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Infected mice can be better models for human diseases

Vaccines and therapeutics developed using mice often don't work as expected in humans. New research at Washington University School of Medicine in St. Louis points to the near-sterile surroundings of laboratory mice as a key reason.

21 Apr 2016

Novel combination of cancer drugs can have therapeutic impact on diffuse large B-cell lymphoma

New research from Roswell Park Cancer Institute shows that promising cancer drugs used in combination can have significant therapeutic impact on a particularly aggressive subtype of diffuse large B-cell lymphoma (DH-DLBCL) in preclinical studies. The researchers will present their findings at the American Association for Cancer Research (AACR) Annual Meeting 2016, to be held April 16-20 in New Orleans.

21 Apr 2016

TSRI chemists develop new method to achieve chemical reaction in pharmaceutical industry

Scientists at The Scripps Research Institute have found a new and better way to achieve a chemical reaction that is used widely in the pharmaceutical as well as flavor and fragrance industries.

21 Apr 2016

Motivational interviewing can help reduce risky use of pain pills

As America battles an epidemic of deaths from misused pain pills, a new study suggests an inexpensive way to cut risky use of these drugs by people who have a high chance of overdosing.

21 Apr 2016

Drugs that block NOTCH signaling in many cancers could be effective against ACC

Using a novel cell culture approach, Yale Cancer Center researchers have discovered critical vulnerabilities in adenoid cystic carcinoma (ACC), a rare and lethal glandular cancer with a high recurrence rate and few treatment options.

21 Apr 2016

Clinical study shows watercress extract inhibits carcinogen activation in cigarette smokers

Watercress extract taken multiple times a day significantly inhibits the activation of a tobacco-derived carcinogen in cigarette smokers, researchers at the University of Pittsburgh Cancer Institute, partner with UPMC Cancer Center, demonstrated in a phase II clinical trial presented today at the American Association for Cancer Research Annual Meeting in New Orleans.

21 Apr 2016

Researchers reposition existing prazosin drug to combat glioblastoma

Treatments available for glioblastoma—malignant brain tumors—have little effect. An international collaboration led by the Laboratoire Neurosciences Paris-Seine tested active ingredients from existing medications and eventually identified one compound of interest, prazosin, on these tumors. Not only did it seem to be effective in this type of cancer, but it also acted on a signaling pathway that is common with other cancers.

21 Apr 2016

Antidepressant Wellbutrin linked to long-term modest weight loss

Group Health researchers have found that bupropion (marketed as Wellbutrin) is the only antidepressant that tends to be linked to long-term modest weight loss.

21 Apr 2016

Multivitamin use prior to diagnosis may reduce effects of CIPN in breast cancer survivors

Researchers at Roswell Park Cancer Institute, in collaboration with investigators from the cooperative group SWOG, have found that use of multivitamins prior to diagnosis may reduce the risk of neuropathy in breast cancer patients treated with the class of drugs known as taxanes. The team will present their findings at the American Association for Cancer Research Annual Meeting 2016, to be held April 16-20 in New Orleans.

21 Apr 2016

WHO outlines steps to close immunization gap across countries during World Immunization Week 2016

During World Immunization Week 2016, held 24-30 April, the World Health Organization highlights recent gains in immunization coverage, and outlines further steps countries can take to “Close the Immunization Gap” and meet global vaccination targets by 2020.

21 Apr 2016

NPS MedicineWise reminds Australians to prevent overuse and misuse of antibiotics

Following from last night’s Catalyst episode, ‘Antibiotic Resistance’ on ABC TV examining Australia’s profligate use of antibiotics, NPS MedicineWise is reminding Australians to preserve the miracle of antibiotics by avoiding antibiotics when they’re not needed.

21 Apr 2016

Angola' health officials extend vaccination campaign for yellow fever to Huambo and Benguela provinces

As Angola grapples with its worst yellow fever outbreak in decades, the Ministry of Health, with the support of the World Health Organization and partners have extended the vaccination campaign beyond the capital Luanda into Huambo and Benguela – 2 of the other 5 provinces reporting local transmission.

