Colorectal Cancer

Colorectal Cancer is cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine before the anus). In the United States, it is the fourth most common cancer in men and women. Caught early, it is often curable.

What Causes Colorectal Cancer?

Cancer occurs when a normal cell divides and multiples uncontrollably. Normally cells are regulated in their growth, maturity, division and death by the DNA present in their nucleus. With damage to the DNA the cells may become rogue and multiply uncontrollably to give rise to tumors.

Colorectal Cancer Prognosis

Microbial Dysbiosis and Colorectal Cancer

Colorectal Cancer Diagnosis

Colorectal Cancer and Organ Preservation

What is Colorectal Cancer?

Colorectal Cancer Management

Colorectal Cancer Prevention

Colorectal Cancer Symptoms

Colorectal Cancer Pathogenesis

Latest Colorectal Cancer News and Research

Using AI to enhance the design of nanoparticles for RNA therapies

Using artificial intelligence, MIT researchers have come up with a new way to design nanoparticles that can more efficiently deliver RNA vaccines and other types of RNA therapies.

18 Aug 2025

Study finds vegetarians less likely to develop several common and rare cancers

A large North American cohort study found that vegetarian diets were linked to lower risks of several cancers, including colorectal, stomach, breast, prostate, and lymphoproliferative cancers. No evidence suggested that vegetarian eating increased cancer risk for any site.

14 Aug 2025

Microbial DNA signature in the blood differentiates primary liver cancer from metastatic colorectal cancer

Determining whether a cancerous tumor originated in a given location or spread there from another tissue or organ in the body is important when assessing the likely course of a patient's disease.

14 Aug 2025

Colorectal cancer rates nearly triple among younger people in Sweden

According to a study by Karolinska Institutet, nearly three times as many people under the age of 50 in Sweden are diagnosed with colorectal cancer today compared with the early 1990s.

14 Aug 2025

Nudibranchs (sea slugs) emerge as a promising source of cancer drugs

Researchers reviewed the antitumor potential of bioactive compounds from nudibranchs, marine mollusks that acquire or synthesize potent chemical defenses. These compounds, often sourced from their diet, show promising cancer-fighting activity through mechanisms like DNA damage, oxidative stress, and apoptosis.

12 Aug 2025

Novel vaccine shows promise against KRAS-driven pancreatic and colorectal cancers

A novel cancer vaccine that stimulates the immune system to target one of the most common cancer-driving mutations has shown encouraging early results in patients with pancreatic and colorectal cancer, two of the most difficult-to-treat malignancies, according to a study led in part by investigators at the UCLA Health Jonsson Comprehensive Cancer Center.

12 Aug 2025

Genetic testing can guide safer chemotherapy for gastrointestinal cancer patients

For some patients with gastrointestinal (GI) cancers like colorectal and pancreatic cancer, chemotherapy can cause severe, sometimes life-threatening side effects in those who carry certain genetic variants that can impact how their bodies process the drugs used to treat their disease.

7 Aug 2025

Early screening linked to spike in early-stage colon cancer diagnoses

Recent study shows a significant increase in early-stage colorectal cancer among 45-49 year-olds, linked to new screening recommendations and pandemic effects.

7 Aug 2025

HOXB13 emerges as a context-dependent regulator in cancer biology

HOXB13, a B-class homeobox transcription factor, sits at the hub of developmental gene networks yet has emerged as a double-edged sword in human cancer.

5 Aug 2025

Mailing at-home test boosts colorectal cancer screening in adults under 50

In a new study aimed at identifying the best approach to promote colorectal cancer screening in adults ages 45 to 49, UCLA researchers found that simply mailing a stool-based test directly to people's homes was the most effective strategy for increasing screening rates.

4 Aug 2025

Mouth and gut microbes talk to each other - here’s why it matters for disease

Researchers reviewed nearly 250 studies to uncover how the oral and gut microbiomes communicate through multiple pathways, influencing the risk of diseases such as IBD, colorectal cancer, and cardiovascular disorders. The review highlights that maintaining oral health and dietary habits is crucial for overall systemic wellbeing.

4 Aug 2025

Novel insights from lymphoid structures: Lessons from colorectal cancer research

Discover how lymphoid structures and germinal centers provide powerful prognostic insights into colorectal cancer.

From TissueGnostics 31 Jul 2025

Harnessing the power of gut bacteria to enhance cancer immunotherapy effectiveness

A comprehensive new review reveals both the promise and challenges of using fecal microbiota transplantation (FMT) to enhance cancer immunotherapy effectiveness.

30 Jul 2025

Study identifies risk factors for second colorectal cancer in people with Lynch syndrome

A current study by the German Familial Colorectal Cancer Consortium is looking at the question of which people with Lynch syndrome are at an increased risk of developing a second colorectal cancer.

