Colorectal Cancer

Colorectal Cancer is cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine before the anus). In the United States, it is the fourth most common cancer in men and women. Caught early, it is often curable.

What Causes Colorectal Cancer?

Cancer occurs when a normal cell divides and multiples uncontrollably. Normally cells are regulated in their growth, maturity, division and death by the DNA present in their nucleus. With damage to the DNA the cells may become rogue and multiply uncontrollably to give rise to tumors.

What is Colorectal Cancer?

Colorectal Cancer Diagnosis

Colorectal Cancer Prevention

Colorectal Cancer Management

Colorectal Cancer Prognosis

Colorectal Cancer Symptoms

Colorectal Cancer Pathogenesis

Microbial Dysbiosis and Colorectal Cancer

Colorectal Cancer and Organ Preservation

Latest Colorectal Cancer News and Research

Cleveland Clinic study reveals insights on immune checkpoint inhibitors for colorectal cancer

A team of researchers from Cleveland Clinic Genomic Medicine share insights from an early set of 19,000 patients to receive immune checkpoint inhibitor treatments for colorectal cancer in the U.S.

20 Mar 2025

Scientists identify top food sources of prebiotics for better digestion

Researchers quantified prebiotic levels in 35 common foods and estimated daily intake in Italians, finding cereal products and legumes as the richest sources.

20 Mar 2025

Colorectal cancer patients face increased risk of cardiovascular death

People diagnosed with colorectal cancer are significantly more likely to die of cardiovascular causes than the general population, especially in the first two years after their cancer diagnosis and in people younger than 50, according to a study being presented at the American College of Cardiology's Annual Scientific Session (ACC.25).

20 Mar 2025

AGA issues new recommendations on AI-assisted colonoscopy technology

The American Gastroenterological Association (AGA) released a new clinical guideline making no recommendation - for or against - the use of computer-aided detection systems (CADe) in colonoscopy.

20 Mar 2025

Eating by the book: French dietary guidelines linked to lower mortality risk

Higher adherence to the 2017 French dietary guidelines is linked to lower mortality risk, particularly for cardiovascular and some cancer deaths, though lung cancer risk trends reversed at high adherence levels.

17 Mar 2025

ASCOLT trial explores aspirin’s role in preventing colorectal cancer recurrence

A large-scale, international, multicentre, phase 3 clinical trial of aspirin for the secondary prevention of colorectal cancer has concluded.

17 Mar 2025

Pitt study uncovers a novel trigger of deadly form of ovarian cancer

Researchers at the University of Pittsburgh have identified a novel trigger of a deadly form of ovarian cancer: a subset of progenitor cells that reside in fallopian tube supportive tissue, or stroma.

14 Mar 2025

Proteins identified as key players in immunotherapy resistance for colorectal cancer

A discovery by Mayo Clinic researchers may help explain why immunotherapy hasn't been helpful for many patients with metastatic colorectal cancer.

13 Mar 2025

Impact of excessive alcohol consumption on digestive health

Excessive alcohol consumption is a significant public health concern, responsible for approximately 6% of all deaths and contributing to 5.1% of the global disease burden.

12 Mar 2025

Breast cancer deaths expected to fall in the EU and UK by 2025 across most age groups

Death rates from breast cancer will fall in 2025 in every age group in the EU and the UK apart from in EU patients aged 80 years and older. In these older patients, overall mortality rates from the disease are predicted to rise by nearly 10% in 2025.

12 Mar 2025

Emergency room downtime can boost cervical cancer screenings, study shows

A University of Rochester Medical Center study showed that downtime in the emergency room can have a potential upside for women who are behind on cervical cancer screenings, which is a nationwide problem.

11 Mar 2025

Novel regulators in digestive tract disease progression and treatment

This new article published in Genes & Diseases highlights the critical role of tRNA-derived small RNAs (tsRNAs) in digestive tract diseases, positioning these molecules as potential biomarkers for diagnosis, prognosis, and targeted therapies. The comprehensive review explores the biogenesis, classification, and biological functions of tsRNAs, shedding light on their influence over cellular processes such as translation regulation, epigenetic modification, and protein interactions.

11 Mar 2025

Study highlights the role of ELF4 as a key transcription factor in development, immunity, and oncology

ELF4, a transcription factor belonging to the ETS family, has emerged as a pivotal regulator in cell differentiation, immune system function, and cancer progression. This newly published review underscores its molecular complexity and clinical significance, shedding light on its dual role in tumor suppression and oncogenesis.

11 Mar 2025

Is red meat good or bad for you? Study explains how amino acids shape the answer

Researchers at Texas Tech University reviewed how red meat proteins and amino acids affect human health, weighing both benefits and risks. Their findings highlight that while red meat provides vital nutrients, overconsumption and poor preparation methods can increase disease risk.

10 Mar 2025

Circular RNA plays key role in cancer biology and therapy

A new review article highlights the transformative role of circular RNA (circRNA) in cancer, revealing its potential as both a key player in tumor biology and a promising avenue for future therapies.

8 Mar 2025

Global study finds fruit and vegetable consumption cuts disease risk—why aren't we eating enough?

Scientists confirm fruits and vegetables reduce diabetes, heart disease risk, but highlight urgent need for clarity on cancer protection mechanisms. Sustainable water practices and targeted policy actions are crucial for wider adoption.

6 Mar 2025

Eating ultra-processed foods harms your gut—here’s how inflammation takes hold

Ultra-processed foods disrupt gut microbiome balance, causing inflammation, reduced microbial diversity, and increased gut permeability. This microbiome imbalance contributes to chronic diseases including diabetes, IBD, cancer, and neurological disorders.

6 Mar 2025

New guidelines for optimizing bowel preparation in colonoscopy procedures

Updated consensus recommendations by the U.S. Multi-Society Task Force on Colorectal Cancer (MSTFCRC) address optimizing the quality of bowel preparation for colonoscopy.

5 Mar 2025

Co-occurring mutations may limit effectiveness of KRAS G12C inhibitors in colorectal and pancreatic cancer

Colorectal cancer and pancreatic ductal adenocarcinoma that harbored the KRAS G12C mutation often carried other genetic alterations that can be associated with resistance to KRAS G12C inhibitors, despite no prior treatment with this therapy, according to recent results from a large multidatabase analysis.

3 Mar 2025

AI detects colorectal cancer with high accuracy

A new AI-based tool for identifying colorectal cancer from tissue sample analysis has been developed at the University of Jyväskylä. The new artificial neural network model has surpassed all its predecessors in classification performance. The tool has also been made freely available.

28 Feb 2025