Alzheimer's & Dementia News and Research

Latest Alzheimer's & Dementia News and Research

Probiodrug secures EUR 15M for clinical development of PQ912

Probiodrug AG today announced it has secured EUR 15 million additional financing for the ongoing development of its glutaminyl cyclase (QC) inhibitor program. The lead compound, PQ912, its first QC inhibitor, is in clinical development for the treatment of Alzheimer's disease.

5 Jan 2012

Working Group recommends use of biomarkers in AD clinical trials

A group of thought leaders in Alzheimer's disease says the science is solid and the time has come for more widespread use of biomarkers in Alzheimer disease (AD) clinical trials, to speed the identification of effective disease-modifying treatments for this incurable disorder.

5 Jan 2012

UCSD scientist honored for Down syndrome research

William C. Mobley, MD, PhD, chair of the Department of Neurosciences at the University of California, San Diego School of Medicine and Chairman of the U.S. Scientific Advisory Committee of the J-r-me Lejeune Foundation, was recognized by U.S. Congressman Pete Sessions from the floor of the House of Representatives in December. Sessions said of Mobley - who received the International Sisley-J-r-me Lejeune Prize in a ceremony at the Museum of Medical History in Paris on December 8.

5 Jan 2012

Bionomics, Ironwood partner to develop and commercialize novel anti-anxiety compound

Ironwood Pharmaceuticals, Inc. and Bionomics Limited today announced that they entered into a collaboration, research, and licensing agreement that will enable Ironwood to develop and commercialize Bionomics' investigational anti-anxiety compound BNC210 and other related compounds.

5 Jan 2012

NGP receives investment from Abbott to develop NGP 555 for AD

NeuroGenetic Pharmaceuticals, Inc. (NGP), a privately held biopharmaceutical company focused on Alzheimer's disease (AD) therapeutics, has received an investment from Abbott Biotech Ventures.

5 Jan 2012

Amyloid precursor protein fragment may be a biomarker for autism

Immune system abnormalities that mimic those seen with autism spectrum disorders have been linked to the amyloid precursor protein (APP), reports a research team from the University of South Florida's Department of Psychiatry and the Silver Child Development Center.

4 Jan 2012

Genomic architecture predisposes supercentenarians to age-related diseases

The first-ever published whole-genome sequences of not just one, but two supercentenarians, aged more than 114 years, reveal that both unusual and common genetic phenomena contribute to the genetic background of extreme human longevity.

4 Jan 2012

Bingo enhances cognitive performance in people with Alzheimer's and Parkinson's disease

Bingo, a popular activity in nursing homes, senior centers and assisted-living facilities, has benefits that extend well beyond socializing. Researchers found high-contrast, large bingo cards boost thinking and playing skills for people with cognitive difficulties and visual perception problems produced by Alzheimer's disease (AD) and Parkinson's disease (PD).

4 Jan 2012

Low T Center for testosterone replacement therapy opens new clinic in Denver

Low T Center is opening a new clinic at 12213 North Pecos, Westminster, Co., a suburb of Denver on Tuesday, January 3, 2012. This men's oriented clinic will provide testosterone replacement therapy in the form of testosterone injections for men around the ages of 40-60 years old.

4 Jan 2012

Origin of osteoporosis could be directly linked to manganese depletion

The loss of manganese could mean that calcium does not stick to bones and could cause osteoporosis. This is the new theory put forward by researchers at the University of Castilla-La Mancha (UCLM) in Spain after studying deer antlers.

3 Jan 2012

Vitamins and omega 3 fatty acids in blood could stave off dementia: Study

A new study has shown that higher blood levels of omega-3 fatty acids, vitamin B, vitamin C, vitamin D and vitamin E are associated with better mental functioning in the elderly.

3 Jan 2012

Hormone Adiponectin linked to dementia in women: Study

New research has shown that there may be a possible connection between a hormone found in body fat and the risk of dementia, adding to the growing evidence on the potential link between the condition and diabetes.

