Colorectal Cancer

Colorectal Cancer is cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine before the anus). In the United States, it is the fourth most common cancer in men and women. Caught early, it is often curable.

What Causes Colorectal Cancer?

Cancer occurs when a normal cell divides and multiples uncontrollably. Normally cells are regulated in their growth, maturity, division and death by the DNA present in their nucleus. With damage to the DNA the cells may become rogue and multiply uncontrollably to give rise to tumors.

Microbial Dysbiosis and Colorectal Cancer

What is Colorectal Cancer?

Colorectal Cancer Management

Colorectal Cancer Prognosis

Colorectal Cancer Symptoms

Colorectal Cancer Diagnosis

Colorectal Cancer and Organ Preservation

Colorectal Cancer Prevention

Colorectal Cancer Pathogenesis

Latest Colorectal Cancer News and Research

Six-gene signature predicts colorectal cancer recurrence after liver metastases

Researchers at The University of Texas MD Anderson Cancer Center identified a six-gene signature in microscopic colorectal cancer (CRC) liver metastases that may help predict recurrence after treatment.

9 Jul 2026

Nine gut bacteria linked to future type 2 diabetes risk

Research identifies specific gut microbes associated with future type 2 diabetes risk, emphasizing the impact of dietary fiber on microbiome health.

9 Jul 2026

Sexual and gender minority populations are less likely to receive cancer screening

A study reveals significant disparities in cancer screening rates among sexual and gender minorities, highlighting the need for equitable healthcare access.

8 Jul 2026

Yogurt, prebiotics, and probiotics link to lower colorectal cancer odds in U.S. adults

A national NHANES analysis of 9,405 U.S. adults aged 50 and older found that any yogurt, prebiotic, or probiotic consumption was associated with about 50% lower odds of self-reported colorectal cancer. Because the study was cross-sectional, it cannot prove causation but supports further research into microbiota-targeted dietary strategies.

8 Jul 2026

Microbiome science merges with oncology for better cancer treatments

Cancer remains notoriously difficult to treat, partly because tumors co‑opt their surrounding environment, including the resident microbiota, to evade immune surveillance and resist conventional therapies.

7 Jul 2026

Persistent disparities found in preventive cancer care for sexual and gender minority populations

New research has uncovered persistent disparities in preventive cancer care across different sexual orientation and gender identity (SOGI) populations.

6 Jul 2026

New study highlights noninvasive biomarkers for colorectal cancer detection

Emerging discoveries in liquid biomarker research promise to transform early detection, diagnosis, and treatment monitoring of colorectal cancer (CRC), according to a new study, offering less invasive alternatives to traditional methods that often require surgical interventions or tissue biopsies.

6 Jul 2026

Allergies show a small but significant link to later cancer risk

A systematic review and meta-analysis of 28 cohort-based studies found a weak but statistically significant association between allergic diseases and later cancer incidence. The signal was strongest in the Western Pacific region and among people with asthma, but high heterogeneity and limited subgroup evidence mean the findings require caution.

5 Jul 2026

Blood test may predict which colorectal cancer patients benefit from chemotherapy

A blood test may help identify which patients with colorectal cancer that has spread to the liver are most likely to benefit from chemotherapy after surgery, according to research presented today at the ESMO Gastrointestinal Cancers Congress 2026.

3 Jul 2026

Feeder-free TIL expansion system makes advanced cancer immunotherapy safer

Conventional TIL therapy, clinically validatedrecently with the U.S. Food and Drug Administration approval of lifileucel for advanced melanoma,stillfaces substantial hurdles.

3 Jul 2026

Fatty liver disease fuels aggressive metastatic colorectal cancer spread

Researchers at VIB and KU Leuven, with international partners, have uncovered how fatty liver disease can fuel the most aggressive form of metastatic colorectal cancer.

1 Jul 2026

German study identifies therapeutic Achilles' heel for advanced colorectal cancer

A team led by researchers from the German Cancer Research Center (DKFZ) and the HI-STEM* Stem Cell Institute has discovered a promising new approach to treating advanced colorectal cancer.

1 Jul 2026

New AI framework outperforms conventional biomarkers in predicting cancer survival

Digestive system cancers, including hepatobiliary and gastrointestinal malignancies, remain a major global oncological burden. Although immune checkpoint inhibitors have changed the treatment landscape for some patients, their overall efficacy remains limited, with only about 15% to 30% of patients achieving durable clinical benefit.

1 Jul 2026

AI and multiomics reveal how gut bacteria trigger colon cancer

Over the past two decades, high‑throughput sequencing has dramatically expanded our understanding of the gut microbiome's composition.

26 Jun 2026

Could your birth characteristics influence colorectal cancer risk?

A California study links birth and parental factors to early-onset colorectal cancer risk, highlighting male sex and Hispanic ethnicity as key contributors.

26 Jun 2026

Scientists find a universal gut microbiome pattern linked to colorectal cancer

Researchers analyzed 6,779 stool microbiome profiles and 906 tissue samples to identify a colorectal cancer microbial signature that remained consistent across age groups, populations, and sequencing methods. The signature aligned with tumor-resident microbes, showed weaker detection for adenomas, and was inversely associated with dietary fiber intake.

25 Jun 2026