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Aerosolized ACE2 neutralizes COVID-19 variants in lab and mice tests

Researchers from the University of Texas Southwestern have developed an aerosolized, mutated form of ACE2 that effectively neutralizes various SARS-CoV-2 variants in both cell cultures and mice. The study suggests that this modified ACE2 has promising preventive and therapeutic potential against COVID-19, especially with its easy aerosolized administration.

28 Sep 2023

Vaxzevria vaccine boosts mucosal immunity in COVID-19 recovered

Study highlights the ability of the Vaxzevria vaccine in inducing robust mucosal antibody responses, especially in COVID-19-recovered individuals, showcasing a notable defense against various SARS-CoV-2 variants. However, it emphasizes the need for booster doses to enhance anti-SARS-CoV-2 mucosal immunity, especially in infection-naïve individuals, to broaden protection against emerging viral variants.

28 Sep 2023

Commonly used anti-viral drugs reduce risk of hospitalization, death in patients with mild COVID-19

New Cleveland Clinic-led research shows commonly used COVID-19 anti-viral drugs Paxlovid (nirmatrelvir) and Lagevrio (molnupiravir) reduce risk of hospitalization and death in high-risk patients with mild disease, even with Omicron subvariants.

28 Sep 2023

How does taking a pause on the oral contraceptive pill impact mental health?

Users of combination oral contraceptive agents experience one time per month (pill break) was connected with mood changes.

28 Sep 2023

Could next-generation antimicrobial agents act as an alternative to standard antibiotics?

Next-generation antimicrobial agents (NGAs) as a potential alternative to standard antibiotics

26 Sep 2023

One health wake-up call: London's river data highlights environmental perils

The largest-ever spatiotemporal monitoring of chemicals/contaminants of emerging concern (CECs) in London waterways.

26 Sep 2023

Monkeypox mimics smallpox vaccine's immune response, new study reveals

The study in Nature Communications reveals that MPOX infection triggers an anti-viral antibody response akin to that from smallpox vaccination. Utilizing a comprehensive array of ELISAs, scientists found a high level of specificity and sensitivity in detecting antibodies against both MPOX and smallpox, offering a new, accurate way to measure immune responses.

26 Sep 2023

Intranasal vaccine shows promise against COVID variants in hamsters

Intranasal mRNA-LNP vaccines show promise in Syrian golden hamsters, effectively reducing SARS-CoV-2 viral loads and lung pathology. The study suggests potential efficacy against new variants, setting the stage for future research in human applications.

25 Sep 2023

Antibiotics can sometimes benefit bacteria

Scientists have found a surprising effect of some antibiotics on certain bacteria – that the drugs can sometimes benefit bacteria, helping them live longer.

25 Sep 2023

Study: Most patients prescribed fewer opioids after surgery satisfied with pain control

In a recent Mayo Clinic study, researchers found that most patients prescribed fewer opioids after surgery were able to maintain satisfactory comfort levels without requiring more prescription refills later.

25 Sep 2023

Research could lead to the development of new weight-loss drug that mimics exercise

A brand-new kind of drug, tested in mice, shows promising new results that could lead to the development of a new weight-loss drug that mimics exercise.

25 Sep 2023

COVID drug molnupiravir appears to be driving SARS-CoV-2 to mutate and evolve

Molnupiravir, an antiviral drug used to treat patients with COVID-19, appears to be driving SARS-CoV-2 to mutate and evolve, with some of these new viruses being transmitted onwards, a new study has shown. It is not clear, however, whether these mutated viruses pose an increased risk to patients or are able to evade the vaccine.

25 Sep 2023

Researchers develop new method to deliver strong antibiotic drugs more safely

Antibiotic resistant bacteria are a threat to human lives, and yet the development of new drugs to treat bacterial infections is slow.