30 Jul 2025

Blood-based tests show promise for colorectal cancer screening but follow-up challenges persist

A study led by investigators at the UCLA Health Jonsson Comprehensive Cancer Center found that while blood-based tests offer a more convenient option for colorectal cancer screening, only 49% of patients completed a follow-up colonoscopy within six months, and just 56% did so at any point during the two-year study period.

29 Jul 2025

Most dairy foods linked to neutral or better health but yogurt stands out for real benefits

A major scoping review of recent systematic reviews and meta-analyses finds that most dairy products are either neutral or modestly protective for heart, cancer, metabolic, and mortality outcomes in adults. Yogurt and other fermented dairy consistently show the strongest health associations, while some risks remain for specific cancers.

28 Jul 2025

Advancing precision medicine in colorectal cancer with multi-omics approaches

Colorectal cancer is among the most prevalent and lethal malignancies worldwide, with liver metastases occurring in nearly one-third of patients and accounting for a major share of cancer-related deaths.

28 Jul 2025

Blocking a single gene disrupts vitamin D metabolism and cancer pathways in new cell study

Researchers identified SDR42E1 as a key regulator of vitamin D absorption and sterol metabolism in colorectal cancer cells. Disruption of this enzyme altered cancer-related pathways and cell viability, highlighting its potential as a therapeutic target.

21 Jul 2025

Rare coexistence of APC and KRAS mutations observed in patient with FAP and endometrial cancer

Researchers have discovered an unusual case where two well-known cancer-related mutations-APC and KRAS-coexisted in a woman with familial adenomatous polyposis (FAP) and a history of endometrial cancer.

18 Jul 2025

Study reveals complex patterns of burden and survival among people with digestive system cancers in China

Digestive system malignancies (DSMTs)-including esophageal, gastric, colorectal, liver, and pancreatic cancers-represent a major public health challenge in China.

18 Jul 2025

Colorectal Cancer

Overview

Colorectal Cancer Prognosis

Microbial Dysbiosis and Colorectal Cancer

Colorectal Cancer Diagnosis

Feature Articles

Colorectal Cancer and Organ Preservation

What is Colorectal Cancer?

Colorectal Cancer Management

Colorectal Cancer Prevention

Colorectal Cancer Symptoms

Colorectal Cancer Pathogenesis

Latest Colorectal Cancer News and Research

Using AI to enhance the design of nanoparticles for RNA therapies

Study finds vegetarians less likely to develop several common and rare cancers

Microbial DNA signature in the blood differentiates primary liver cancer from metastatic colorectal cancer

Colorectal cancer rates nearly triple among younger people in Sweden

Nudibranchs (sea slugs) emerge as a promising source of cancer drugs

Novel vaccine shows promise against KRAS-driven pancreatic and colorectal cancers

Genetic testing can guide safer chemotherapy for gastrointestinal cancer patients

Early screening linked to spike in early-stage colon cancer diagnoses

HOXB13 emerges as a context-dependent regulator in cancer biology

Mailing at-home test boosts colorectal cancer screening in adults under 50

Mouth and gut microbes talk to each other - here’s why it matters for disease

Novel insights from lymphoid structures: Lessons from colorectal cancer research

Harnessing the power of gut bacteria to enhance cancer immunotherapy effectiveness

Study identifies risk factors for second colorectal cancer in people with Lynch syndrome

Blood-based tests show promise for colorectal cancer screening but follow-up challenges persist

Most dairy foods linked to neutral or better health but yogurt stands out for real benefits

Advancing precision medicine in colorectal cancer with multi-omics approaches

Blocking a single gene disrupts vitamin D metabolism and cancer pathways in new cell study

Rare coexistence of APC and KRAS mutations observed in patient with FAP and endometrial cancer

Study reveals complex patterns of burden and survival among people with digestive system cancers in China

Industry Focus eBook: Oncology eBook

Todd Bauman and Chris Povich

Scaling organ‑chip technology for human‑relevant drug discovery

Unlocking drug amorphization: Continuous, solvent-free twin screw granulation

Colorectal Cancer

Overview

Feature Articles

Colorectal Cancer and Organ Preservation

What is Colorectal Cancer?

Colorectal Cancer Management

Colorectal Cancer Prevention

Colorectal Cancer Symptoms

Colorectal Cancer Pathogenesis

Latest Colorectal Cancer News and Research

Industry Focus eBook: Oncology eBook

Todd Bauman and Chris Povich

Scaling organ‑chip technology for human‑relevant drug discovery

Unlocking drug amorphization: Continuous, solvent-free twin screw granulation

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