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Researchers demonstrate contribution of Immunoglobulin E to atherogenesis

There is an observed correlation between Immunoglobulin E (IgE) levels atherosclerosis, with twice amount of IgE present in patients with acute myocardial infarction as in patients with stable angina or without coronary heart disease (CHD). Guo-Ping Shi, DSc, Jing Wang, MD, PhD, and colleagues in the Department of Medicine at Brigham and Women's Hospital (BWH), have demonstrated the direct participation of IgE in atherogenesis in a mouse model.

10 Aug 2011

First bioengineered anal sphincter for treatment of fecal and urinary incontinence

Researchers have built the first functional anal sphincters in the laboratory, suggesting a potential future treatment for both fecal and urinary incontinence. Made from muscle and nerve cells, the sphincters developed a blood supply and maintained function when implanted in mice.

10 Aug 2011

Flatworms provide new insight into organ regeneration, evolution of mammalian kidneys

Our bodies are perfectly capable of renewing billions of cells every day but fail miserably when it comes to replacing damaged organs such as kidneys. Using the flatworm Schmidtea mediterranea-famous for its capacity to regrow complete animals from minuscule flecks of tissue-as an eloquent example, researchers at the Stowers Institute for Medical Research demonstrated how our distant evolutionary cousins regenerate their excretory systems from scratch.

10 Aug 2011

New genetic cause of retinitis pigmentosa

Combining the expertise of several different labs, University of Iowa researchers have found a new genetic cause of the blinding eye disease retinitis pigmentosa (RP) and, in the process, discovered an entirely new version of the message that codes for the affected protein.

10 Aug 2011

Vitamin D, UVB may help prevent dental caries

Large geographical variations in dental health and tooth loss among U.S. adolescents and young adults have been reported since the mid-1800s. The first study finding a north-south gradient in dental caries was a report of men rejected from the draft for the Civil War for lost teeth, from 8 per 1000 men in Kentucky to 25 in New England.

10 Aug 2011

Moderate exercise may help prevent cognitive decline after bacterial infection

A small amount of exercise shields older animals from memory loss following a bacterial infection, according to a study in the August 10 issue of The Journal of Neuroscience.

10 Aug 2011

Researchers identify molecular pathway behind inflammation, mucus production in asthma

Researchers at the University of Pittsburgh School of Medicine have identified a molecular pathway that helps explain how an enzyme elevated in asthma patients can lead to increased mucus production and inflammation that is characteristic of the lung condition.

9 Aug 2011

NanoString launches nCounter Rat miRNA Expression Assay Kit

NanoString Technologies, Inc., a privately held provider of life science tools for translational research and developer of molecular diagnostics, today announced the availability of the nCounter Rat miRNA Expression Assay Kit for use on its nCounter Analysis System.

From NanoString Technologies 9 Aug 2011

Common culinary spice derivative could treat tendinitis

A derivative of a common culinary spice found in Indian curries could offer a new treatment hope for sufferers of the painful condition tendinitis, an international team of researchers has shown.

9 Aug 2011

New drug to prevent Alzheimer's could be tested on patients within six years

A new drug to prevent the development of Alzheimer's disease could be tested on patients within six years according to researchers at Lancaster University.

9 Aug 2011

MAVS prion-like proteins are involved in innate immunity: Discovery

A person's ability to battle viruses at the cellular level remarkably resembles the way deadly infectious agents called prions misfold and cluster native proteins to cause disease, UT Southwestern Medical Center researchers report.

9 Aug 2011

New study focuses on Anopheles gambiae to prevent spread of malaria

A female mosquito cannot tell if the male that she has mated with is fertile or 'spermless' and unable to fertilise her eggs, according to a new study from scientists at Imperial College London.

9 Aug 2011

Researchers clarify role of two proteins key to T-cell development

In the latest issue of Nature, researchers at the Perelman School of Medicine at the University of Pennsylvania clarify the role of two proteins key to T-cell development.

9 Aug 2011

Engineered T cells can eradicate deadly human ovarian cancer in immune-deficient mice

In a recent issue of Cancer Research, Daniel J. Powell, Jr., PhD, a research assistant professor of Pathology and Laboratory Medicine and Obstetrics and Gynecology at the Perelman School of Medicine at the University of Pennsylvania, showed for the first time that engineered human T cells can eradicate deadly human ovarian cancer in immune-deficient mice.

9 Aug 2011

Los Alamos team sees unprecedented proof of ion's role in enzymatic process

A Los Alamos National Laboratory research team has harnessed neutrons to view for the first time the critical role that an elusive molecule plays in certain biological reactions. The effort could aid in treatment of peptic ulcers or acid reflux disease, or allow for more efficient conversion of woody waste into transportation fuels.

9 Aug 2011

Novel link between two receptors mediates fungal recognition in macrophages

Whitehead Institute researchers have uncovered a novel association between two fungal recognition receptors on the surface of certain immune cells, called macrophages.

9 Aug 2011

Lentiviral vector can kill HIV-infected cells

In what represents an important step toward curing HIV, a USC scientist has created a virus that hunts down HIV-infected cells.

9 Aug 2011

New preclinical approach can guide more efficient drug development for brain-related conditions

The development of drugs for brain-related conditions is not an efficient process; only 8% of candidate drugs that enter clinical trials gain FDA approval. A key reason for this low success rate is a lack of preclinical tests that accurately predict drug efficacy and detect unwanted side effects.

9 Aug 2011

Study shows how certain woodrats put themselves on diet to avoid poisoning

Life is tough for woodrats in deserts of the U.S. Southwest. There are few plants for food, and those plants produce poison to deter rodents, insects and other animals. A new University of Utah study shows how certain woodrats put themselves on a diet to avoid poisoning: They sample a smorgasbord of toxic plants, eat smaller meals, increase time between meals and drink more water if it is available.

9 Aug 2011

Genetically altered spermless ‘mozzies’ to combat malaria

In a fresh new attempt to combat malaria, researchers have developed another way to reduce the numbers of the malaria-spreading blood-suckers: introduce genetically altered spermless males into the population.

8 Aug 2011