Alzheimer's & Dementia News and Research

Latest Alzheimer's & Dementia News and Research

Children with epilepsy at higher risk for mood and behavior disorders

Children with epilepsy are at high risk for depression, anxiety, and behavioral functioning disorders. Mood and behavior are known to change or improve in children following epilepsy surgery, but research is inconsistent concerning the extent of the change.

9 Dec 2013

Heptares starts HTL9936 Phase 1 study for improving cognitive function in Alzheimer's patients

Heptares Therapeutics, the leading GPCR structure-guided drug discovery and development company, announces that it has initiated a Phase 1 clinical study of HTL9936, the first fully selective muscarinic M1 receptor agonist to enter clinical development. HTL9936 is an orally available, small molecule drug candidate discovered using the Heptares GPCR structure-based drug design platform.

9 Dec 2013

NYSCF, PersonalGenomes.org partner to identify genetic contributions to disease development

Today, the New York Stem Cell Foundation Research Institute and PersonalGenomes.org announced a partnership to identify genetic and environmental contributions to trait and disease development. Cell lines generated by NYSCF will complement genomic data and medical histories contributed by participants in the Harvard Personal Genome Project, creating a unique and powerful resource to help researchers identify causes of disease.

9 Dec 2013

Penn researchers identify protein that could clear Alzheimer's plaques

The body is structured to ensure that any invading organisms have a tough time reaching the brain, an organ obviously critical to survival. Known as the blood-brain barrier, cells that line the brain and spinal cord are tightly packed, making it difficult for anything besides very small molecules to cross from the bloodstream into the central nervous system. While beneficial, this blockade also stands in the way of delivering drugs intended to treat neurological disorders, such as Alzheimer's.

9 Dec 2013

Study shows VEEG telemetry monitoring with early cessation of AED therapy is safe, effective

Patients with epilepsy often undergo evaluation by concurrent video and EEG monitoring (vEEG) for therapeutic planning, including possible epilepsy surgery. Seizures during monitoring increase the diagnostic yield and requires the withdrawal of anticonvulsant drugs (AEDs) to allow seizures to occur.

9 Dec 2013

Researchers uncover biological factor that may contribute to disparities in prostate cancer incidence

Researchers have uncovered a potential biological factor that may contribute to disparities in prostate cancer incidence and mortality between African-American and non-Hispanic white men in the United States, according to results presented here at the Sixth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held Dec. 6-9.

9 Dec 2013

Research findings suggest possible novel strategies to prevent SUDEP

Patients with epilepsy and, in particular, those with severe syndromic forms of the disorder, harbor a risk of sudden unexplained death in epilepsy, or SUDEP. Cardiac arrhythmias are a proposed cause. In a test of this theory, researchers have demonstrated that mice harboring a human SCN1A gene mutation that results in Dravet Syndrome, a severe and intractable genetic epilepsy, have electrical disturbances in the heart that culminate in ventricular fibrillation and sudden cardiac death.

9 Dec 2013

Prolonged febrile seizures can affect pediatric patients

A long-standing hypothesis holds that prolonged febrile (fever induced) seizures, the most common form of childhood convulsive status epilepticus, cause mesial temporal sclerosis. CSE is a single seizure, or two or more seizures between which consciousness is not regained, lasting for more than 30 minutes.

9 Dec 2013

$Management of refractory convulsive status epilepticus varies at different medical centers$

Management of refractory convulsive status epilepticus varies at different medical centers

The management of refractory convulsive status epilepticus varies at different medical centers and from patient to patient. Rapid success in aborting these non-stop seizures is crucial as the risk of neurological damage is high and, though rare, may result in death depending on seizure duration. By pooling data and analyzing current RCSE management practices, researchers representing a multicenter network of tertiary referral hospitals in the U.S. conducted a study that could lead to improved treatment outcomes for potentially life-threatening seizures.

9 Dec 2013

Scientists identify important new genes for epilepsy

Scientists screening the DNA of large cohorts for known and suspected epilepsy associated genes are finding that, while some genes are implicated in discrete phenotypes or forms of epilepsy, other genes are implicated in a wider range of phenotypes. Although ion channel genes are a common cause of epilepsy, the researchers also report a significant number of epilepsy patients with mutations in non-ion channel genes. The studies have important implications for treatment, prognosis and risk counseling.

