Bipolar Disorder

Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in mood, energy, activity levels, and the ability to carry out day-to-day tasks. Symptoms of bipolar disorder are severe.

The Genetics of Mental Disorder

No psychiatric or mental disorder has a fully genetic basis or heritability, and many environmental factors may influence the likelihood of a particular disorder.

Bipolar Disorder and Parkinson’s

Bipolar Disorder Treatment

What is Schizoaffective Disorder?

Bipolar Disorder Interventions

Intermittent Explosive Disorder Causes

Generalized Anxiety Disorder Comorbidities

Bipolar Disorder

Bipolar Disorder Counseling

What is Olanzapine?

Bipolar Disorder Diagnosis

Bipolar Disorder Symptoms

Latest Bipolar Disorder News and Research

11 genetic loci that shape impulsive decision-making

Researchers identify distinct genetic loci involved in delay discounting and how these variants are involved in physical and psychiatric health outcomes.

3 Dec 2025

Hallucinogen-related hospital care linked to higher risk of future mania

People who have received emergency or hospital care in Canada due to hallucinogen use have a six-fold increased risk of receiving care for mania in the next three years, according to a study published December 2nd in the open-access journal PLOS Medicine by Daniel Myran from North York General Hospital in Canada and colleagues.

2 Dec 2025

Drinking three to four cups of coffee a day may slow cellular aging

New findings reveal that 3-4 cups of coffee daily may enhance telomere length, potentially slowing cellular aging in individuals with severe mental disorders.

28 Nov 2025

Moderate coffee intake linked to slower biological aging in people with severe mental illness

Drinking a maximum of 3-4 cups of coffee a day may slow the 'biological' ageing of people with severe mental illness, by lengthening their telomeres-indicators of cellular ageing-and giving them the equivalent of 5 extra biological years, compared with non-coffee drinkers, finds research published in the open access journal BMJ Mental Health.

25 Nov 2025

Immune system abnormalities identified as core mechanism in major depressive disorder

Major depressive disorder (MDD) is characterized by a lowered mood and loss of interest, contributing not only to difficulties in academic and professional life but also as a major cause of suicide in South Korea.

21 Nov 2025

Evaluating whether LIT supplementation slows cognitive decline in Alzheimer’s patients

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline such as memory loss and behavioral disturbances that severely impair quality of life. Despite decades of research, effective disease-modifying therapies remain elusive, underscoring the urgent need for novel neuroprotective strategies.

19 Nov 2025

Large language models revolutionize psychiatric questionnaires

Large language models can help improve questionnaires used to diagnose mental illness by optimizing symptom generalizability and reducing redundancy.

18 Nov 2025

Why early- and late-onset depression are fundamentally different

Genetic differences in early- and late-onset depression highlight distinct risk profiles, informing targeted strategies for improved clinical outcomes.

17 Nov 2025

Can creatine help with depression? New review says results are inconclusive

Creatine supplementation may modestly reduce depressive symptoms, but the effect is small, uncertain, and likely influenced by study bias. The evidence remains of very low quality, highlighting the need for larger, well-designed clinical trials.

6 Nov 2025

Researchers identify patient response patterns to novel schizophrenia medication

Each year, about 100,000 Americans experience psychosis, a serious condition that disrupts thoughts and perceptions so profoundly that it can distort a person's sense of reality.

6 Nov 2025

USC researchers map genetic architecture of the human corpus callosum

For the first time, a research team led by the Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC has mapped the genetic architecture of a crucial part of the human brain known as the corpus callosum-the thick band of nerve fibers that connects the brain's left and right hemispheres.

4 Nov 2025

International experts urge the reclassification of postpartum psychosis to improve treatment

An international panel of leading women's mental health experts – including UVA Health's Jennifer Payne, MD – is calling to reclassify postpartum psychosis as its own category of mental illness to improve the care new mothers receive.

3 Nov 2025

New $4.4 million grant funds first study of prefrontal cortical stimulation in severe bipolar disorder

A University of Minnesota Medical School research team, led by Ziad Nahas, MD, has been awarded a $4.4 million grant for a first-in-the-world study of prefrontal cortical stimulation in severe bipolar disorder.

31 Oct 2025

Low-cost biosensor identifies altered protein levels associated with psychiatric disorders

Brazilian researchers have developed a low-cost, portable biosensor that can quickly identify a protein whose altered levels are associated with psychiatric disorders, such as depression, schizophrenia, and bipolar disorder.

30 Oct 2025

Mount Sinai receives $4.5 million grant to investigate neural mechanisms underlying bipolar disorder

The Icahn School of Medicine at Mount Sinai is pleased to announce it has received a three-year, $4.5 million grant from BD2: Breakthrough Discoveries for thriving with Bipolar Disorder to investigate the neural mechanisms underlying bipolar disorder and pioneer novel neuromodulation-based treatment strategies.

28 Oct 2025

BD² expands global effort to examine the key mechanisms of bipolar disorder

Today, BD², or Breakthrough Discoveries for thriving with Bipolar Disorder, announced its third round of Discovery Research grants, totaling nearly $18 million – expanding a comprehensive global effort to examine the key mechanisms of bipolar disorder.

28 Oct 2025

Scientists uncover excessive maturation and aging in the hippocampus

In a groundbreaking study, researchers at Fujita Health University and the Tokyo Metropolitan Institute of Medical Science have uncovered a previously overlooked form of brain abnormality linked to anxiety: excessive maturation and aging in the hippocampus, a state they term "hyper-maturity."

27 Oct 2025

Ribosomal RNA found to share unique motifs with nervous system genes

Ribosomal RNA (rRNA) is a type of molecule and a key building block of the ribosome, the cell's protein-making machinery. rRNA accounts for much of the RNA in a cell, and it's crucial for life.

14 Oct 2025

Voter health trends reveal strong backing for Reform UK

Poorer health is linked to a higher proportion of votes for the populist right wing political party, Reform UK, indicates an analysis of the 2024 general election voting patterns in England, published online in the open access journal BMJ Open Respiratory Research.

14 Oct 2025

New insights can reshape psychiatric practice across continents

In a compelling Genomic Press Interview published today in Genomic Psychiatry, Dr. Bruce M. Cohen discusses results and insights that are reshaping international approaches to understanding and treating neuropsychiatric disorders.

14 Oct 2025