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FDA grants Orphan Drug Designation to CD4CAR therapy for treatment of peripheral T-cell lymphoma

iCell Gene Therapeutics today (Aug. 11) announced that the Food and Drug Administration has granted Orphan Drug Designation for its chimeric antigen receptor engineered T-cells directed against the target protein CD4 (CD4CAR) for the treatment of peripheral T-cell lymphoma (PTCL).

12 Aug 2016

Specific molecular features control uptake of biguanides into mitochondria to inhibit respiration

The biguanides are a family of drugs with diverse clinical applications. Metformin, a widely used anti-hyperglycemic biguanide, suppresses mitochondrial respiration by inhibiting respiratory complex I. Phenformin, a related anti-hyperglycemic biguanide, also inhibits respiration, but proguanil, which is widely used for the prevention of malaria, does not.

12 Aug 2016

Opioid naive individuals at low risk of developing persistent opioid use after surgery, research shows

Researchers from the University Health Network's Department of Anesthesia and Pain Management and the Institute for Clinical Evaluative Sciences have determined that patients who have not had an opioid prescription within a year prior to their procedure are at low risk of developing persistent opioid use after major surgery.

11 Aug 2016

Scientists identify potential mechanism that paves way for improved treatment of fungal infections

By identifying new compounds that selectively block mitochondrial respiration in pathogenic fungi, Whitehead Institute scientists have identified a potential antifungal mechanism that could enable combination therapy with fluconazole, one of today's most commonly prescribed fungal infection treatments.

11 Aug 2016

Research finding opens new avenues to tailor drug development with Upsalite

For the first time, researchers have revealed the nanostructure of the mesoporous magnesium carbonate Upsalite and pore size control was achieved without organic templates or swelling agents.

11 Aug 2016

Researchers uncover one way breast cancer tumors resist vital medication

A team of Case Western Reserve University School of Medicine cancer researchers has uncovered one way certain tumors resist vital medication.

11 Aug 2016

First investigational treatment for infantile-onset SMA shows promising results in clinical trial

A major milestone was reached when nusinersen, an investigational treatment for spinal muscular atrophy (SMA), was shown to significantly improve achievement of motor milestones in babies with infantile-onset SMA, according to an interim analysis of the double-blind, randomized, placebo controlled Phase 3 clinical trial called ENDEAR.

11 Aug 2016

New drug provides considerable added benefit in treating adults with advanced renal cell cancer

Nivolumab has been approved since April 2016 as a checkpoint inhibitor for the treatment of adults with advanced renal cell cancer who have already undergone prior therapy.

11 Aug 2016

Commonly used anti-inflammatory drug shows potential to treat Alzheimer's disease

A research project has shown that an experimental model of Alzheimer's disease can be successfully treated with a commonly used anti-inflammatory drug.

11 Aug 2016

Drug approved for treatment of vulvovaginal atrophy shows no added benefit in post-menopausal women

Ospemifene (tradename: Senshio) is approved for the treatment of moderate to severe symptomatic vulvovaginal atrophy (VVA) in post-menopausal women who are not candidates for local vaginal oestrogen therapy.

11 Aug 2016

RNA silencing technique developed by spinoff from UM-Madison effective in battling hepatitis B

A method for "silencing" RNA that emerged from a University of Wisconsin-Madison spinoff company is in clinical trials in Europe, Asia and the United States against hepatitis B, an infection that can destroy the liver.

11 Aug 2016

New research could lead to improved treatment for depression

SCIENTISTS at the University of Huddersfield led by Dr Patrick McHugh have embarked on a project that could lead to a more effective treatment for depression.

10 Aug 2016

Study finds oral immunotherapy safe, effective at suppressing peanut allergy in preschool children

Nearly 80 percent of peanut-allergic preschool children successfully incorporated peanut-containing foods into their diets after receiving peanut oral immunotherapy (OIT), a clinical trial has found.

10 Aug 2016

New technology uses natural nano-scale lipid transport system to deliver drugs straight to bloodstream

For years scientists and dieticians have argued over the health benefits of dietary fat. Research published this week, however, shows that piggybacking onto natural fat absorption pathways can dramatically enhance the utility of some drugs.

10 Aug 2016

Commonly-used stroke prevention drug may not control blood clotting over long term

Warfarin prescribed to prevent strokes in atrial fibrillation may not adequately control blood clotting over the long-term, even when patients have been historically stable on the drug, according to a study from the Duke Clinical Research Institute.

9 Aug 2016

Research findings could lead to development of improved breast cancer drugs

Biomedical scientists have revealed the inner workings of a group of proteins that help to switch critical genes on and off during blood-cell production, in a finding that could lead to the development of new and improved cancer drugs.

9 Aug 2016

Penn study shows synchronized refill program enhances medication adherence

Programs aimed at helping patients adhere to prescription medication regimens have become an area of interest for researchers as nearly half of patients do not take medications as prescribed.

9 Aug 2016

Study finds racial-ethnic disparities in emergency department opioid prescription for pain-related conditions

Dr. Astha Singhal, Assistant Professor in the Department of Health Policy and Health Services Research at Boston University Henry M. Goldman School of Dental Medicine, published a study that found a racial disparity in opioid prescriptions for emergency department visits for non-definitive pain-related conditions.

9 Aug 2016

Antiepileptic drugs for reducing seizures may induce psychotic disorders, study shows

Today Brain publishes a new study indicating that antiepileptic drugs designed to reduce seizures, may also induce psychotic disorders in some patients.

9 Aug 2016

Study finds no major difference in effectiveness of two classes of drugs in peritoneal dialysis patients

With cardiovascular disease being the No. 1 cause of death in end-stage kidney disease patients on peritoneal dialysis, a new study examined two classes of medications commonly prescribed to prevent cardiovascular events in these patients and found no significant difference in outcomes.

9 Aug 2016

Pharmaceutical News

FDA grants Orphan Drug Designation to CD4CAR therapy for treatment of peripheral T-cell lymphoma

Specific molecular features control uptake of biguanides into mitochondria to inhibit respiration

Opioid naive individuals at low risk of developing persistent opioid use after surgery, research shows

Scientists identify potential mechanism that paves way for improved treatment of fungal infections

Research finding opens new avenues to tailor drug development with Upsalite

Researchers uncover one way breast cancer tumors resist vital medication

First investigational treatment for infantile-onset SMA shows promising results in clinical trial

New drug provides considerable added benefit in treating adults with advanced renal cell cancer

Commonly used anti-inflammatory drug shows potential to treat Alzheimer's disease

Drug approved for treatment of vulvovaginal atrophy shows no added benefit in post-menopausal women

RNA silencing technique developed by spinoff from UM-Madison effective in battling hepatitis B

New research could lead to improved treatment for depression

Study finds oral immunotherapy safe, effective at suppressing peanut allergy in preschool children

New technology uses natural nano-scale lipid transport system to deliver drugs straight to bloodstream

Commonly-used stroke prevention drug may not control blood clotting over long term

Research findings could lead to development of improved breast cancer drugs

Penn study shows synchronized refill program enhances medication adherence

Study finds racial-ethnic disparities in emergency department opioid prescription for pain-related conditions

Antiepileptic drugs for reducing seizures may induce psychotic disorders, study shows

Study finds no major difference in effectiveness of two classes of drugs in peritoneal dialysis patients

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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