25 Sep 2023

Finnish study finds revised dementia guidelines did not reduce psychotropic use

A recent register-based study examined the impact of Finland's revised clinical guidelines for the treatment of dementia, published in 2017, on the trend of users of psychotropics in older people with dementia in 2009-2020.

25 Sep 2023

Once-weekly ALTUVIIIO® approved in Japan as a new class of factor VIII therapy for hemophilia A

The Japanese Ministry of Health, Labor, and Welfare (MHLW) has granted marketing authorization for ALTUVIIIO.

From Sanofi 25 Sep 2023

Tirzepatide outshines other treatments in lowering blood sugar and weight for type 2 diabetes patients

Meta-analysis finds tirzepatide to be the most effective GLP-1 receptor agonist for glucose and weight control in type 2 diabetes patients. The study suggests tirzepatide could be preferable in initial stages of the disease, while other GLP-1 receptor agonists combined with insulin are equally effective for long-term diabetics.

25 Sep 2023

Could metformin be a game changer for heart health in non-diabetics?

Using Mendelian randomization, researchers found that altering seven metformin targets led to improved blood pressure and BMI in non-diabetic individuals. The study suggests the potential for metformin's role in reducing cardiovascular risks in the general population, although more research is needed.

24 Sep 2023

Machine learning speeds up virtual drug screening by 10-fold

Boosting virtual screening with machine learning allowed for a 10-fold time reduction in the processing of 1.56 billion drug-like molecules. Researchers from the University of Eastern Finland teamed up with industry and supercomputers to carry out one of the world's largest virtual drug screens.

22 Sep 2023

Tirzepatide superior to semaglutide for blood sugar control and body weight loss

A new meta-analysis combining 22 studies, to be presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD) in Hamburg, Germany (2-6 October), shows that tirzepatide is superior to semaglutide for both control of blood sugar and in terms of amount of body weight lost by patients.

22 Sep 2023

Can COVID-19 vaccines turn the tide on long-haul symptoms?

The study finds that COVID-19 vaccination can significantly reduce symptoms and improve well-being in patients suffering from post-COVID-19 conditions (PCC). Vaccination also lowered systemic markers of inflammation but did not entirely eliminate persistent SARS-CoV-2 antigens, which may continue to contribute to inflammation.

22 Sep 2023

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Pharmaceutical News

Aerosolized ACE2 neutralizes COVID-19 variants in lab and mice tests

Vaxzevria vaccine boosts mucosal immunity in COVID-19 recovered

Commonly used anti-viral drugs reduce risk of hospitalization, death in patients with mild COVID-19

How does taking a pause on the oral contraceptive pill impact mental health?

Could next-generation antimicrobial agents act as an alternative to standard antibiotics?

One health wake-up call: London's river data highlights environmental perils

Monkeypox mimics smallpox vaccine's immune response, new study reveals

Intranasal vaccine shows promise against COVID variants in hamsters

Antibiotics can sometimes benefit bacteria

Study: Most patients prescribed fewer opioids after surgery satisfied with pain control

Research could lead to the development of new weight-loss drug that mimics exercise

COVID drug molnupiravir appears to be driving SARS-CoV-2 to mutate and evolve

Researchers develop new method to deliver strong antibiotic drugs more safely

Finnish study finds revised dementia guidelines did not reduce psychotropic use

Once-weekly ALTUVIIIO® approved in Japan as a new class of factor VIII therapy for hemophilia A

Tirzepatide outshines other treatments in lowering blood sugar and weight for type 2 diabetes patients

Could metformin be a game changer for heart health in non-diabetics?

Machine learning speeds up virtual drug screening by 10-fold

Tirzepatide superior to semaglutide for blood sugar control and body weight loss

Can COVID-19 vaccines turn the tide on long-haul symptoms?

Fluidics in Modern Healthcare & Medical Device Innovation

Scaling 3D biology: Automation, imaging, and the future of high-throughput research

How does norepinephrine influence anxiety-related behaviours?

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