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Researchers identify how telomerase is recruited to chromosome ends

Stem cells are special. Nestled in muscle and skin, organ and bone, they bide their time over years or decades until called to replace damaged or lost tissue. One secret to their longevity is an enzyme called telomerase, which stills the relentless ticking of the molecular clock that limits the life span of other cells.

3 Aug 2012

Researchers discover surprising and unexpected plasticity in the embryonic endothelium

UCLA stem cell researchers have found for the first time a surprising and unexpected plasticity in the embryonic endothelium, the place where blood stem cells are made in early development.

3 Aug 2012

Researchers uncover 9 new genes associated with bone health

Researchers have uncovered 9 new genes associated with bone health. This collaborative study found clues to the cause of bone disorders such as osteoporosis, osteogenesis imperfecta, and high bone density syndromes by investigating the bone mineral content, strength and flexibility.

3 Aug 2012

Rodent study shows potential for development of more virulent malaria if 'leaky' vaccine used

Using a rodent model to examine the long-term effects of a potential malaria vaccine, a new study published in PLoS Biology by researchers at Penn State University shows that the vaccine could lead to the development of more virulent forms of malaria, the PLoS blog "Biologue" reports.

3 Aug 2012

Affymetrix announces availability of SensationPlus FFPE Amplification and 3' IVT Labeling Kit

Affymetrix, Inc. announced today the availability of SensationPlus FFPE Amplification and 3' IVT Labeling Kit (SensationPlus FFPE Reagent Kit), consisting of RNA amplification and labeling modules, to enable gene expression profiling of formalin-fixed, paraffin-embedded (FFPE) samples on GeneChip 3' IVT arrays and Almac XcelTM Array for disease clinical research and retrospective studies.

3 Aug 2012

SAGE Labs, Autism Speaks expand partnership to create first rat models for translational research

Autism Speaks, the world's leading autism science and advocacy organization, today announced its expanded collaboration with Sigma Advanced Genetic Engineering (SAGE) Labs, an initiative of Sigma- Life, to develop the first rat models with modified autism associated genes, intended to accelerate discovery and translational autism research.

3 Aug 2012

Myc-directed repression of tristetraprolin important for development and maintenance of cancer

Scientists from the Florida campus of The Scripps Research Institute have identified a protein that impairs the development and maintenance of lymphoma (cancer of the lymph nodes), but is repressed during the initial stages of the disease, allowing for rapid tumor growth.

3 Aug 2012

Fatty acid synthase provides new target for treatment of obesity and diabetes

Researchers at Washington University School of Medicine in St. Louis have identified a potential target for treating diabetes and obesity.

3 Aug 2012

New method could increase number of genetic components in synthetic biologists' toolkit

Through the assembly of genetic components into "circuits" that perform logical operations in living cells, synthetic biologists aim to artificially empower cells to solve critical problems in medicine, energy and the environment. To succeed, however, they'll need far more reliable genetic components than the small number of "off-the-shelf" bacterial parts now available.

3 Aug 2012

Australian scientists discover new virus in bats

Australian scientists have discovered a new virus in bats that could help shed light on how Hendra and Nipah viruses cause disease and death in animals and humans. The new virus - named 'Cedar' after the Queensland location where it was discovered - is a close relative of the deadly Hendra and Nipah viruses.

3 Aug 2012

Scientists link some cases of Essential Tremor to specific genetic problem

Researchers at the University of Montreal and its affiliated CHU Sainte-Justine and CHUM hospitals have linked some cases of Essential Tremor (ET) to a specific genetic problem. ET is the most common movement disorder, becoming increasingly frequent with increasing age, which is characterized by an involuntary shaking movement (tremor) that occurs with motion, particularly when doing precise fine movement.

3 Aug 2012

New insight into why glioblastoma multiforme recurs in adults

A study by UT Southwestern Medical Center researchers published online today in Nature reveals new insight into why the most common, deadly kind of brain tumor in adults recurs and identifies a potential target for future therapies.

