Chromosome News and Research

Latest Chromosome News and Research

Active nuclear deformations contribute to formation of intra-nuclear chromosome architectures

There are two types of chromatin, euchromatin and heterochromatin, that vary with the stages of the cell cycle. In particular, euchromatin with rich active genes localizes to the interior of the nucleus during interphase; heterochromatin usually localizes to the periphery of the nucleus.

20 Oct 2015

New genetic discovery could lead to better treatment for X-linked diseases

Think back to middle school biology class, when you learned that boys have an X and a Y chromosome inside each cell, and girls have two X's.

20 Oct 2015

New UCL study highlights genes associated with schizophrenia and obesity

Genes involved in schizophrenia and obesity have been highlighted in a new UCL study, which could lead to a better understanding of the DNA variants which affect risk of these conditions and aid the development of improved strategies for prevention and treatment.

18 Oct 2015

Researchers create high resolution images of telomerase that plays major role in cancer, aging

An enzyme called telomerase plays a significant role in aging and most cancers, but until recently many aspects of the enzyme's structure could not be clearly seen.

16 Oct 2015

Only few doctors refer children with developmental delays to genetics specialists, say researchers

A nine-month-old boy isn't rolling over, reaching for objects or babbling as he should be. One step his doctor won't likely take right away: have him evaluated by a genetics specialist.

15 Oct 2015

Penn researchers show that canine X-linked retinitis pigmentosa can be cured over the long term

Three years ago, a team from the University of Pennsylvania announced that they had cured X-linked retinitis pigmentosa, a blinding retinal disease, in dogs. Now they've shown that they can cure the canine disease over the long term, even when the treatment is given after half or more of the affected photoreceptor cells have been destroyed.

13 Oct 2015

YK-4-279 compound works against some forms of leukemia: Study

A compound discovered and developed by a team of Georgetown Lombardi Comprehensive Cancer Center researchers that halts cancer in animals with Ewing sarcoma and prostate cancer appears to work against some forms of leukemia, too.

12 Oct 2015

Proposed thin-plate model sheds light on structural basis of chromosomal aberrations in cancer cells

During cell division, each metaphase chromosome contains a single enormously long DNA molecule that is associated with histone proteins and forms a long chromatin filament with many nucleosomes.

9 Oct 2015

Penn study forms basis for new treatment approaches for Sezary syndrome

Sezary syndrome (SS), an aggressive leukemia of mature T cells, is more complicated at a molecular level than ever suspected, according to investigators from the Perelman School of Medicine at the University of Pennsylvania.

8 Oct 2015

SMC5/6 protein complex plays vital role in cancer suppression and premature ageing

A study conducted by the Spanish National Cancer Research Centre´s Genomic Instability Group, led by Óscar Fernández-Capetillo, describes for the first time in mammals, the role played by the SMC5/6 protein complex in cancer suppression and premature ageing. Mutations in these complexes, which were sensitive to chemotherapeutic agents, had been previously described in yeast cells, but their exact relationship with cancer or other diseases in mammals was unknown.

8 Oct 2015

Jumping genes: a marker for early cancer diagnosis? An interview with Dr Kazazian

In the genome of every human being, there are about 80-100 active LINE-1s that are capable of mobilizing by a copy and paste mechanism to a new location in the genome.

6 Oct 2015

Oxford Gene Technology launches Cytocell FISH probe for bladder cancer

Oxford Gene Technology (OGT), The Molecular Genetics Company, has launched its CE-IVD labelled Cytocell Aquarius® P16/3c/7c/17c Probe Kit, a cost-effective, ready-to-use fluorescence in situ hybridisation (FISH) probe kit for non-invasive detection of bladder cancer — for sale in Europe.

From Oxford Gene Technology 6 Oct 2015

Georgia State University researcher receives $1.35 million federal grant to study effects of emulsifiers

Andrew Gewirtz, a professor in the Institute for Biomedical Sciences at Georgia State University, has received a four-year, $1.35 million federal grant to study how emulsifiers affect bacteria in the intestinal tract and cause chronic inflammatory diseases in the gut.

6 Oct 2015

Chromosome 3q26.2 rearrangements linked to poor CML prognosis

Rearrangements of chromosome 3q26.2 have a significant negative impact on patients with chronic myeloid leukaemia, suggests research published in Blood.

