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Traditional Chinese medicinal plant produces compounds that may help to kill human cancers

New research led by Professor Cathie Martin of the John Innes Centre has revealed how a plant used in traditional Chinese medicine produces compounds which may help to treat cancer and liver diseases.

11 Apr 2016

Chemists design set of molecules that promote microscopic, anatomical changes in neurons

Chemists at the University of California San Diego have designed a set of molecules that promote microscopic, anatomical changes in neurons associated with the formation and retention of memories. These drug candidates also prevent deterioration of the same neuronal structures in the presence of amyloid-beta, a protein fragment that accumulates in the brains of people with Alzheimer's disease.

11 Apr 2016

Innovative HIV vaccine candidate generates protection against repeated AIDS virus exposures

Mymetics Corporation, a pioneer in the research and development of virosome-based vaccines to prevent transmission of human infectious diseases across mucosal membranes, announced today that its innovative HIV vaccine candidate has shown to generate significant protection in groups of twelve female monkeys against repeated AIDS virus exposures during part of the preclinical study.

11 Apr 2016

New U of T study shows that acetaminophen could impede error-detection in the brain

It's been known for more than a century that acetaminophen is an effective painkiller, but according to a new U of T study it could also be impeding error-detection in the brain.

11 Apr 2016

HPV vaccination may be beneficial for CKD patients but not for kidney transplant recipients

Human papillomavirus (HPV) vaccination stimulates robust and sustained immune responses in girls and young women with chronic kidney disease (CKD) and those on dialysis, but less optimal responses to the vaccine were observed among those with a kidney transplant.

11 Apr 2016

Cigarette smoking, viral infections may reduce effectiveness of COPD symptom-reliever medication

New study backs up observations in Chronic Obstructive Pulmonary Disease (COPD) patients showing reduced effectiveness of symptom-reliever medication (β2-adrenoceptor agonists) in flare-ups linked to cigarette smoking and infection with viruses such as influenza.

11 Apr 2016

High–performance, cost-effective NMR solutions for the pharmaceutical and chemical industries

At the 57th Experimental Nuclear Magnetic Resonance Conference (www.enc-conference.org), Bruker is showcasing several innovative drug discovery, drug development and process control solutions for small molecule NMR characterization in the chemical and pharmaceutical industries.

From Bruker BioSpin Group 11 Apr 2016

Novel nanoparticle drug delivery system for enhanced tumor penetration of cancer drugs

For more than a decade, biomedical researchers have been looking for better ways to deliver cancer-killing medication directly to tumors in the body. Tiny capsules, called nanoparticles, are now being used to transport chemotherapy medicine through the bloodstream, to the doorstep of cancerous tumors.

11 Apr 2016

Added benefit of crizotinib drug for first-line treatment of advanced bronchial carcinoma not proven

The drug crizotinib (trade name: Xalkori) has been available since 2012 for patients with advanced non-small cell lung cancer (bronchial carcinoma) who have a high activity of the enzyme anaplastic lymphoma kinase (ALK) and have already received another treatment. In November 2015, the approval was extended to first-line treatment.

11 Apr 2016

Long-term medication use reduces risk of relapse and improves symptoms in BDD patients

People with Body Dysmorphic Disorder (BDD) fare better and are less likely to relapse when treated with medication on a long-term basis, according to researchers at Rhode Island Hospital and Massachusetts General Hospital.

11 Apr 2016

AstraZeneca, MedImmune to present new clinical trial and scientific data on lung cancer treatments at ELCC 2016

AstraZeneca and its global biologics research and development arm, MedImmune, will report new clinical trial and scientific data from their industry-leading lung cancer franchise of marketed and pipeline medicines at the European Lung Cancer Conference in Geneva, Switzerland, 13 -16 April 2016.

11 Apr 2016

Researchers identify severe side effects of Clozapine drug

Clozapine (CLZ) is a "gold standard" drug for managing treatment-resistant schizophrenia (TRS), who do not respond adequately to first-line antipsychotics.

