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New small molecule drug targets active state of cancer-causing KRAS mutant

A new small molecule drug helps to bind the naturally occurring cellular chaperone cyclophilin A (CYPA) to the active state of the cancer-causing mutant KRASG12C, disrupting oncogenic signaling and tumor growth in several models of human cancer.

17 Aug 2023

Study explores the use of collective intelligence to improve medical diagnosis

A recent study revealed the possibility of combining knowledge representation models and collective intelligence for medical diagnosis.

17 Aug 2023

Is shift work associated with depression and anxiety, and if so, does lifestyle mediate the associations?

Researchers discuss the contribution of lifestyle factors in depression and anxiety among shift workers

17 Aug 2023

New study offers preliminary estimates of mortality risk by stage in Alzheimer's disease

Researchers examine the expected survival of people at each stage of Alzheimer's disease.

17 Aug 2023

Study suggests antibodies triggered by COVID-19 mRNA vaccination may depend on prior infection history

Researchers evaluated distinct immune responses to mRNA and vector-based COVID-19 vaccines and natural SARS-CoV-2 infections.

17 Aug 2023

Interactomics-based analysis suggests that rhinitis and rhinitis with asthma are mechanistically different diseases

Researchers used human transcriptomic data to differentiate the molecular mechanisms associated with two phenotypes of allergic rhinitis: rhinitis and rhinitis with asthma.

17 Aug 2023

Can machine learning algorithms identify patients at risk of a delay in starting cancer treatment?

Multi-level machine learning models for estimating the risk of delay between cancer diagnosis and treatment initiation in a large group of cancer patients.

17 Aug 2023

Potential of COVID-19 convalescent plasma for future monoclonal antibodies against severe SARS-CoV-2 inflammation

Researchers report that convalescent plasma treatment is most effective in treating hospitalized COVID-19 patients.

17 Aug 2023

Long-term use of proton pump inhibitors associated with increased risk of dementia

Researchers determine whether the current and cumulative use of prescription proton pump inhibitors increases the risk of incident dementia.

17 Aug 2023

Brief nurse-delivered sleep restriction therapy in primary care is clinically effective for insomnia disorder, safe, and likely to be cost-effective

Researchers compare the cost-effectiveness and clinical impact of nurse-delivered sleep restriction therapy with sleep hygiene for insomnia treatment.

17 Aug 2023

Mitochondrial dysfunction may be a contributor to schizophrenia

Researchers at Rutgers and Emory University are gaining insights into how schizophrenia develops by studying the strongest-known genetic risk factor.

16 Aug 2023

Study sheds light on how cold temperatures affect appetite

Neuroscientists at Scripps Research have identified brain circuits that make mammals want to eat more when they are exposed to cold temperatures.

16 Aug 2023

Injection of a specific blood factor can replicate the benefits of exercise in the brain

Pre-clinical trials by University of Queensland researchers have found an injection of a specific blood factor can replicate the benefits of exercise in the brain.

16 Aug 2023

Long DNA molecules reveal new scar types in HR-deficient cancers

DNA can be damaged by toxins, radiation, or even normal cell division, but human cells must continually fix DNA breaks to survive.

16 Aug 2023

Sulfate groups on complex sugar molecules affect brain plasticity

Can you recognize someone you haven't seen in years, but forget what you had for breakfast yesterday? Our brains constantly rearrange their circuitry to remember familiar faces or learn new skills, but the molecular basis of this process isn't well understood.

16 Aug 2023

Medical Science News

New small molecule drug targets active state of cancer-causing KRAS mutant

Study explores the use of collective intelligence to improve medical diagnosis

Is shift work associated with depression and anxiety, and if so, does lifestyle mediate the associations?

New study offers preliminary estimates of mortality risk by stage in Alzheimer's disease

Study suggests antibodies triggered by COVID-19 mRNA vaccination may depend on prior infection history

Interactomics-based analysis suggests that rhinitis and rhinitis with asthma are mechanistically different diseases

Can machine learning algorithms identify patients at risk of a delay in starting cancer treatment?

Potential of COVID-19 convalescent plasma for future monoclonal antibodies against severe SARS-CoV-2 inflammation

Long-term use of proton pump inhibitors associated with increased risk of dementia

Brief nurse-delivered sleep restriction therapy in primary care is clinically effective for insomnia disorder, safe, and likely to be cost-effective

Mitochondrial dysfunction may be a contributor to schizophrenia

Study sheds light on how cold temperatures affect appetite

Injection of a specific blood factor can replicate the benefits of exercise in the brain

Long DNA molecules reveal new scar types in HR-deficient cancers

Sulfate groups on complex sugar molecules affect brain plasticity

Bioengineered nanovesicles could improve cancer treatment

Next-generation sequencing provides novel insights into the mechanisms underlying autism and myotonic muscular dystrophy

Research shows how mosquito-transmitted viruses hijack host cells to promote infection

The gut microbiome of critically ill individuals and its modification by immunonutrition and probiotics

New method uses AI to augment spatial transcriptomics technologies

Fourier 80: bringing benchtop NMR systems to the laboratory

How industrial hygiene flow calibration supports defensible exposure data

How electrical engineering ensures accurate calibration and patient safety

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