Molecular & Structural Biology

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Two small molecule inhibitors can help improve precision, efficiency of CRISPR-Cas9 gene editing

A new study published in Nature Communications demonstrates how small molecule inhibitors can be used to improve the precision and efficiency of CRISPR-Cas9 gene editing.

25 Aug 2023

The outcome of invasive S. pyogenes infection is regulated by an interplay between human STING genotype and bacterial NADase activity

The interplay between human STING genotype and bacterial NADase activity.

22 Aug 2023

Study sheds light on how SARS-CoV-2 virus switches between replication and packaging

Immediately after the infection of a cell in the throat or lungs, the SARS-CoV-2 virus works very hard to replicate, using the human cell's metabolic pathways to produce its proteins and make sure that its genetic material (the RNA genome) is copied.

21 Aug 2023

Glycans and GBPs: How their interplay shapes immunity in infection and autoimmune diseases

Researchers discuss the regulatory roles of glycans and glycan-binding proteins in modulating immune responses.

21 Aug 2023

Exploring developmental pathways and disease interactions in nervous and stomatognathic systems

Scientists discuss the intricate relationship between the nervous and stomatognathic systems.

21 Aug 2023

Beneficial gut bacteria use mucus lining to stay in place, study finds

When it comes to gut health, it doesn't just matter who's invited to the party, but how they behave.

18 Aug 2023

Regulation of cytotoxic T-cell differentiation and exhaustion by mTOR signaling

Researchers describe molecular signalling regulated by mTOR among memory and exhausted cytotoxic CD8+ T lymphocytes.

18 Aug 2023

The interplay between immunity, the nervous system, and microbiota

Researchers review the influence of the gut microbiota on neural and immune network

15 Aug 2023

A computational model identifies metabolites associated with Parkinson's disease

Researchers identify significant metabolites involved in the development and progression of Parkinson’s disease.

15 Aug 2023

Epigenetic drug-sensitive biomarkers for cancer

Researchers perform an epigenome-wide multi-omic high-throughput screen to identify actionable epigenetic drug-sensitive biomarkers.

15 Aug 2023

The role of self-extracellular nucleic acids in neuroinflammation

Researchers explore the role of self-extracellular nucleic acids in diseases like stroke, multiple sclerosis, Alzheimer’s disease, and Parkinson’s disease.

14 Aug 2023

Exploring molecular mechanisms and genetic dysregulation in aging and age-associated diseases

Researchers review existing data on the molecular basis of senescence and neurodegeneration in age-related brain diseases.

10 Aug 2023

NLRP3 inflammasome plays a role in podocyte aging

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, entitled, "Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span."

8 Aug 2023

Mitochondrial protein structure activates cell's integrated stress response

Often referred to as the "powerhouses of the cell," mitochondria are well known for their role as energy suppliers, but these organelles are also critical for maintaining our overall health.

8 Aug 2023

Unexpected link between pure mathematics and genetics discovered

An interdisciplinary team of mathematicians, engineers, physicists, and medical scientists have uncovered an unexpected link between pure mathematics and genetics, that reveals key insights into the structure of neutral mutations and the evolution of organisms.

8 Aug 2023

Molecular & Structural Biology

Two small molecule inhibitors can help improve precision, efficiency of CRISPR-Cas9 gene editing

The outcome of invasive S. pyogenes infection is regulated by an interplay between human STING genotype and bacterial NADase activity

Study sheds light on how SARS-CoV-2 virus switches between replication and packaging

Glycans and GBPs: How their interplay shapes immunity in infection and autoimmune diseases

Exploring developmental pathways and disease interactions in nervous and stomatognathic systems

Beneficial gut bacteria use mucus lining to stay in place, study finds

Regulation of cytotoxic T-cell differentiation and exhaustion by mTOR signaling

The interplay between immunity, the nervous system, and microbiota

A computational model identifies metabolites associated with Parkinson's disease

Epigenetic drug-sensitive biomarkers for cancer

The role of self-extracellular nucleic acids in neuroinflammation

Exploring molecular mechanisms and genetic dysregulation in aging and age-associated diseases

NLRP3 inflammasome plays a role in podocyte aging

Mitochondrial protein structure activates cell's integrated stress response

Unexpected link between pure mathematics and genetics discovered

Understanding variations in SARS-CoV-2 evolution and clearance by immunodeficiency status

Role of M2 macrophage-derived exosomes in controlling neutrophil-mediated tissue injury in sepsis

Deep learning improves protein design by 10x

Cryo-EM structures and functions of potent bispecific antibodies against multiple Omicron sublineages

Scientists develop breakthrough technology for detecting protein modifications

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

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