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New class of drugs reduces adverse effects of cellular damage from cancer chemotherapy

Chemotherapy kills tumor cells, but it also wreaks havoc on the rest of the body. A team of researchers led by Igor Roninson of the South Carolina College of Pharmacy just reported the discovery of a new class of drugs that reduces the adverse effects of cellular damage from chemotherapy.

8 Aug 2012

TXNIP protein provides best available target for therapies against diabetes, Wolfram syndrome

Inflammation and cell stress play important roles in the death of insulin-secreting cells and are major factors in diabetes. Cell stress also plays a role in Wolfram syndrome, a rare, genetic disorder that afflicts children with many symptoms, including juvenile-onset diabetes.

8 Aug 2012

Applied BioCode receives U.S. patent for ‘Light Transmitted Assay Beads’

Applied BioCode, Inc. today announced that the United Stated Patent and Trademark Office has granted US Patent #8,232,092 "Light Transmitted Assay Beads," describing the method of decoding barcodes and analyzing bioassays using Barcoded Magnetic Beads (BMB) multiplex products.

7 Aug 2012

Schizophrenia may be linked to immune function

New Australian research shows that the brains of people with schizophrenia may be under attack by the immune system, providing the strongest evidence to date of a link between immune function and schizophrenia.

7 Aug 2012

Researchers discover genetic cause of type VII mucopolysaccharidosis in Brazilian Terriers

The genetics research group led by Professor Hannes Lohi, based at the University of Helsinki and the Folkh-lsan Research Center, has, in collaboration with Adjunct Professor Kirsi Sainio's research group, discovered the cause of a life-threatening skeletal disorder affecting Brazilian Terriers. The disease is caused by a mutation in the GUSB gene.

7 Aug 2012

Astrocytes help reduce damaging effects of epilepsy

Epileptic fits are like thunderstorms raging in the brain: Nerve cells excite each other in an uncontrolled way so that strong, rhythmic electrical discharges sweep over whole brain regions. In the wake of such a seizure, the nerve cells are severely affected, and permanent damage is possible. The glia, a class of cells that surround the neurons in the brain, was long suspected to contribute to the damaging effects of epilepsy.

7 Aug 2012

Scientists discover biological marker that may help identify patients’ response to antidepressants

Scientists have discovered a biological marker that may help to identify which depressed patients will respond to an experimental, rapid-acting antidepressant. The brain signal, detectable by noninvasive imaging, also holds clues to the agent's underlying mechanism, which are vital for drug development, say National Institutes of Health researchers.

7 Aug 2012

Geisel professor concerned about steroid abuse by adolescents

Leslie Henderson is concerned about steroid abuse, not necessarily by sports luminaries like Barry Bonds and Mark McGwire, but rather by adolescents.

7 Aug 2012

Blood levels of IL-6 protein may also serve as red flag for relapse in schizophrenia patients

Blood levels of a protein that helps regulate inflammation may also serve as a red flag for relapse in some schizophrenia patients, researchers said.

7 Aug 2012

Researchers identify myostatin as potential therapeutic target for muscular disorders

The study of muscular system protein myostatin has been of great interest to researchers as a potential therapeutic target for people with muscular disorders. Although much is known about how myostatin affects muscle growth, there has been disagreement about what types of muscle cells it acts upon. New research from a team including Carnegie's Chen-Ming Fan and Christoph Lepper narrows down the field to one likely type of cell.

7 Aug 2012

New analysis provides overall genetic fingerprint of various Jewish subpopulations

A new genetic analysis focusing on Jews from North Africa has provided an overall genetic map of the Jewish Diasporas. The findings support the historical record of Middle Eastern Jews settling in North Africa during Classical Antiquity, proselytizing and marrying local populations, and, in the process, forming distinct populations that stayed largely intact for more than 2,000 years.

7 Aug 2012

Commercial cattle vaccine can effectively reduce levels of E. coli by more than 50%

A commercial vaccine for cattle can effectively reduce levels of E. coli by more than 50 percent, a Kansas State University study has found. The vaccine is also effective using two doses instead of the recommended three doses, which can help cut costs for the beef industry.