21 Apr 2016

Adding CYP24A1 inhibitors may improve antitumor activity of vitamin D

Roswell Park Cancer Institute research on the most potent form of vitamin D, commonly called calcitriol, offers new insights into approaches that may enhance the antitumor activity of this much-studied human hormone.

20 Apr 2016

Hormonal contraception may increase susceptibility of women to genital infection

Women account for approximately half of all individuals living with HIV worldwide, and researchers wanted to identify the risk factors that increase susceptibility of women to genital infection.

20 Apr 2016

Scientists develop new drug for life-threatening lung disease treatment

Researchers are developing a new drug to treat life-threatening lung damage and breathing problems in people with severe infections like pneumonia, those undergoing certain cancer treatments and premature infants with underdeveloped, injury prone lungs.

20 Apr 2016

New mouse model to aid in development of antiviral compounds, vaccines against Zika virus

Researchers at the University of Wisconsin-Madison School of Veterinary Medicine have developed one of the first mouse models for the study of Zika virus. The model will allow researchers to better understand how the virus causes disease and aid in the development of antiviral compounds and vaccines.

20 Apr 2016

Experimental treatment shrinks rare pediatric tumor by 90%

When a baby's life was threatened by a rare pediatric cancer that would not respond to surgery or chemotherapy, doctors at Nemours Children's Hospital rapidly, successfully shrank the tumor by 90 percent using an experimental treatment, according to a new study published online in Pediatric Blood and Cancer.

20 Apr 2016

New study suggests re-evaluation of long-held method to predict effectiveness of seasonal influenza vaccine

The long-held approach to predicting seasonal influenza vaccine effectiveness may need to be revisited, new research suggests. Currently, seasonal flu vaccines are designed to induce high levels of protective antibodies against hemagglutinin (HA), a protein found on the surface of the influenza virus that enables the virus to enter a human cell and initiate infection.

20 Apr 2016

Herceptin drugs for breast cancer linked with increased risk of congestive heart failure

Breast cancer patients undergoing treatment with trastuzumab-containing regimens should be monitored for heart damage regardless of age. This is among the findings of a new study from the Peter Munk Cardiac Centre, the Institute for Clinical Evaluative Sciences (ICES) and the Ted Rogers Centre for Heart Research, University Health Network.

20 Apr 2016

Aspirin use linked with reduced risk of developing bile duct cancer

A team of current and former Mayo Clinic researchers has discovered that aspirin use is associated with a significantly reduced risk of developing bile duct cancer, also called cholangiocarcinoma. The results are published in Hepatology.

20 Apr 2016

Pharmaceutical News

Infected mice can be better models for human diseases

Novel combination of cancer drugs can have therapeutic impact on diffuse large B-cell lymphoma

TSRI chemists develop new method to achieve chemical reaction in pharmaceutical industry

Motivational interviewing can help reduce risky use of pain pills

Drugs that block NOTCH signaling in many cancers could be effective against ACC

Clinical study shows watercress extract inhibits carcinogen activation in cigarette smokers

Researchers reposition existing prazosin drug to combat glioblastoma

Antidepressant Wellbutrin linked to long-term modest weight loss

Multivitamin use prior to diagnosis may reduce effects of CIPN in breast cancer survivors

WHO outlines steps to close immunization gap across countries during World Immunization Week 2016

NPS MedicineWise reminds Australians to prevent overuse and misuse of antibiotics

Angola' health officials extend vaccination campaign for yellow fever to Huambo and Benguela provinces

Adding CYP24A1 inhibitors may improve antitumor activity of vitamin D

Hormonal contraception may increase susceptibility of women to genital infection

Scientists develop new drug for life-threatening lung disease treatment

New mouse model to aid in development of antiviral compounds, vaccines against Zika virus

Experimental treatment shrinks rare pediatric tumor by 90%

New study suggests re-evaluation of long-held method to predict effectiveness of seasonal influenza vaccine

Herceptin drugs for breast cancer linked with increased risk of congestive heart failure

Aspirin use linked with reduced risk of developing bile duct cancer

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

Digital pathology and the PathoVerse: A conversation with Dr. Singh

Bioprocess Efficiency with Cell Density Monitoring

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