7 Apr 2016

Entresto drug shows added benefit in symptomatic chronic heart failure

The fixed-dose combination of sacubitril and valsartan (trade name: Entresto) has been approved since November 2015 for adults with symptomatic chronic heart failure with reduced pump function (ejection fraction). The German Institute for Quality and Efficiency in Health Care (IQWiG) now examined in an early benefit assessment whether this drug combination offers an added benefit for patients in comparison with the appropriate comparator therapy.

7 Apr 2016

Phenotypic personalized medicine can identify a person's optimal drug, dose combinations

For decades, doctors and scientists have predicted that personalized medicine — tailoring drug doses and combinations to people's specific diseases and body chemistry — would be the future of health care.

7 Apr 2016

Resuscitation drugs along with defibrillation shocks can help stabilize heart beat after cardiac arrest

Administering heart resuscitation drugs to patients whose cardiac arrest is witnessed at the time of the attack can improve survival, but needs to be done through an IV line rather than directly into bone marrow as is more commonly done by paramedics, a new study involving UT Southwestern Medical Center emergency physicians and Dallas-Fort Worth Emergency Medical Services agencies reveals.

7 Apr 2016

New extended-release pills could reduce dosage frequency of some drugs

Researchers from MIT and Brigham and Women's Hospital have designed a new type of pill that, once swallowed, can attach to the lining of the gastrointestinal tract and slowly release its contents. The tablet is engineered so that one side adheres to tissue, while the other repels food and liquids that would otherwise pull it away from the attachment site.

7 Apr 2016

Electronic prescribing may lead to improved patient safety, efficient prescription process

As New York State shifts away from paper prescriptions, an Albany Medical Center physician leader says electronic prescribing, or "e-prescribing," will lead to improved patient safety and a more efficient prescription process.

7 Apr 2016

Taking epilepsy drug during pregnancy may not increase risk of birth defects

Babies born to pregnant women taking the epilepsy drug lamotrigine may not be at an increased risk of birth defects, such as cleft lip, cleft palate or clubfoot, according to a study published in the April 6, 2016, online issue of Neurology, the medical journal of the American Academy of Neurology.

7 Apr 2016

Compound from unique blue-green algae could be key to next anti-cancer drug

Could a slippery glob of algae hold the key to the next anti-cancer drug? According to new research into a compound produced by a unique community of blue-green algae, the answer could be yes.

7 Apr 2016

New immune-suppressing therapy leads to longer survival for cross-species heart transplant

A new immune-suppressing therapy has led to the longest survival yet for a cross-species heart transplant, according to new research conducted in part by researchers at the University of Maryland School of Medicine.

7 Apr 2016

Pharmaceutical News

Traditional Chinese medicinal plant produces compounds that may help to kill human cancers

Chemists design set of molecules that promote microscopic, anatomical changes in neurons

Innovative HIV vaccine candidate generates protection against repeated AIDS virus exposures

New U of T study shows that acetaminophen could impede error-detection in the brain

HPV vaccination may be beneficial for CKD patients but not for kidney transplant recipients

Cigarette smoking, viral infections may reduce effectiveness of COPD symptom-reliever medication

High–performance, cost-effective NMR solutions for the pharmaceutical and chemical industries

Novel nanoparticle drug delivery system for enhanced tumor penetration of cancer drugs

Added benefit of crizotinib drug for first-line treatment of advanced bronchial carcinoma not proven

Long-term medication use reduces risk of relapse and improves symptoms in BDD patients

AstraZeneca, MedImmune to present new clinical trial and scientific data on lung cancer treatments at ELCC 2016

Researchers identify severe side effects of Clozapine drug

Entresto drug shows added benefit in symptomatic chronic heart failure

Phenotypic personalized medicine can identify a person's optimal drug, dose combinations

Resuscitation drugs along with defibrillation shocks can help stabilize heart beat after cardiac arrest

New extended-release pills could reduce dosage frequency of some drugs

Electronic prescribing may lead to improved patient safety, efficient prescription process

Taking epilepsy drug during pregnancy may not increase risk of birth defects

Compound from unique blue-green algae could be key to next anti-cancer drug

New immune-suppressing therapy leads to longer survival for cross-species heart transplant

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Bioprocess Efficiency with Cell Density Monitoring

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