Molecular & Structural Biology

RSS

Newfound mechanism helps the heart to toggle between maintenance and energy-boost mode

Researchers at the Centre for Genomic Regulation in Barcelona have discovered a mechanism involving ribosomes which helps the heart toggle between a 'regular maintenance mode' for day-to-day function and an 'energy-boost mode' which aids recovery for high-demand situations including heart attacks.

7 Mar 2023

Mutant mice models created for studying bipolar disorder

Bipolar disorder (BD) is a debilitating condition characterized by alternating states of depression (known as depressive episodes) and abnormal excitement or irritability (known as manic episodes).

7 Mar 2023

Researchers investigate the potential effect of folic acid supplementation on DNA mutation rates

It is well established that folic acid supplementation can significantly reduce the risk of birth defects, including neural tube defects like spina bifida, the most common birth defect of the central nervous system and the second most common of all structural birth defects.

6 Mar 2023

Researchers synthesize fluorescent molecularly imprinted polymeric nanoparticles to detect neurotransmitters

The animal brain consists of tens of billions of neurons or nerve cells that perform complex tasks like processing emotions, learning, and making judgments by communicating with each other via neurotransmitters.

3 Mar 2023

New method enables direct observation of bee brains

An international team of bee researchers involving Heinrich Heine University Düsseldorf has integrated a calcium sensor into honey bees to enable the study of neural information processing including response to odors.

3 Mar 2023

New delivery system based on lipid nanoparticles could increase the efficiency of gene therapy

Lipid nanoparticles have been used to encapsulate CRISPR-Cas9 and deliver it to cells in mice, where it was highly effective at knocking down expression of a target protein.

2 Mar 2023

Researchers use spatial single-cell transcriptome technique to examine immune signatures of SARS-CoV-2-infected lungs

The study findings demonstrate the power of spatial single-cell transcriptomics in studying COVID-19 lung pathology and other health and disease conditions.

1 Mar 2023

Breaking apart certain proteins may offer a pathway to treat Alzheimer's diease

Certain diseases, including Alzheimer's, are currently considered "undruggable" because traditional small molecule drugs can't interfere with the proteins responsible for the illnesses.

1 Mar 2023

New numerical model reveals degeneration mechanisms in mechanically loaded and inflamed cartilage

Understanding how the knee joint environment affects cartilage cells is crucial for joint health. Knowledge of cell-driven cartilage degeneration mechanisms can support the development of effective pharmaceutical interventions for osteoarthritis.

1 Mar 2023

Extended parental provisioning may have played a key role in evolution of larger brains

A review of evidence from prior research provides new support for the possibility that the evolution of larger brains in some species was enabled through increased energy investment by parents in their offspring.

28 Feb 2023

Brain over-activation could be causing seizures and social deficits in genetic subtype of autism

Northwestern Medicine scientists have identified the cause of a genetic subtype of autism and schizophrenia that results in social deficits and seizures in mice and humans.

28 Feb 2023

Study reveals new mechanism in the arms race between bacteria and viruses

UT Southwestern biochemist Zhijian "James" Chen, Ph.D., famously identified the cGAS enzyme pathway that alerts the human immune system to disease-causing invaders like viruses.

28 Feb 2023

Using the origami technique to design RNA nanostructures

Researchers from Aarhus University and Berkeley Laboratory have designed RNA molecules, that folds into nanoscale rectangles, cylinders, and satellites, and have studied their 3D structure and dynamics with advanced nanotechnological methods.

28 Feb 2023

Tecan and Oxford Nanopore build alliance to create automated, seamless and fully compatible nanopore sequencing library preparation for any-length fragments of native DNA/RNA

The Tecan Group and Oxford Nanopore Technologies plc (Oxford Nanopore) today announce their collaboration to drive easier high-throughput nanopore library preparation in an automated, hands-free fashion.

From Tecan 27 Feb 2023

New insights into how amino acids shaped the genetic code of ancient microorganisms

By simulating early Earth conditions in the lab, researchers have found that without specific amino acids, ancient proteins would not have known how to evolve into everything alive on the planet today - including plants, animals, and humans.

27 Feb 2023

Common RNA modification plays a key role in TDP-43-related neurodegeneration in ALS

Nearly 100% of cases of amyotrophic lateral sclerosis - the progressive, fatal neurodegenerative disease known as ALS or Lou Gherig's disease - involve the buildup of a protein called TDP-43.

27 Feb 2023

Different cellular building blocks are not produced at the same time, research shows

Textbooks will tell you that in dividing cells, the production of new DNA peaks during the S-phase, while production of other macromolecules, such as proteins, lipids, and polysaccharides, continues at more or less the same level.

27 Feb 2023

Innovative methodology to detect viral RNA

Experts from the University of Barcelona, the Institute for Advanced Chemistry of Catalonia, the Institute of Microelectronics of Barcelona and the Aragon Nanoscience and Materials Institute of Aragon —a joint institute of the CSIC and the University of Zaragoza— have developed a new method to detect RNA viruses based on the triplex-forming probe technology.

27 Feb 2023

The relationship between DNAm-based age acceleration measures in the prediction of cross-sectional and longitudinal health outcomes and mortality

Researchers assessed the association between deoxyribonucleic acid methylation (DNAm)-based clocks or aging measures and demographic and serological parameters in estimating health-associated outcomes, including deaths.

24 Feb 2023

Fixation Before Dissociation Using a Deep Eutectic Solvent Preserves In Vivo States and Phospho-Signalling in Single-Cell Sequencing Presented

Researchers at the University of Alabama at Birmingham have demonstrated a novel way of fixing cells and preserving their biomolecules prior to single cell dissociation without the need for harsh enzymatic/mechanical approaches.

From Rapid Labs Ltd 24 Feb 2023

Molecular & Structural Biology

Newfound mechanism helps the heart to toggle between maintenance and energy-boost mode

Mutant mice models created for studying bipolar disorder

Researchers investigate the potential effect of folic acid supplementation on DNA mutation rates

Researchers synthesize fluorescent molecularly imprinted polymeric nanoparticles to detect neurotransmitters

New method enables direct observation of bee brains

New delivery system based on lipid nanoparticles could increase the efficiency of gene therapy

Researchers use spatial single-cell transcriptome technique to examine immune signatures of SARS-CoV-2-infected lungs

Breaking apart certain proteins may offer a pathway to treat Alzheimer's diease

New numerical model reveals degeneration mechanisms in mechanically loaded and inflamed cartilage

Extended parental provisioning may have played a key role in evolution of larger brains

Brain over-activation could be causing seizures and social deficits in genetic subtype of autism

Study reveals new mechanism in the arms race between bacteria and viruses

Using the origami technique to design RNA nanostructures

Tecan and Oxford Nanopore build alliance to create automated, seamless and fully compatible nanopore sequencing library preparation for any-length fragments of native DNA/RNA

New insights into how amino acids shaped the genetic code of ancient microorganisms

Common RNA modification plays a key role in TDP-43-related neurodegeneration in ALS

Different cellular building blocks are not produced at the same time, research shows

Innovative methodology to detect viral RNA

The relationship between DNAm-based age acceleration measures in the prediction of cross-sectional and longitudinal health outcomes and mortality

Fixation Before Dissociation Using a Deep Eutectic Solvent Preserves In Vivo States and Phospho-Signalling in Single-Cell Sequencing Presented

Extending the reach of Amperia™

Modular cleanrooms: Enhancing flexibility and compliance

Redefining control and consistency in anaerobic microbiome workflows

Latest Life Science News