Colorectal Cancer

Colorectal Cancer is cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine before the anus). In the United States, it is the fourth most common cancer in men and women. Caught early, it is often curable.

What Causes Colorectal Cancer?

Cancer occurs when a normal cell divides and multiples uncontrollably. Normally cells are regulated in their growth, maturity, division and death by the DNA present in their nucleus. With damage to the DNA the cells may become rogue and multiply uncontrollably to give rise to tumors.

What is Colorectal Cancer?

Colorectal Cancer Diagnosis

Colorectal Cancer Prevention

Colorectal Cancer Management

Colorectal Cancer Prognosis

Colorectal Cancer Symptoms

Colorectal Cancer Pathogenesis

Microbial Dysbiosis and Colorectal Cancer

Colorectal Cancer and Organ Preservation

Latest Colorectal Cancer News and Research

Noninvasive home test significantly cuts colorectal cancer mortality

A noninvasive colorectal cancer screening test that can be done at home could reduce the risk of colorectal cancer death by 33%, according to a new study published in JAMA Network Open.

25 Jul 2024

MD Anderson and Summit Therapeutics partner to accelerate ivonescimab development

The University of Texas MD Anderson Cancer Center and Summit Therapeutics, Inc. today announced a strategic five-year collaboration agreement for the purpose of accelerating the development of ivonescimab.

25 Jul 2024

Reducing testing disparities could dramatically cut colon cancer rates among Black Americans

A new paper in the Journal of the National Cancer Institute, published by Oxford University Press, finds that eliminating the race disparity in colon cancer testing in the United States would reduce colon cancer, and colon cancer death rates, dramatically among Black people.

24 Jul 2024

Study unveils key mechanisms behind colorectal cancer metastasis to the liver

In cases where cancer is fatal, nine out of ten times the culprit is metastasis.

24 Jul 2024

Oral-gut axis: How mouth bacteria impact your overall health

A recent review in Nature Reviews Microbiology highlights how oral and gut microbiomes interact, impacting overall human health. Oral microorganisms can enter the gut, contributing to dysbiosis and various diseases, necessitating further research on these complex interactions.

24 Jul 2024

Research may pave the way for systemic targeted therapy for patients with pseudomyxoma peritonei

Published in Clinical Cancer Research, results of a preclinical study led by investigators of the Vall d'Hebron Institute of Oncology's (VHIO) Stem Cells and Cancer Group, headed by Héctor G. Palmer, pave the way for systemic targeted therapy in patients with pseudomyxoma peritonei, a rare form of cancer with very few therapeutic options available.

19 Jul 2024

Western diets linked to increased risk of IBD and colorectal cancer

Western diets pose a greater risk of Inflammatory Bowel Disease (IBD) and colorectal cancer, according to a milestone review of what people eat around the world.

18 Jul 2024

CU Boulder research uncovers role of endogenous retroviruses in cancer

Peek inside the human genome and, among the 20,000 or so genes that serve as building blocks of life, you'll also find flecks of DNA left behind by viruses that infected primate ancestors tens of millions of years ago.

18 Jul 2024

Out-of-pocket costs from diagnostic testing after prostate cancer screening are common and rising

Prostate-specific antigen (PSA) screening aims to identify men who may harbor potentially lethal prostate cancer, and those with high PSA results often require more extensive (and expensive) diagnostic testing to establish a diagnosis.

15 Jul 2024

40% of US cancer cases linked to lifestyle choices

Nearly 40% of cancer cases and 44% of cancer deaths in 2019 were due to modifiable risk factors, with cigarette smoking as the leading cause. This study highlights the potential to significantly reduce cancer burden through lifestyle changes.

14 Jul 2024

Mainz Biomed seeks FDA’s Breakthrough Devices Designation for advanced colorectal cancer test

Mainz Biomed N.V., a molecular genetics diagnostic company specializing in the early detection of cancer, announced that it has submitted its application to the U.S. Food and Drug Administration (FDA) requesting Breakthrough Device Designation for its non-invasive Next Generation colorectal cancer (CRC) product including the Company’s novel portfolio of mRNA biomarkers. Subject to the FDA’s review, a Breakthrough Device Designation could significantly accelerate approval.

13 Jul 2024

Optical metabolic imaging reveals how Toxoplasma infection changes host cell metabolism

Toxoplasma gondii is a parasite responsible for toxoplasmosis, a lifelong chronic infection prevalent in about 30% of the human population.

12 Jul 2024

Cellular immunotherapy offers hope for solid tumors

Early findings from a small clinical trial provide evidence that a new cellular immunotherapy approach may be effective in treating metastatic solid tumors. In the trial, researchers from the National Institutes of Health (NIH) genetically engineered normal white blood cells, known as lymphocytes, from each patient to produce receptors that recognize and attack their specific cancer cells.

12 Jul 2024

Study: 40% of cancer cases in the U.S. attributable to modifiable risk factors

A new study led by researchers at the American Cancer Society (ACS) finds four in 10 cancer cases and about one-half of all cancer deaths in adults 30 years old and older in the United States (or 713,340 cancer cases and 262,120 cancer deaths in 2019) could be attributed to modifiable risk factors, including cigarette smoking, excess body weight, alcohol consumption, physical inactivity, diet, and infections.

11 Jul 2024

Gut Blastocystis linked to healthier diets and better heart health, study finds

Intestinal Blastocystis is linked to healthier diets and improved cardiometabolic outcomes, suggesting its beneficial role in human health. This global study highlights the potential of personalized nutrition based on gut microbiome composition.

10 Jul 2024

GLP-1 drugs found to lower cancer risk in diabetes patients

Research finds that GLP-1 receptor agonists significantly reduce the risk of 10 out of 13 obesity-associated cancers in type 2 diabetes patients compared to insulins, but show varied results against metformin.

8 Jul 2024

Reducing processed meat consumption could reduce burden of chronic diseases in the USA, study suggests

Researchers developed a microsimulation model, micro-Simulation of the Health Impacts of Food Transformations, to evaluate the impact of reducing processed and unprocessed meat intake on cardiovascular disease, diabetes mellitus type 2, colorectal cancers, and death rates in the US.

8 Jul 2024

Study reveals health benefits of reducing processed meat consumption

Reducing consumption of processed meat by around one-third could prevent more than 350,000 cases of diabetes in the US over 10 years, a study suggests.

3 Jul 2024

Microscopic changes in the liver can be used to predict pancreatic cancer spread

Microscopic changes in the liver can be used to predict if, and where, pancreatic cancer may spread in the body.

28 Jun 2024

Using liver biopsies to identify predictors of pancreatic cancer metastasis

Researchers at Weill Cornell Medicine with an international team have used liver biopsies to identify cellular and molecular markers that can potentially be used to predict whether and when pancreatic cancer will spread to an individual's liver or elsewhere, such as the lung.

28 Jun 2024