3 Jan 2012

Combination of biomarkers indicates high risk of Alzheimer's in the future

Physician Oskar Hansson and his research group are studying biomarkers - substances present in spinal fluid and linked to Alzheimer's disease. The group has studied close to 140 people with mild memory impairment, showing that a certain combination of markers (low levels of the substance beta-amyloid and high levels of the substance tau) indicate a high risk of developing Alzheimer's disease in the future.

3 Jan 2012

Adiponectin may play a role in development of all-cause dementia and AD in women

A hormone derived from visceral fat called adiponectin may play a role as a risk factor for development of all-cause dementia and Alzheimer disease (AD) in women, according to a study published Online First by the Archives of Neurology, one of the JAMA/Archives journals.

3 Jan 2012

Sex, race and dementia may influence risk of mortality in patients with PD

Demographics and clinical factors appear to be associated with survival in patients with Parkinson disease (PD), and the presence of dementia is associated with a significant increase in mortality, according to a report in the January issue of Archives of Neurology, one of the JAMA/Archives journals.

2 Jan 2012

CSF Aβ42 levels appear to be decreased before patients with MCI develop AD dementia

Cerebrospinal fluid levels of Aβ42 appear to be decreased at least five to 10 years before some patients with mild cognitive impairment develop Alzheimer disease (AD) dementia whereas other spinal fluid levels seem to be later markers of disease, according to a report in the January issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

2 Jan 2012

Glia cells also regulate learning and memory

Glia cells, named for the Greek word for "glue," hold the brain's neurons together and protect the cells that determine our thoughts and behaviors, but scientists have long puzzled over their prominence in the activities of the brain dedicated to learning and memory.

30 Dec 2011

Prion protein uptake associated with development of Scrapie disease

Scrapie is a neurodegenerative disease which can function as a model for other diseases caused by an accumulation of proteins resulting in tissue malformations (proteinpathies), such as Alzheimer's and Parkinson's disease.

30 Dec 2011

Healthy diet keeps the brain sharp

The study shows that elderly who followed this diet had less of the brain shrinkage linked with Alzheimer's disease and scored better on mental and thinking tests than those with poorer diets. Although previous studies have suggested that a heart-healthy diet is also good for the brain, the new study took a different approach by using blood tests to determine the participant’s diet and nutrient levels.

29 Dec 2011

Silent strokes linked to memory loss in the elderly

New research links 'silent strokes,' or small spots of dead brain cells, found in about one out of four older adults to memory loss in the elderly. The study is published in the January 3, 2012, print issue of Neurology-, the medical journal of the American Academy of Neurology.

29 Dec 2011

Alzheimer's & Dementia News and Research

Latest Alzheimer's & Dementia News and Research

Probiodrug secures EUR 15M for clinical development of PQ912

Working Group recommends use of biomarkers in AD clinical trials

UCSD scientist honored for Down syndrome research

Bionomics, Ironwood partner to develop and commercialize novel anti-anxiety compound

NGP receives investment from Abbott to develop NGP 555 for AD

Amyloid precursor protein fragment may be a biomarker for autism

Genomic architecture predisposes supercentenarians to age-related diseases

Bingo enhances cognitive performance in people with Alzheimer's and Parkinson's disease

Low T Center for testosterone replacement therapy opens new clinic in Denver

Origin of osteoporosis could be directly linked to manganese depletion

Vitamins and omega 3 fatty acids in blood could stave off dementia: Study

Hormone Adiponectin linked to dementia in women: Study

Combination of biomarkers indicates high risk of Alzheimer's in the future

Adiponectin may play a role in development of all-cause dementia and AD in women

Sex, race and dementia may influence risk of mortality in patients with PD

CSF Aβ42 levels appear to be decreased before patients with MCI develop AD dementia

Glia cells also regulate learning and memory

Prion protein uptake associated with development of Scrapie disease

Healthy diet keeps the brain sharp

Silent strokes linked to memory loss in the elderly

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Alzheimer's & Dementia News and Research

Latest Alzheimer's & Dementia News and Research

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

Edoardo Fabini

Reducing polypharmacy through innovative drug formulation technologies

How innovation in dried blood spot testing is transforming neurological disease monitoring

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