7 Aug 2012

Study investigates role of inflammation in ALS mouse model

Amyotrophic lateral sclerosis (ALS) is a progressive disease wherein the cells of the central nervous system (CNS) involved in movement and coordination are destroyed. Although the mechanism of ALS is not completely understood, inflammation is believed to play a role in the disease process. A recent study by Howard Weiner and colleagues at Harvard Medical School and Tufts School of Medicine investigated the role of inflammation in a mouse model of ALS.

7 Aug 2012

Scripps Florida scientists to identify and develop new therapeutic approaches against cancers

Scientists from the Florida campus of The Scripps Research Institute have been awarded approximately $1.5 million from the National Institutes of Health to identify and develop new therapeutic approaches against a broad spectrum of cancers.

7 Aug 2012

Studies in mice reveal how mood-altering drugs may affect brain stem cells

Working with mice, Johns Hopkins researchers say they have figured out how stem cells found in a part of the brain responsible for learning, memory and mood regulation decide to remain dormant or create new brain cells. Apparently, the stem cells "listen in" on the chemical communication among nearby neurons to get an idea about what is stressing the system and when they need to act.

7 Aug 2012

Changes in monocytes are biomarker for amyotrophic lateral sclerosis

Researchers from Brigham and Women's Hospital (BWH) are the first to discover that changes in monocytes (a type of white blood cell) are a biomarker for amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease. This finding also brings the medical community a step closer toward a new treatment for the debilitating neurological disease that affects approximately 30,000 Americans.

7 Aug 2012

Fainting appears to have strong genetic predisposition

Fainting has a strong genetic predisposition, according to new research published in the August 7, 2012, print issue of Neurology, the medical journal of the American Academy of Neurology. Fainting, also called vasovagal syncope, is a brief loss of consciousness when your body reacts to certain triggers, such as emotional distress or the sight of blood.

7 Aug 2012

Mutations in Ras gene alone may not cause tumours

Despite a huge amount of research effort, the molecular mechanisms that underlie the transition from a "normal" cell to a cancerous cell are only poorly understood. After the discovery of the first cancer-causing genes or oncogenes and the finding that they are mutated forms of normal cellular genes, it was widely believed that a single mutation was enough to cause cancer.

6 Aug 2012

Human-derived breast cancer xenografts allow revolution in individualized cancer care

Cell cultures are homogeneous. Human tumors are not. A University of Colorado Cancer Center study recently published in the journal Breast Cancer Research and Treatment reports the development of human-derived estrogen-positive (ER+) breast cancer models that retain their heterogeneity, allowing researchers to more accurately test drugs for this disease.

6 Aug 2012

Previously uncharacterized protein dramatically influences inflammation

A UNC-led team of scientists describes the function of a previously uncharacterized protein that dramatically influences inflammation.

6 Aug 2012

Medical Science News

New class of drugs reduces adverse effects of cellular damage from cancer chemotherapy

TXNIP protein provides best available target for therapies against diabetes, Wolfram syndrome

Applied BioCode receives U.S. patent for ‘Light Transmitted Assay Beads’

Schizophrenia may be linked to immune function

Researchers discover genetic cause of type VII mucopolysaccharidosis in Brazilian Terriers

Astrocytes help reduce damaging effects of epilepsy

Scientists discover biological marker that may help identify patients’ response to antidepressants

Geisel professor concerned about steroid abuse by adolescents

Blood levels of IL-6 protein may also serve as red flag for relapse in schizophrenia patients

Researchers identify myostatin as potential therapeutic target for muscular disorders

New analysis provides overall genetic fingerprint of various Jewish subpopulations

Commercial cattle vaccine can effectively reduce levels of E. coli by more than 50%

Study investigates role of inflammation in ALS mouse model

Scripps Florida scientists to identify and develop new therapeutic approaches against cancers

Studies in mice reveal how mood-altering drugs may affect brain stem cells

Changes in monocytes are biomarker for amyotrophic lateral sclerosis

Fainting appears to have strong genetic predisposition

Mutations in Ras gene alone may not cause tumours

Human-derived breast cancer xenografts allow revolution in individualized cancer care

Previously uncharacterized protein dramatically influences inflammation

Leveraging the Radian ASAP in standard casework

A journey through science, software, and innovation: Insights from the Bruker software team

CellVoyant's AI-Powered Vision for the Future of Cell Therapy

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