Molecular & Structural Biology

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Breathing and tilting motions of influenza glycoproteins could be exploited to better defend against flu

The potential "tripledemic" of influenza, SARS-CoV-2 and RSV (respiratory syncytial virus) infection continues to be a concern.

25 Jan 2023

Cryo-electron microscopy reveals detailed blueprint of viral genome replication machinery

RNA viruses, such as the coronavirus that causes COVID-19, are in a life-and-death race the moment they infect a cell.

25 Jan 2023

Targeting newly discovered signaling pathway could boost the potency of cancer therapeutics

Cells zealously protect the integrity of their genomes, because damage can lead to cancer or cell death. The genome - a cell's complete set of DNA - is most vulnerable while it is being duplicated before a cell divides. Cancer cells constantly are dividing, so their genomes are constantly in jeopardy.

24 Jan 2023

Neurons in a bow-shaped brain region become hyperactive after chronic stress exposure

It's clear that chronic stress can impact our behavior, leading to problems like depression, reduced interest in things that previously brought us pleasure, even PTSD.

24 Jan 2023

Study: 12-hour gene expression rhythms are missing or altered in schizophrenic brains

Researchers at the University of Pittsburgh School of Medicine, U.S. present the first evidence of 12-hour cycles of gene activity in the human brain. Publishing in the open access journal PLOS Biology on January 24th, the study led by Madeline R. Scott also reveals that some of those 12-hour rhythms are missing or altered in the postmortem brains of patients with schizophrenia.

24 Jan 2023

Study uncovers protein that acts as a brake for DNA replication

A protein that prepares DNA for replication also prevents the replication process from running out of control, according to a new study by Weill Cornell Medicine researchers.

24 Jan 2023

Novel amyloid protein discovered from canine mammary tumors

A collaboration led by scientists at Tokyo University of Agriculture and Technology (TUAT), Japan, has discovered a novel amyloid protein from canine mammary tumors.

24 Jan 2023

Cryo-electron microscopy captures the first 3D structure of SPOP protein that drives cancer

SPOP is the most mutated protein in prostate cancer and plays a role in endometrial, uterine and other cancers. Despite this importance, how SPOP mutations drive cancer has been incompletely understood.

23 Jan 2023

New tool can accurately discover, quantify RNA molecules from error-prone long-read RNA sequencing data

On the journey from gene to protein, a nascent RNA molecule can be cut and joined, or spliced, in different ways before being translated into a protein.

20 Jan 2023

Study reveals the mechanism through which Sirtuin 7 protein suppresses thermogenesis in mice

Mammals convert the energy stored in adipose (fat) tissue into heat via a process known as thermogenesis.

20 Jan 2023

First-ever computer reconstruction replicates the exact chemical and 3D structure of a 'live' virus

An Aston University researcher has created the first ever computer reconstruction of a virus, including its complete native genome.

20 Jan 2023

New drug target for Ewing sarcoma discovered

Scientists at Cold Spring Harbor Laboratory (CSHL) have discovered a new drug target for Ewing sarcoma, a rare kind of cancer usually diagnosed in children and young adults.

20 Jan 2023

HKUST researchers map out the fundamental mechanisms of C.elegans Microprocessor

The study of microRNAs (miRNAs), small RNAs that play important roles in gene regulation in animals and humans alike, have long been a topic of interest to many.

19 Jan 2023

Research provides a comprehensive structural framework to design safer pain-relieving drugs

In the continuing effort to improve upon opioid pain relievers, American and Chinese scientists used cryoEM technology to solve the detailed structures of the entire family of opioid receptors bound to their naturally occurring peptides.

18 Jan 2023

Study explores the role of endocannabinoids in hazardous drinking among young adults

Although heavy drinking in young adulthood increases the risk for alcohol use disorder (AUD), not all young heavy drinkers go on to develop AUD, globally the most common substance use disorder.

18 Jan 2023

New Pyk2-derived peptide inhibits breast cancer metastasis

An estimated ninety percent of deaths from breast cancer are due to complications resulting from metastasis, a process in which cancer cells break away from where they first formed, travel through the blood or lymph circulatory system, and form new, metastatic tumors in other parts of the body.

17 Jan 2023

Molecular & Structural Biology

Breathing and tilting motions of influenza glycoproteins could be exploited to better defend against flu

Cryo-electron microscopy reveals detailed blueprint of viral genome replication machinery

Targeting newly discovered signaling pathway could boost the potency of cancer therapeutics

Neurons in a bow-shaped brain region become hyperactive after chronic stress exposure

Study: 12-hour gene expression rhythms are missing or altered in schizophrenic brains

Study uncovers protein that acts as a brake for DNA replication

Novel amyloid protein discovered from canine mammary tumors

Cryo-electron microscopy captures the first 3D structure of SPOP protein that drives cancer

New tool can accurately discover, quantify RNA molecules from error-prone long-read RNA sequencing data

Study reveals the mechanism through which Sirtuin 7 protein suppresses thermogenesis in mice

First-ever computer reconstruction replicates the exact chemical and 3D structure of a 'live' virus

New drug target for Ewing sarcoma discovered

HKUST researchers map out the fundamental mechanisms of C.elegans Microprocessor

Research provides a comprehensive structural framework to design safer pain-relieving drugs

Study explores the role of endocannabinoids in hazardous drinking among young adults

New Pyk2-derived peptide inhibits breast cancer metastasis

Using the power of light to transform analytical workflows in the life sciences

New test 'fishes' for multiple respiratory viruses using DNA as 'bait'

Researchers develop an artificial neuron closely mimicking the characteristics of a biological neuron

Machine learning tools help unravel why human accelerated regions evolved so quickly

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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