1 Oct 2015

Intratumoral morphological diversity of breast cancer not related to chromosome aberrations

Intratumor morphological heterogeneity (diversity) of breast cancer is not related to chromosome aberrations. This conclusion was made based on the study of one case with aggressive variant of breast cancer - invasive micropapillary carcinoma by researchers from Tomsk State University, Tomsk Cancer Research Institute, and Institute of Medical Genetics.

30 Sep 2015

New report implicates five genetic regions that play major roles in CF disease severity

If you have two faulty copies of the CFTR gene, you will have cystic fibrosis. But the severity of your disease will depend on environmental factors and many other genes. Locating these genes and altering their function could lead to new therapies.

29 Sep 2015

ADHD children and their mothers more likely to have shorter telomeres, say Brazilian scientists

Psychiatric disorders like Attention Deficit Hyperactive Disorder (ADHD) impact family's emotions and social life. It is well known. What is new is that this condition also affects the DNA of patients and their parents.

28 Sep 2015

UK Biobank genetic study shows link between lung disease and smoking behaviour

New research published in The Lancet Respiratory Medicine and presented at this year's European Respiratory Society meeting in Amsterdam presents the first analyses of genetic data from the UK Biobank that reveal new associations with lung disease and smoking behaviour.

28 Sep 2015

Researchers find mutated gene responsible for cardiac angiosarcoma in two brothers

A few years ago, Javier Benítez, director of the Human Genetics Group at the CNIO, received a call from Pablo García Pavía, from the Cardiology Unit of the Puerta de Hierro University Hospital. This cardiologist was treating two brothers with a rare form of cancer, cardiac angiosarcoma (CAS).

26 Sep 2015

Amgen gets positive CHMP opinions for Kyprolis (carfilzomib) and BLINCYTO (blinatumomab)

"We are pleased to receive positive CHMP opinions for Kyprolis and BLINCYTO as this is an important step in providing new treatment options for patients in Europe with rare forms of cancer," said Sean E. Harper, M.D., executive vice president of Research and Development at Amgen.

25 Sep 2015

Chromosome News and Research

Latest Chromosome News and Research

Active nuclear deformations contribute to formation of intra-nuclear chromosome architectures

New genetic discovery could lead to better treatment for X-linked diseases

New UCL study highlights genes associated with schizophrenia and obesity

Researchers create high resolution images of telomerase that plays major role in cancer, aging

Only few doctors refer children with developmental delays to genetics specialists, say researchers

Penn researchers show that canine X-linked retinitis pigmentosa can be cured over the long term

YK-4-279 compound works against some forms of leukemia: Study

Proposed thin-plate model sheds light on structural basis of chromosomal aberrations in cancer cells

Penn study forms basis for new treatment approaches for Sezary syndrome

SMC5/6 protein complex plays vital role in cancer suppression and premature ageing

Jumping genes: a marker for early cancer diagnosis? An interview with Dr Kazazian

Oxford Gene Technology launches Cytocell FISH probe for bladder cancer

Georgia State University researcher receives $1.35 million federal grant to study effects of emulsifiers

Chromosome 3q26.2 rearrangements linked to poor CML prognosis

Intratumoral morphological diversity of breast cancer not related to chromosome aberrations

New report implicates five genetic regions that play major roles in CF disease severity

ADHD children and their mothers more likely to have shorter telomeres, say Brazilian scientists

UK Biobank genetic study shows link between lung disease and smoking behaviour

Researchers find mutated gene responsible for cardiac angiosarcoma in two brothers

Amgen gets positive CHMP opinions for Kyprolis (carfilzomib) and BLINCYTO (blinatumomab)

Forensics and toxicology - Industry Focus eBook eBook

From street to lab: Advancing controlled substance testing with handheld Raman and FTIR

Reimagining light scattering for biotherapeutics

Empowering genomics research with cloud-based innovation

Chromosome News and Research

Latest Chromosome News and Research

Forensics and toxicology - Industry Focus eBook eBook

From street to lab: Advancing controlled substance testing with handheld Raman and FTIR

Reimagining light scattering for biotherapeutics

Empowering genomics research with cloud-based innovation

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