Colorectal Cancer

Colorectal Cancer is cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine before the anus). In the United States, it is the fourth most common cancer in men and women. Caught early, it is often curable.

What Causes Colorectal Cancer?

Cancer occurs when a normal cell divides and multiples uncontrollably. Normally cells are regulated in their growth, maturity, division and death by the DNA present in their nucleus. With damage to the DNA the cells may become rogue and multiply uncontrollably to give rise to tumors.

Colorectal Cancer Prevention

Microbial Dysbiosis and Colorectal Cancer

Colorectal Cancer and Organ Preservation

Colorectal Cancer Diagnosis

What is Colorectal Cancer?

Colorectal Cancer Pathogenesis

Colorectal Cancer Management

Colorectal Cancer Symptoms

Colorectal Cancer Prognosis

Latest Colorectal Cancer News and Research

Study reveals unequal burden of sudden cardiac death among colorectal cancer survivors

A new research paper was published in Volume 12 of Oncoscience on November 7, 2025, titled "Temporal trends and disparities in sudden cardiac death among colorectal cancer patients: A nationwide study."

4 Dec 2025

AR3-based optogenetic strategy shows high efficacy in inducing apoptosis and antitumor effects

One of the hallmarks of cancer cells is their ability to evade apoptosis, or programmed cell death, through changes in protein expression.

2 Dec 2025

Generative AI aids discovery of ISM3830's novel scaffold

Casitas B-lineage lymphoma-b (CBLB) is an E3 ubiquitin–protein ligase that functions as an intracellular checkpoint and master negative regulator of T‑cell and natural killer (NK) cell activation, playing a central role in modulating T-cell activation and immune tolerance, and its inhibition enhances T cells and NK cells function, also provides a strategy for the function restoration of exhausted T cells.

1 Dec 2025

Epigenetic drift explains why the aging intestine becomes more vulnerable to cancer

Researchers from the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena, Germany, the Molecular Biotechnology Centre (MBC) in Turin and the University of Turin, Italy, have discovered a fundamental mechanism of aging in the gut.

28 Nov 2025

How the gut microbiome links obesity to colorectal cancer

The gut microbiome serves as both a biomarker and therapeutic target in diseases like obesity, metabolic syndrome, and colorectal cancer.

28 Nov 2025

Music therapy speeds anesthesia recovery in colorectal surgery

Integrating music therapy with anesthesia recovery care enhances recovery in colorectal cancer patients, reducing complications and stabilizing vital signs.

28 Nov 2025

Study shows one in ten young cancer patients develop metastatic recurrence

A new study of adolescents and young adults (AYAs) with seven common cancers reveals that nearly one in ten patients diagnosed with non-metastatic disease later develop metastatic recurrence - a condition associated with significantly worse survival outcomes.

26 Nov 2025

Study overturns assumptions about PTPN22 risk gene’s role in interferon production

A new paper from the University of Kansas overturns the idea that a "risk gene" carried by millions of people worldwide influences production of Type 1 interferon, a workhorse of the immune system.

25 Nov 2025

Research links social determinants of health to rural-urban disparities in colorectal cancer mortality rates

New research reveals that certain social determinants of health-such as socioeconomic status, household characteristics, and racial/ethnic minority status-have significant effects on rural–urban disparities in colorectal cancer mortality rates.

24 Nov 2025

Experts launch digital hub to transform bowel cancer prevention and care

World-leading experts have launched an online platform to enable the public to shape the future of bowel cancer research and patient care.

22 Nov 2025

Marine bacterium shows powerful therapeutic effects against colorectal cancer

A research team led by Professor Eijiro Miyako at the Graduate School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology (JAIST), has discovered that the marine bacterium Photobacterium angustum demonstrates remarkable therapeutic efficacy against colorectal cancer.

21 Nov 2025

US cancer registries, constrained by Trump policies, to recognize only ‘male’ or ‘female’ patients

The top authorities of U.S. cancer statistics will soon have to classify the sex of patients strictly as male, female, or unknown, a change scientists and advocates say will harm the health of transgender people, one of the nation's most marginalized populations.

21 Nov 2025

Oral microsphere pills can detect markers of gastrointestinal disease

Move over, colonoscopies - researchers report in ACS Sensors that they've developed a sensor made of tiny microspheres packed with blood-sensing bacteria that detect markers of gastrointestinal disease.

19 Nov 2025

Study finds low uptake of colorectal cancer testing among adults aged 45 to 49

UCLA research finds that fewer than 1 in 4 eligible younger adults completed colorectal cancer screenings after the United States Preventive Services Task Force (USPSTF) lowered the recommended screening age to 45 from 50.

18 Nov 2025

Unexpected traces of bacteria found within brain tumors

Researchers at The University of Texas MD Anderson Cancer Center have uncovered unexpected traces of bacteria within brain tumors.

14 Nov 2025

Transforming colorectal cancer research with patient-derived xenograft models

Patient-derived xenograft (PDX) models are emerging as a transformative tool in colorectal cancer (CRC) research, offering unparalleled insights into tumor biology, drug resistance, and personalized treatment approaches.

14 Nov 2025

New approach revives DNA from historic medical tissues

Research institutions around the world house valuable genetic information that could help unlock countless medical mysteries. However, because DNA degrades over time, it is difficult for researchers to analyze DNA samples older than 20 years using conventional analytical approaches.

13 Nov 2025

Ultra-processed foods linked to precursors of early-onset colorectal cancer

Colorectal cancer used to be associated with old age, but diagnoses have become increasingly common in adults aged 50 or younger particularly in high-income countries like the United States.

13 Nov 2025

New drug combination gains Fast Track Designation for metastatic colorectal cancer

The U.S. Food and Drug Administration has granted Fast Track Designation to a new drug combination for metastatic colorectal cancer, following encouraging results from a clinical trial led in part by the University of Oklahoma Health Stephenson Cancer Center.

10 Nov 2025

Study reveals tumor defense mechanisms in colorectal cancer

Colorectal cancer is one of the leading causes of cancer death worldwide. In recent years, immunotherapies-treatments that reactivate the immune system to attack tumor cells-have transformed the treatment of many types of cancer.

7 Nov 2025