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IQGAP1 molecule can suppress growth of tumors in the liver

A molecule already implicated in a number of diverse cellular functions can suppress the growth of tumors in the liver, a Mayo Clinic Cancer Center study has found. Its name is IQGAP1, and when the molecule is active in the cells that surround a tumor cell, this "tumor microenvironment" becomes less hospitable to cancer growth. When the molecule is deficient, cancer thrives.

14 Feb 2013

FOXC2 vital to epithelial-mesenchymal transition in breast cancer

Researchers have identified a pivotal protein in a cellular transformation that makes a cancer cell more resistant to treatment and more capable of growing and spreading, making it an inviting new target for drug development.

14 Feb 2013

Researchers identify new way to influence the vital serotonin signaling system

An interdisciplinary team of researchers from the University of Texas Medical Branch at Galveston and the University of Houston has found a new way to influence the vital serotonin signaling system - possibly leading to more effective medications with fewer side effects.

14 Feb 2013

Threat vigilance can protect soldiers against PTSD

The onset of Post-Traumatic Stress Disorder (PTSD) is unpredictable. Because it depends on the unforeseeable occurrence of traumatic events, it is difficult to identify preventative or causative factors. Scientists typically turn to patients who have already developed PTSD to study the disorder, but that means they can't draw comparisons to their psychological state prior to experiencing trauma.

14 Feb 2013

Study finds human MPV as second most common cause of severe bronchiolitis in young children

New Vanderbilt-led research published in the Feb. 14 issue of the New England Journal of Medicine has identified the relatively unknown human metapneumovirus (MPV) as the second most common cause of severe bronchiolitis in young children.

14 Feb 2013

Computer-based cognitive/behavioral training program can benefit patients with fragile X

Researchers at the UC Davis MIND Institute will examine whether children and youth with fragile X syndrome can improve their working memory, cognition and behavior by using an online computer-based cognitive training program, through a new $1 million grant from The John Merck Fund.

14 Feb 2013

Novel approach uses adult stem cells to save sight of diabetes sufferers

Scientists at Queen's University Belfast are hoping to develop a novel approach that could save the sight of millions of diabetes sufferers using adult stem cells.

14 Feb 2013

Link between Jagged-1 protein and bone formation

Researchers from the University of Pennsylvania School of Veterinary Medicine have discovered that a protein called Jagged-1 stimulates human stem cells to differentiate into bone-producing cells.

14 Feb 2013

CELF6 genetic mutation may underlie common behaviors seen in people with autism

Scientists at Washington University School of Medicine in St. Louis have identified a genetic mutation that may underlie common behaviors seen in some people with autism, such as difficulty communicating and resistance to change.

14 Feb 2013

Study demonstrates how CN2097 works to restore neural functions impaired by Angelman syndrome

In a new study in mice, a scientific collaboration centered at Brown University lays out in unprecedented detail a neurological signaling breakdown in Angelman syndrome, a disorder that affects thousands of children each year, characterized by developmental delay, seizures, and other problems.

14 Feb 2013

Mindfulness practitioners gain enhanced control over sensory cortical alpha rhythms

Why does training in mindfulness meditation help patients manage chronic pain and depression? In a newly published neurophysiological review, Brown University scientists propose that mindfulness practitioners gain enhanced control over sensory cortical alpha rhythms that help regulate how the brain processes and filters sensations, including pain, and memories such as depressive cognitions.

14 Feb 2013

New paper advances scientific understanding of glycoproteins’ structure and function

A Simon Fraser University chemist is the lead author on a new paper that advances scientific understanding of the structure and function of glycoproteins, in particular the number and positioning of sugars on them.

14 Feb 2013

Triple-negative breast cancers more biologically diverse than previously believed

Triple-negative breast cancers are more biologically diverse than previously believed and classification should be expanded to reflect this heterogeneity, according to University of North Carolina researchers.

14 Feb 2013

Tousled-like kinases play a key role in suppression and activation of herpesviruses

Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) hide within the worldwide human population. While dormant in the vast majority of those infected, these active herpesviruses can develop into several forms of cancer.

14 Feb 2013

TP PCR methodology may help streamline genetic testing for Huntington's

A new test may help to streamline genetic testing for Huntington Disease (HD) by generating accurate results, avoiding unnecessary additional testing, and improving turnaround time.

14 Feb 2013

Blood’s tendency to clot may contribute to white matter hyperintensities in post-menopausal women

New Mayo Clinic research suggests that blood may hold clues to whether post-menopausal women may be at an increased risk for areas of brain damage that can lead to memory problems and possibly increased risk of stroke. The study shows that blood's tendency to clot may contribute to areas of brain damage called white matter hyperintensities.

14 Feb 2013

CATT study clarifies value of genetic testing for age-related macular degeneration

New findings from a landmark clinical trial show that although certain gene variants may predict whether a person is likely to develop age-related macular degeneration (AMD), a potentially blinding eye disease that afflicts more than nine million Americans, these genes do not predict how patients will respond to Lucentis- and Avastin-, the two medications most widely used to treat the "wet" form of AMD.

13 Feb 2013

Musical training before age 7 creates stronger connections in the brain

If you started piano lessons in grade one, or played the recorder in kindergarten, thank your parents and teachers. Those lessons you dreaded - or loved - helped develop your brain. The younger you started music lessons, the stronger the connections in your brain.

13 Feb 2013

Ability to tune gene activity will permit refined research for drug resistance, cancer

Scientists who built a synthetic gene circuit that allowed for the precise tuning of a gene's expression in yeast have now refined this new research tool to work in human cells, according to research published online in Nature Communications.

13 Feb 2013

Antibody therapeutics targeting GPCRs to be developed by alliance between MorphoSys and Heptares

MorphoSys AG (FSE: MOR; Prime Standard Segment, TecDAX) and UK-based Heptares Therapeutics, the leading GPCR drug discovery and development company, have signed an agreement to discover novel antibody therapeutics targeting G protein-coupled receptors (GPCRs), which are membrane proteins involved in a broad range of biological processes and diseases.

13 Feb 2013

Medical Science News

IQGAP1 molecule can suppress growth of tumors in the liver

FOXC2 vital to epithelial-mesenchymal transition in breast cancer

Researchers identify new way to influence the vital serotonin signaling system

Threat vigilance can protect soldiers against PTSD

Study finds human MPV as second most common cause of severe bronchiolitis in young children

Computer-based cognitive/behavioral training program can benefit patients with fragile X

Novel approach uses adult stem cells to save sight of diabetes sufferers

Link between Jagged-1 protein and bone formation

CELF6 genetic mutation may underlie common behaviors seen in people with autism

Study demonstrates how CN2097 works to restore neural functions impaired by Angelman syndrome

Mindfulness practitioners gain enhanced control over sensory cortical alpha rhythms

New paper advances scientific understanding of glycoproteins’ structure and function

Triple-negative breast cancers more biologically diverse than previously believed

Tousled-like kinases play a key role in suppression and activation of herpesviruses

TP PCR methodology may help streamline genetic testing for Huntington's

Blood’s tendency to clot may contribute to white matter hyperintensities in post-menopausal women

CATT study clarifies value of genetic testing for age-related macular degeneration

Musical training before age 7 creates stronger connections in the brain

Ability to tune gene activity will permit refined research for drug resistance, cancer

Antibody therapeutics targeting GPCRs to be developed by alliance between MorphoSys and Heptares

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