2 Aug 2012

Adult human brain remarkably malleable and capable of new feats

There is growing evidence that, beyond what was previously believed, the adult human brain is remarkably malleable and capable of new feats -- even in the last decades of life.

2 Aug 2012

Starvation drives methamphetamine-related death in fruit flies

A new study finds that fruit flies exposed to methamphetamine drastically reduce their food intake and increase their physical activity, just as humans do. The study, which tracked metabolic and behavioral changes in fruit flies on meth, indicates that starvation is a primary driver of methamphetamine-related death in the insects.

2 Aug 2012

B-cell substances may play a role in MS progression

Wayne State University School of Medicine researchers, working with colleagues in Canada, have found that one or more substances produced by a type of immune cell in people with multiple sclerosis (MS) may play a role in the disease's progression. The finding could lead to new targeted therapies for MS treatment.

2 Aug 2012

Possible molecular link between circadian rhythm disturbances and increased inflammatory response

Scientists have known for some time that throwing off the body's circadian rhythm can negatively affect body chemistry. In fact, workers whose sleep-wake cycles are disrupted by night shifts are more susceptible to chronic inflammatory diseases such as diabetes, obesity and cancer.

2 Aug 2012

Scientists discover critical molecular switch that regulates autophagy

The body has a built-in system known as autophagy, or 'self-eating,' that controls how cells live or die. Deregulation of autophagy is linked to the development of human diseases, including neural degeneration and cancer.

2 Aug 2012

Three papers focus on nucleosomes and may help uncover the rules governing gene transcription

A trio of groundbreaking publications from researchers in Northwestern University's Physical Sciences-Oncology Center (PS-OC) report important methodological advances that will enable a better understanding of how gene expression is regulated, both in normal cells and in cancer cells. This knowledge could lead to the development of more effective therapeutic agents to treat cancer patients.

2 Aug 2012

'Global brain connectivity' explains 10% of variance in individual intelligence

When it comes to intelligence, what factors distinguish the brains of the exceptionally smart from those of average humans? As science has long suspected, overall brain size matters somewhat, accounting for about 6.7 percent of individual variation in intelligence. More recent research has pinpointed the brain's lateral prefrontal cortex, a region just behind the temple, as a critical hub for high-level mental processing, with activity levels there predicting another 5 percent of variation in individual intelligence.

2 Aug 2012

Researchers discover genetic process that can restore function to a CF defective protein

Researchers at the University of Iowa Carver College of Medicine have discovered a genetic process that can restore function to a defective protein, which is the most common cause of cystic fibrosis (CF).

2 Aug 2012

Medical Science News

Researchers identify how telomerase is recruited to chromosome ends

Researchers discover surprising and unexpected plasticity in the embryonic endothelium

Researchers uncover 9 new genes associated with bone health

Rodent study shows potential for development of more virulent malaria if 'leaky' vaccine used

Affymetrix announces availability of SensationPlus FFPE Amplification and 3' IVT Labeling Kit

SAGE Labs, Autism Speaks expand partnership to create first rat models for translational research

Myc-directed repression of tristetraprolin important for development and maintenance of cancer

Fatty acid synthase provides new target for treatment of obesity and diabetes

New method could increase number of genetic components in synthetic biologists' toolkit

Australian scientists discover new virus in bats

Scientists link some cases of Essential Tremor to specific genetic problem

New insight into why glioblastoma multiforme recurs in adults

Adult human brain remarkably malleable and capable of new feats

Starvation drives methamphetamine-related death in fruit flies

B-cell substances may play a role in MS progression

Possible molecular link between circadian rhythm disturbances and increased inflammatory response

Scientists discover critical molecular switch that regulates autophagy

Three papers focus on nucleosomes and may help uncover the rules governing gene transcription

'Global brain connectivity' explains 10% of variance in individual intelligence

Researchers discover genetic process that can restore function to a CF defective protein

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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