Molecular & Structural Biology

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Structure of protein methyltransferase from the monkeypox virus deciphered

Scientists from the Institute of Organic Chemistry and Biochemistry in Prague have deciphered the structure of the protein methyltransferase from the monkeypox virus

30 Apr 2023

Cryogenic electron microscopy helps visualize structural details of gene regulation process

LMU researchers show detailed displacement process of TBP transcription factor from DNA by Mot1 enzyme.

28 Apr 2023

Researchers develop novel bio-inspired molecules to enhance bone regeneration

People's ability to regenerate bones declines with age and is further decreased by diseases such as osteoporosis.

28 Apr 2023

Study uncovers a universal molecular-level explanation for biological homeostasis and adaptation

Landmark research published in Nature Communications by mathematicians Dr Robyn Araujo at QUT and Professor Lance Liotta of George Mason University in the US sets out the definitive picture of biological adaptation at the level of intermolecular interactions.

28 Apr 2023

Study findings could be harnessed to engineer new botulinum neurotoxin E variants

A team of researchers from the University of California, Irvine, have revealed the first crystal structures of the receptor-binding domain of botulinum neurotoxin E (BoNT/E) in complex with its human neuronal receptors, synaptic vesicle glycoprotein 2A (SV2A).

27 Apr 2023

New strategy for identifying small molecules offers a promising path for discovering targeted drugs

Scripps Research scientists have developed a new strategy for identifying small molecules that can change the function of proteins, offering a promising path for discovering targeted drugs.

27 Apr 2023

Study uncovers new clues and raises more questions about CRISPR

CRISPR claimed scientific fame for its ability to quickly and accurately edit genes. But, at the core, CRISPR systems are immune systems that help bacteria protect themselves from viruses by targeting and destroying viral DNA and RNA.

27 Apr 2023

Study reveals the mechanism behind oligomeric assembly of a BAR-domain-containing protein

Cell membranes play a critical role by serving as containment units and separating the inner cellular space from the extracellular environment.

26 Apr 2023

Researchers unravel processes that direct the development of astrocyte structure

Researchers at Baylor College of Medicine have unraveled the processes that give astrocytes, the most abundant glial cell in the brain, their special bushy shape, which is fundamental for brain function.

26 Apr 2023

Study reveals ERK signaling as a crucial molecular switch between scarring and regeneration

Why do some animals regenerate lost tissues after injury while others don't? Researchers from the lab of Kerstin Bartscherer (Osnabrück University and formerly Hubrecht Institute) and Ashley Seifert (University of Kentucky) studied spiny mice, which have a remarkable regenerative capacity, to answer this question.

26 Apr 2023

Study explores how evolution has influenced the brain architecture

The connections between the structure of the brain and its function are a key focus of neuroscience. A new Medical University of Vienna study involving a team of international partners has been looking at evolution and its relationship with the capabilities of human and animal brain architecture.

26 Apr 2023

Neutrophils found to play a key role in fibromyalgia pain

Targeting neutrophil activity and interactions with sensory neurons may be a potential approach for treating fibromyalgia pain.

25 Apr 2023

Revolutionizing protein design: AI generates novel sequences

Researchers present two deep-learning models that can predict amino acid sequences and 3D protein structures based on secondary-structure design objectives. These models offer de novo design capacity and can discover new protein sequences beyond known proteins.

25 Apr 2023

Researchers pioneer a new method for fast miRNA amplification and detection

In the early 1990s, scientists who were studying the development of a roundworm identified a small RNA molecule that regulated the expression of specific genes.

24 Apr 2023

RExMap unlocks gut microbiome secrets: Revealing their global influence on health

Groundbreaking RExMap database enables species-level mapping of gut microbes, revealing a core set of fifteen microbes shared by humans across the globe.

21 Apr 2023

Research reveals how a bacterial pathogen creates syringe-like structures to infect the intestines

Researchers at UT Southwestern Medical Center have discovered how a bacterium that infects people after they eat raw or undercooked shellfish creates syringe-like structures to inject its toxins into intestinal cells.

20 Apr 2023

Protein OCLN found to play crucial role in SARS-CoV-2 cell-to-cell transmission

Research explains how the SARS-CoV-2 virus spreads efficiently by directly infecting neighboring cells through a process called cell-to-cell transmission. The virus uses a protein called occludin (OCLN) to enter the cells and causes syncytium formation, which leads to viral spread.

20 Apr 2023

Molecular & Structural Biology

Structure of protein methyltransferase from the monkeypox virus deciphered

Cryogenic electron microscopy helps visualize structural details of gene regulation process

Researchers develop novel bio-inspired molecules to enhance bone regeneration

Study uncovers a universal molecular-level explanation for biological homeostasis and adaptation

Study findings could be harnessed to engineer new botulinum neurotoxin E variants

New strategy for identifying small molecules offers a promising path for discovering targeted drugs

Study uncovers new clues and raises more questions about CRISPR

Study reveals the mechanism behind oligomeric assembly of a BAR-domain-containing protein

Researchers unravel processes that direct the development of astrocyte structure

Study reveals ERK signaling as a crucial molecular switch between scarring and regeneration

Study explores how evolution has influenced the brain architecture

Neutrophils found to play a key role in fibromyalgia pain

Revolutionizing protein design: AI generates novel sequences

Researchers pioneer a new method for fast miRNA amplification and detection

RExMap unlocks gut microbiome secrets: Revealing their global influence on health

Research reveals how a bacterial pathogen creates syringe-like structures to infect the intestines

Protein OCLN found to play crucial role in SARS-CoV-2 cell-to-cell transmission

Researchers develop novel molecular nanocages for siRNA delivery

Study reveals a previously unknown mechanism for DNA folding

New drug could effectively disarm multidrug-resistant bacteria

Reimagining light scattering for biotherapeutics

Empowering genomics research with cloud-based innovation

Quality, Patient Safety and Innovation Manager at Elsevier

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