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Anti-Omicron antibodies are induced by hypermutation with ancestral BNT162b2 COVID vaccine

Scientists from the Republic of Korea have analyzed B-cell receptor repertoires induced by an mRNA-based coronavirus disease 2019 (COVID-19) vaccine and found that somatic hypermutations in B-cell receptor heavy chain are responsible for broadening its specificity for unexposed antigens.

16 Mar 2023

Real-world data on the effectiveness of Sotrovimab as a prophylactic against COVID-19

In a recent study posted in the medRxiv* preprint server, scientists assessed the efficacy of sotrovimab for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) treatment.

16 Mar 2023

Ipsilateral vaccination improves response to second dose of COVID-19 vaccine

Researchers examine whether the involvement of the ipsilateral or contralateral lymph nodes affected the immune response during sequential vaccination.

16 Mar 2023

A novel pan-sarbecovirus vaccine candidate neutralizes Omicron BQ.1.1 and XBB subvariants

Researchers provide evidence that a novel vaccine candidate robustly neutralized SARS-CoV-2 Omicron subvariants BQ.1.1 and XBB.

16 Mar 2023

AI-based drug interaction prediction technology analyzes the interaction between Paxlovid ingredients

KAIST (President Kwang Hyung Lee) announced on the 16th that an advanced AI-based drug interaction prediction technology developed by the Distinguished Professor Sang Yup Lee's research team in the Department of Biochemical Engineering that analyzed the interaction between the PaxlovidTM ingredients that are used as COVID-19 treatment and other prescription drugs was published as a thesis.

16 Mar 2023

Bormioli Pharma announces robust growth in its North American business in 2022

Bormioli Pharma, a global leader partnering with customers to provide comprehensive packaging solutions for injectable drugs, today announced robust growth in its North American business in 2022, with sales increasing more than 40% year-over-year.

16 Mar 2023

Efficacy of a single dose of MVA-BN smallpox vaccine against Mpox

A recent The Lancet Infectious Disease study focussed on estimating the effectiveness of a single dose of MVA-BN against Mpox in England. This observational study was conducted following the large-scale vaccination program that immunized the GBMSM group with the MVA-BN vaccine.

15 Mar 2023

Four COVID-19 booster doses most effective way to prevent critical Omicron BA.5

A study published in JAMA Network Open explores the protective efficacy of previous exposure to omicron subvariants and booster vaccination against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) omicron BA.5 infection.

15 Mar 2023

Smoking cessation drug may help people stop using cocaine while in treatment for OUD

For some people receiving methadone for treatment of opioid use disorder (OUD), the co-use of opioids and stimulants such as cocaine is an issue.

15 Mar 2023

Owlstone Medical Enters Partnership with Bicycle Therapeutics for the Development of Antigen-Targeted EVOC Probes for Early Cancer Detection

Owlstone Medical, the global leader in Breath Biopsy® announced that it has entered into a Research Agreement with Bicycle Therapeutics plc.

15 Mar 2023

New CDC opioid guidelines: Too little, too late for chronic pain patients?

Jessica Layman estimates she has called more than 150 doctors in the past few years in her search for someone to prescribe opioids for her chronic pain.

15 Mar 2023

Bormioli Pharma North America sales grew by more than 40% in 2022

From Bormioli Pharma S.p.A. 15 Mar 2023

Lassa virus vaccine induces rapid protection in an animal model

Scientists have developed a novel Lassa vaccine using a recombinant measles virus and tested its protective efficacy against Lassa fever. A single vaccine dose has been found to induce a rapid and robust immune response in monkeys with pre-existing immunity against the measles virus.

14 Mar 2023

Bispecific antibody shows improved efficacy against SARS-CoV-2 variants

Researchers from The University of Texas MD Anderson Cancer Center have developed fully human bispecific antibodies, as revealed in a recent study. These antibodies can bind to two distinct epitopes of the receptor binding domain (RBD) of the SARS-CoV-2 spike protein and have demonstrated the ability to neutralize various strains of the virus, including the Omicron variant.

14 Mar 2023

Why does insulin cost so much? Big Pharma isn’t the only player driving prices

Eli Lilly & Co.'s announcement that it is slashing prices for its major insulin products could make life easier for some diabetes patients while easing pressure on Big Pharma.

9 Mar 2023

Statin-related residual inflammation predicts cardiovascular events and mortality

A recent Lancet study assessed the importance of low-density lipoprotein cholesterol (LDLC) and high-sensitivity C-reactive protein (CRP) as risk predictors of cardiovascular death, cardiovascular events, and all-cause death among patients subjected to statins.

7 Mar 2023

FDA mandate to limit the dosage of acetaminophen linked to reductions in serious liver injury

A United States Food and Drug Administration mandate to limit the dosage of acetaminophen in pills that combine acetaminophen and opioid medications is significantly associated with subsequent reductions in serious liver injury, according to a study led by investigators at the University of Alabama and Weill Cornell Medicine.

7 Mar 2023

Decades of substantial U.S. Government investment in mRNA technology paved way for COVID-19 vaccines

Researchers explore the United States public funding for the development of COVID-19 mRNA vaccines.

6 Mar 2023

Antibody levels from prime COVID-19 mRNA vaccine influences the efficacy of booster doses

Researchers evaluate the response of pre-existing immunity to booster doses of mRNA COVID-19 vaccines.

6 Mar 2023

Non-critically ill hospitalized Covid-19 patients could substantially benefit from a higher dose of blood-thinners

Giving noncritically ill patients hospitalized for COVID-19 a higher dose of blood-thinning medication than usual did not significantly reduce the combined risk of death from any cause, need for treatment in an intensive-care unit, a confirmed blood clot or a stroke at 30 days, according to the results of the FREEDOM-COVID trial presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

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Pharmaceutical News

Anti-Omicron antibodies are induced by hypermutation with ancestral BNT162b2 COVID vaccine

Real-world data on the effectiveness of Sotrovimab as a prophylactic against COVID-19

Ipsilateral vaccination improves response to second dose of COVID-19 vaccine

A novel pan-sarbecovirus vaccine candidate neutralizes Omicron BQ.1.1 and XBB subvariants

AI-based drug interaction prediction technology analyzes the interaction between Paxlovid ingredients

Bormioli Pharma announces robust growth in its North American business in 2022

Efficacy of a single dose of MVA-BN smallpox vaccine against Mpox

Four COVID-19 booster doses most effective way to prevent critical Omicron BA.5

Smoking cessation drug may help people stop using cocaine while in treatment for OUD

Owlstone Medical Enters Partnership with Bicycle Therapeutics for the Development of Antigen-Targeted EVOC Probes for Early Cancer Detection

New CDC opioid guidelines: Too little, too late for chronic pain patients?

Bormioli Pharma North America sales grew by more than 40% in 2022

Lassa virus vaccine induces rapid protection in an animal model

Bispecific antibody shows improved efficacy against SARS-CoV-2 variants

Why does insulin cost so much? Big Pharma isn’t the only player driving prices

Statin-related residual inflammation predicts cardiovascular events and mortality

FDA mandate to limit the dosage of acetaminophen linked to reductions in serious liver injury

Decades of substantial U.S. Government investment in mRNA technology paved way for COVID-19 vaccines

Antibody levels from prime COVID-19 mRNA vaccine influences the efficacy of booster doses

Non-critically ill hospitalized Covid-19 patients could substantially benefit from a higher dose of blood-thinners

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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