9 Dec 2013

Underlying loss of awareness during partial seizures is same as deep sleep

Epilepsy patients with complex partial seizures have impaired consciousness during seizure episodes and typically have no memory of the event. However, the mechanisms of seizure unconsciousness are unclear.

9 Dec 2013

Researchers investigate effect of epilepsy surgery on patients lives

Resective surgery is an effective treatment for dug-resistant epilepsy. To investigate the effect of epilepsy surgery on patients lives, researchers from the Comprehensive Epilepsy Program at the Henry Ford Hospital in Detroit conducted a long-term retrospective follow up of surgical patients and correlated post-surgical psychosocial outcomes with seizure outcome and brain area surgically treated.

9 Dec 2013

Bonn researchers use reprogrammed neurons for drug testing in Alzheimer patients

Why do certain Alzheimer medications work in animal models but not in clinical trials in humans? A research team from the University of Bonn and the biomedical enterprise LIFE & BRAIN GmbH has been able to show that results of established test methods with animal models and cell lines used up until now can hardly be translated to the processes in the human brain.

9 Dec 2013

Scientists receive 2013 Horwitz Prize for discoveries on how brain calculates location, navigation

Edvard and May-Britt Moser of the Norwegian University of Science and Technology (NTNU), and John O'Keefe, from University College London have been awarded the 2013 Louisa Gross Horwitz Prize for discoveries that have illuminated how the brain calculates location and navigation.

9 Dec 2013

Study provides possible therapeutic strategy for Alzheimer's disease via progesterone

Steroid hormones and their metabolites within the central nervous system are commonly defined as neuroactive steroids or neurosteroids. Although neuroactive steroids have been shown to improve learning and memory ability and protect against amyloid beta peptide-induced neurotoxicity, changes in their level during Alzheimer's disease and their role in Aβ-mediated cognitive impairment remain elusive given the limitation in sample sizes and analysis methods.

8 Dec 2013

ALS TDI forms research partnership with Neurimmune to advance potential treatments for ALS

The ALS Therapy Development Institute (ALS TDI), together with its wholly-owned subsidiary, Anelixis Therapeutics, announced today that it has formed a research partnership with Neurimmune to advance potential treatments for ALS, also known as Lou Gehrig's disease.

6 Dec 2013

Aortic valve implantation does not impair mental capacity of patients

Aortic valve stenosis is the most frequent heart valve defect of older people in Europe - the cause is usually increasing calcification of this important valve. In patients at high and excessive risk, conventional cardiac surgery is often no therapeutic option.

6 Dec 2013

Alzheimer's & Dementia News and Research

Latest Alzheimer's & Dementia News and Research

Children with epilepsy at higher risk for mood and behavior disorders

Heptares starts HTL9936 Phase 1 study for improving cognitive function in Alzheimer's patients

NYSCF, PersonalGenomes.org partner to identify genetic contributions to disease development

Penn researchers identify protein that could clear Alzheimer's plaques

Study shows VEEG telemetry monitoring with early cessation of AED therapy is safe, effective

Researchers uncover biological factor that may contribute to disparities in prostate cancer incidence

Research findings suggest possible novel strategies to prevent SUDEP

Prolonged febrile seizures can affect pediatric patients

Management of refractory convulsive status epilepticus varies at different medical centers

Scientists identify important new genes for epilepsy

Underlying loss of awareness during partial seizures is same as deep sleep

Researchers investigate effect of epilepsy surgery on patients lives

Bonn researchers use reprogrammed neurons for drug testing in Alzheimer patients

Scientists receive 2013 Horwitz Prize for discoveries on how brain calculates location, navigation

Study provides possible therapeutic strategy for Alzheimer's disease via progesterone

ALS TDI forms research partnership with Neurimmune to advance potential treatments for ALS

Aortic valve implantation does not impair mental capacity of patients

Eli Lilly reports edivoxetine Phase III program did not meet primary endpoint for major depressive disorder

Eisai reports new data analyses on FYCOMPA (Perampanel) at AES meeting

Scientists test affected human nerve cells to foretell efficacy of Alzheimer drugs

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

Alzheimer's & Dementia News and Research

Latest Alzheimer's & Dementia News and Research

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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