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Inhibition of complement system plays major role in xenograft rejection

Researchers at the Bellvitge Institute of Biomedical Research (IDIBELL) led by Cristina Costa from the New Therapies on Genes and Transplantation group have shown that inhibition of one of the basic components of the complement system protects chondrocytes (cartilage cells) from porcine rejection of xenotransplantation (transplantation between animals of different species).

27 Nov 2013

Researchers show how unusual properties of A3G protein help fight HIV infection

A collaborative team led by a Northeastern University professor may have altered the way we look at drug development for HIV by uncovering some unusual properties of a human protein called APOBEC3G.

27 Nov 2013

Protecting or boosting neurotrophins may slow progression of Huntington's disease

A drug that acts like a growth-promoting protein in the brain reduces degeneration and motor deficits associated with Huntington's disease in two mouse models of the disorder, according to a study appearing November 27 in the Journal of Neuroscience. The findings add to a growing body of evidence that protecting or boosting neurotrophins - the molecules that support the survival and function of nerve cells - may slow the progression of Huntington's disease and other neurodegenerative disorders.

27 Nov 2013

Breakthrough discovery could lead to development of future therapeutics for prostate cancer

Drs. Andrew Goldstein, Owen Witte, and Tanya Stoyanova and their colleagues from UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have found that prostate cancer can develop in one type of stem cell, then evolve to be maintained by a stem cell that looks very different, making prostate cancer stem cells a "moving target" for treatments. The breakthrough discovery connects directly to the development of future therapeutics that target cancer and was published online ahead of print in the Proceedings of the National Academy of Sciences.

27 Nov 2013

African Americans have double the risk of end-stage renal disease compared to white Americans

In the United States, African Americans have approximately twice the risk of end-stage renal disease compared to white Americans, despite a similar prevalence in earlier stages of chronic kidney disease. A large study co-authored by George Washington University researcher Dominic Raj, M.D., identifies factors that mediate differences in the progression of chronic kidney disease between black patients and white patients, as well as among black patients, in order to reduce the excess burden of end-stage renal disease and its complications in black patients.

27 Nov 2013

Freiburg scientists discover substance that suppresses unchecked cell division in leukemia cells

Scientists of the University of Freiburg and the Freiburg University Medical Center from the collaborative research center Medical Epigenetics (SFB 992) have discovered a new active substance that inhibits cell division in leukemia cells and could play an important role in the fight against cancer.

27 Nov 2013

CSHL identifies specific stretch of DNA that helps cancerous blood cells to proliferate in AML

A team of researchers at Cold Spring Harbor Laboratory (CSHL) has identified a leukemia-specific stretch of DNA called an enhancer element that enables cancerous blood cells to proliferate in Acute Myeloid Leukemia (AML), a devastating cancer that is incurable in 70% of patients.

27 Nov 2013

EU-funded project develops new type of vaccine to tackle HIV virus infection

AIDS research has attempted many strategies to tackle the HIV virus infection. Now, a new type of vaccine developed within an EU-funded project, called EuroNeut-41, is based on one of the envelope proteins of the HIV virus, called the gp41 protein. What makes it interesting it that it is directly responsible for the fusion of the HIV virus into human cells. By integrating the gp41 protein into the vaccine, researchers try to trigger the production of antibodies that would block the entrance of HIV into human cells

27 Nov 2013

Research: Human neural stem cells could improve blood flow in critical limb ischemia

New research has shown human neural stem cells could improve blood flow in critical limb ischemia through the growth of new vessels. Critical limb ischemia is a disease that severely obstructs arteries and reduces the blood flow to legs and feet. CLI remains an unmet clinical problem and with an ageing population and the rise in type II diabetes, the incidence of CLI is expected to increase.

27 Nov 2013

UK researchers identify a gene that regulates alcohol consumption

UK researchers have discovered a gene that regulates alcohol consumption and when faulty can cause excessive drinking. They have also identified the mechanism underlying this phenomenon.

26 Nov 2013

Virginia Tech professor named AAAS Fellow for contributions to plant science

John Jelesko, an associate professor of plant pathology, physiology and weed science in the College of Agriculture and Life Sciences at Virginia Tech, has been named a Fellow of the American Association for the Advancement of Science.

