Molecular & Structural Biology

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New label-free microscopic techniques provide better visualization of extracellular vesicles

The Biophotonics Imaging Lab at the Beckman Institute for Advanced Science and Technology has developed imaging techniques that investigate tissues without using any staining or labels.

21 Feb 2020

Study shows what drives an ordered row of alternating peptides

A team of researchers has verified that it is possible to engineer two-layered nanofibers consisting of an ordered row of alternating peptides, and has also determined what makes these peptides automatically assemble into this pattern.

20 Feb 2020

Researchers map the cellular diversity of entire salivary gland tumors

What goes on inside and between individual cells during the very earliest stages of tumor development? Single cell sequencing technologies and a mouse model have enabled researchers to comprehensively map the cellular diversity of whole salivary gland tumors and trace the path of cancer stem cells.

20 Feb 2020

Plant-based relatives of cholesterol could boost gene-infused nanoparticle delivery

Gene-infused nanoparticles used for combating disease work better when they include plant-based relatives of cholesterol because their shape and structure help the genes get where they need to be inside cells.

20 Feb 2020

Scientists discover novel molecular pathway involved in immunotherapy response

Scientists at The Wistar Institute discovered a novel pathway that enables detection of DNA in the cytoplasm and triggers inflammation and cellular senescence.

20 Feb 2020

Researchers identify protein that maintains balance between protrusive and contractile machineries

Tropomodulin maintains the fine balance between the protein machineries responsible for cell movement and morphogenesis.

18 Feb 2020

Live-cell imaging provides new insights into dynamic structure of mitochondria

As power plants and energy stores, mitochondria are essential components of almost all cells in plants, fungi and animals. Until now, it has been assumed that these functions underlie a static structure of mitochondrial membranes.

18 Feb 2020

Researchers uncover genetic mechanisms that govern brain plasticity

Genetic mechanisms that govern brain plasticity - the brain's ability to change and adapt - have been uncovered by researchers at the University of Birmingham.

18 Feb 2020

Bruker announces fully validated NMR module for metabolite quantification in urine (research use only)

Bruker has announced the release of the B.I.QUANT-UR™ 1.1 module, which complies with DIN-ISO criteria for the quantification of urine metabolites by NMR.

From Bruker BioSpin - NMR, EPR and Imaging 18 Feb 2020

Researchers map key atomic structures in measles, mumps, flu and RSV

Northwestern University researchers have, for the first time, determined the 3D atomic structure of a key complex in paramyxoviruses, a family of viruses that includes measles, mumps, human parainfluenza and respiratory syncytial virus.

17 Feb 2020

Detailed maps of breast cancer reveal how genetic changes shape the tumor landscape

Scientists have created one of the most detailed maps of breast cancer ever achieved, revealing how genetic changes shape the physical tumor landscape, according to research funded by Cancer Research UK and published in Nature Cancer today (Monday).

17 Feb 2020

New molecular 'fishing' technology can find individual molecules in blood

Like finding a needle in a haystack, Liviu Movileanu can find a single molecule in blood. Movileanu, professor at Syracuse University, and recently graduated Ph.D. student Avinash Thakur will present their research on Monday, February 17 at the 64th Annual Meeting of the Biophysical Society in San Diego, California.

16 Feb 2020

New technique can label diverse molecules in a single tissue sample

A new technique can label diverse molecules and amplify the signal to help researchers spot those that are especially rare. Called SABER (signal amplification by exchange reaction), Peng Yin's lab at Harvard's Wyss Institute first introduced this method last year and since have found ways to apply it to proteins, DNA and RNA.

16 Feb 2020

Pioneering technique reveals structure of Parkinson's disease protein in action

The top contributor to familial Parkinson's disease is mutations in leucine-rich repeat kinase 2 (LRRK2), whose large and difficult structure has finally been solved, paving the way for targeted therapies.

16 Feb 2020

New biological tool can detect and debug faulty genetic circuits

Every cell in our body has a computer-like control system that sends biological signals through thousands of circuits to monitor the cell's needs and regulate its responses.

16 Feb 2020

Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain

Crotoxin, extracted from the venom of the South American rattlesnake Crotalus durissus terrificus, has been studied for almost a century for its analgesic, anti-inflammatory and antitumor activities and as an even more powerful muscle paralyzer than botulinum toxin.

16 Feb 2020

Research reveals new pathogenic mechanism for influenza NS1 protein

Influenza is a deadly virus, with about 290,000 to 650,000 deaths worldwide each year. When pandemics hit, the toll can soar: The Spanish flu of 1918 caused 40 million to 50 million deaths, the Asian flu of 1957 caused 2 million deaths, and the Hong Kong flu of 1968 caused 1 million deaths.

16 Feb 2020

Molecular & Structural Biology

New label-free microscopic techniques provide better visualization of extracellular vesicles

Study shows what drives an ordered row of alternating peptides

Researchers map the cellular diversity of entire salivary gland tumors

Plant-based relatives of cholesterol could boost gene-infused nanoparticle delivery

Scientists discover novel molecular pathway involved in immunotherapy response

Researchers identify protein that maintains balance between protrusive and contractile machineries

Live-cell imaging provides new insights into dynamic structure of mitochondria

Researchers uncover genetic mechanisms that govern brain plasticity

Bruker announces fully validated NMR module for metabolite quantification in urine (research use only)

Researchers map key atomic structures in measles, mumps, flu and RSV

Detailed maps of breast cancer reveal how genetic changes shape the tumor landscape

New molecular 'fishing' technology can find individual molecules in blood

New technique can label diverse molecules in a single tissue sample

Pioneering technique reveals structure of Parkinson's disease protein in action

New biological tool can detect and debug faulty genetic circuits

Novel formulation allows use of toxin from rattlesnake venom to control neuropathic pain

Research reveals new pathogenic mechanism for influenza NS1 protein

Researchers identify key modifier in large genetic deletion linked to neurodevelopmental disorders

New method for real-time detection of neural oscillation bursts

Study: Survival rates have improved after kidney transplantation during childhood

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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