genes present in heart muscle.

17 Sep 2013

Researchers develop new variety of corked microbottle for drugs

Sustained-release formulations that release drugs over longer periods of time are not the final step in the evolution of “intelligent” drug delivery systems. Modern pharmaceuticals are being designed to be released only in a specific, diseased organ; on cues from our circadian rhythm; or under specific physiological conditions.

17 Sep 2013

Study reports identification of IDH1 protein as novel biomarker for diagnosis of NSCLC

A protein called isocitrate dehydrogenase is present at high levels in lung cancers and can be detected in the blood, making it a noninvasive diagnostic marker for lung cancers, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

17 Sep 2013

Medical Science News

Neonatal hepatocytes show better thawing recovery than hepatocytes from adult livers

Researchers reveal mechanisms that connect Mfn2 protein to endoplasmic reticulum stress

University of Chicago researchers awarded NIH grant to develop novel multiple sclerosis treatment

Study: Carbonation alters brain's perception of sweetness

Scientists isolate, grow stem cells from the pancreases of mice

SignaBlok's novel peptide inhibitor of TREM-1 suppresses cancer progression

GW researcher awarded NEI grant to study developmental origins of wakefulness in cerebral cortex

NHCS researchers discover potential cure for long QT syndrome 2

Study: Mesenchymal stem cell transplantation may help treat stress urinary incontinence

Researchers develop synthetic peptide that could be a new class of drugs for heart disease

Innovative sodium reduction and fiber ingredients showcased at 20th International Congress of Nutrition

New method to target, eliminate cancer-supporting macrophages in mouse tumors

Immune marker predicts transplant success, improves selection of bone marrow donors

Research finding offers new approach to treating melanoma

Flecainide, encainide drugs increase risk of sudden cardiac death

Researchers develop new variety of corked microbottle for drugs

Study reports identification of IDH1 protein as novel biomarker for diagnosis of NSCLC

Understanding essential role of gut microbes in immune system

microRNA-486 found to be potent tumor-suppressor molecule in lung cancer

Researchers find mucus-regulating protein receptors out of control in uterine, pancreatic cancers

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

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