26 Nov 2013

Researchers successfully target T lymphocytes which play key role in body's immune response

Researchers at the University of California, San Diego School of Medicine have successfully targeted T lymphocytes - which play a central role in the body's immune response - with another type of white blood cell engineered to synthesize and deliver bits of non-coding RNA or microRNA (miRNA).

26 Nov 2013

Vitamin pills can do more harm than good

Vitamin supplements are a billion-dollar industry. We want to stay healthy and fit and help our bodies with this. But perhaps we are achieving precisely the opposite?

26 Nov 2013

ARMI reveals new insights into how cells organize and form an early mammalian embryo

In research published today in Nature Cell Biology, scientists from the EMBL Australia research team based at Monash University's Australian Regenerative Medicine Institute (ARMI) have revealed new insights into how cells organise and form an early mammalian embryo.

26 Nov 2013

Researchers reveal why some breast cancer cells are resistant to chemotherapy

Researchers at the UNC School of Medicine, working with cell lines in a lab, have discovered why some of the most aggressive and fatal breast cancer cells are resistant to chemotherapy, and UNC scientists are developing ways to overcome such resistance.

26 Nov 2013

Asparagine found in meat, eggs and dairy products is important for normal brain development

Asparagine, found in foods such as meat, eggs, and dairy products, was until now considered non-essential because it is produced naturally by the body. Researchers at the University of Montreal and its affiliated CHU Sainte-Justine Hospital found that the amino acid is essential for normal brain development.

26 Nov 2013

UT Austin study reveals gender differences in sexual regret

In the largest, most in-depth study to date on regret surrounding sexual activity, a team of psychology researchers found a stark contrast in remorse between men and women, potentially shedding light on the evolutionary history of human nature.

26 Nov 2013

Researchers identify progenitor cells that are vital for successful growth of healthy placenta

Dr. Hanna Mikkola and researchers at UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have identified a novel progenitor cell and a related cell communication pathway that are key to the successful growth of a healthy placenta.

26 Nov 2013

Researchers identify new mechanism that causes neurodegeneration

As we age, our body rhythms lose time before they finally stop. Breaking the body clock by genetically disrupting a core clock gene, Bmal1, in mice has long been known to accelerate aging , causing arthritis, hair loss, cataracts, and premature death.

26 Nov 2013

Icahn School of Medicine receives $2.7M to investigate narrow pathway targeted immune therapy

The National Institutes of Health has awarded a research team at the Icahn School of Medicine at Mount Sinai $2.7 million to study systemic treatments for patients with moderate to severe atopic dermatitis (AD), also known as eczema.

26 Nov 2013

Medical Science News

Inhibition of complement system plays major role in xenograft rejection

Researchers show how unusual properties of A3G protein help fight HIV infection

Protecting or boosting neurotrophins may slow progression of Huntington's disease

Breakthrough discovery could lead to development of future therapeutics for prostate cancer

African Americans have double the risk of end-stage renal disease compared to white Americans

Freiburg scientists discover substance that suppresses unchecked cell division in leukemia cells

CSHL identifies specific stretch of DNA that helps cancerous blood cells to proliferate in AML

EU-funded project develops new type of vaccine to tackle HIV virus infection

Research: Human neural stem cells could improve blood flow in critical limb ischemia

UK researchers identify a gene that regulates alcohol consumption

Virginia Tech professor named AAAS Fellow for contributions to plant science

Researchers successfully target T lymphocytes which play key role in body's immune response

Vitamin pills can do more harm than good

ARMI reveals new insights into how cells organize and form an early mammalian embryo

Researchers reveal why some breast cancer cells are resistant to chemotherapy

Asparagine found in meat, eggs and dairy products is important for normal brain development

UT Austin study reveals gender differences in sexual regret

Researchers identify progenitor cells that are vital for successful growth of healthy placenta

Researchers identify new mechanism that causes neurodegeneration

Icahn School of Medicine receives $2.7M to investigate narrow pathway targeted immune therapy

A new method to measure intracellular water in biological systems

Obesity, GLP-1s, and metabolic care

Automation in cell-based workflows

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