Colorectal Cancer

Colorectal Cancer is cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine before the anus). In the United States, it is the fourth most common cancer in men and women. Caught early, it is often curable.

Cured Meats, Nitrates, and Cancer Risk: Why Food Source and Processing Matter

From bacon and hot dogs to deli meats, cured meat products contain chemical compounds that increase the risk of cancer.

What is Colorectal Cancer?

Colorectal Cancer Symptoms

Microbial Dysbiosis and Colorectal Cancer

Colorectal Cancer and Organ Preservation

Colorectal Cancer Pathogenesis

Colorectal Cancer Prevention

What Causes Colorectal Cancer?

Colorectal Cancer Diagnosis

Colorectal Cancer Management

Colorectal Cancer Prognosis

Latest Colorectal Cancer News and Research

FDA approves atezolizumab combination for stage III colon cancer with deficient DNA mismatch repair

The Alliance for Clinical Trials in Oncology (Alliance) today announced that the U.S. Food and Drug Administration has approved the immunotherapy drug atezolizumab (Tecentriq) in combination with fluoropyrimidine and oxaliplatin chemotherapy, for the adjuvant treatment of patients with stage III colon cancer with deficient deoxyribonucleic acid (DNA) mismatch repair (dMMR).

9 Oct 2026

Lynch syndrome patients rarely use aspirin for cancer prevention

According to international studies, taking Acetylsalicylic acid daily can protect people with Lynch syndrome from developing colorectal cancer - even at low doses. Researchers from the University Hospital Bonn (UKB), the University of Bonn, and the Center for Integrated Oncology (CIO) Bonn, in collaboration with the self-help organization SemiColon, have now found that these scientific findings have so far been insufficiently incorporated into clinical practice.

9 Oct 2026

US counties with more medical debt see higher rates of several late-stage cancers

Higher medical debt is linked to more late-stage cancer diagnoses across U.S. counties.

9 Oct 2026

Disrupted circadian rhythms may influence tumor immunity and cancer spread

Epidemiological studies link light at night (LAN), shift work, chronic jet lag (CJL), and core clock gene mutations to higher cancer risk and aggressive spread, especially in breast and colorectal cancer.

8 Oct 2026

ASAC trial reveals aspirin fails to improve metastatic colorectal cancer survival

Colorectal cancer is one of the most common cancers worldwide, and up to half of patients develop liver metastases during the course of their disease.

5 Oct 2026

Blood tests can identify cancer neoantigens for personalized immunotherapy

Cancer neoantigens and neoantigen-specific T cells were identified from patient blood samples by analyzing circulating tumor DNA (ctDNA) and immune cells, respectively, and they largely matched those found through traditional tumor tissue biopsy in many patients.

29 Sep 2026

Late diagnosis and systemic gaps drive high cancer death rates in the Balkans

In the Balkans, cancer survival rates lag due to late diagnoses and weak screening programs, highlighting the need for improved early detection strategies.

From BGI Genomics 29 Sep 2026

Laser irradiation boosts antibody-antigen interactions to detect colorectal cancer

Researchers often use antibodies to detect specific molecules or biological markers, as they are remarkably precise at recognizing their targets.

25 Sep 2026

Why are more younger adults in the Eastern Mediterranean facing colorectal cancer?

A 22-country analysis of modeled GLOBOCAN 2022 data found 15,381 early-onset colorectal cancer cases and 6,965 related deaths across the WHO Eastern Mediterranean Region, with substantial differences between countries and comparatively high mortality. Projections suggest that annual case and death counts could rise markedly by 2050, largely due to demographic change, while the findings support screening and detection strategies tailored to local resources and disease burden.

24 Sep 2026

MIT biologists discover cellular pathway that triggers colon cancer spread

Most colon cancer deaths are caused by the spread of tumor cells beyond the colon, usually to the liver. In a new study, MIT biologists identified a cellular pathway necessary for colorectal cancer metastasis.

24 Sep 2026

Cancer incidence rises faster among people with type 2 diabetes

A nationwide study being presented at the Annual Meeting of The European Association for the Study of Diabetes (EASD) in Milan, Italy (Sept 28 – Oct 2) has found that people with type 2 diabetes (T2D) have a higher risk of developing cancer, with cancer incidence rising more among people with T2D than those without diabetes over the past 25 years, largely driven by obesity-related cancers.

22 Sep 2026

Garvan research reveals hidden inflammation behind high colon cancer risk

New research from the Garvan Institute of Medical Research has revealed for the first time that two closely related bowel diseases, currently treated in the same way, are fundamentally different.

22 Sep 2026

Sugary drinks stood out in this stomach cancer study, but diet drinks did not

In two large US prospective cohorts, consuming more than one sugar-sweetened beverage a day was associated with higher gastric cancer incidence compared with consuming less than one serving a month. Artificially sweetened beverages were not associated with gastric cancer incidence, and the authors called for further studies to confirm the findings and clarify possible biological mechanisms.

21 Sep 2026

Simple fecal test could help detect colorectal and pancreatic cancers

Gastrointestinal and pancreatobiliary cancers can be difficult to detect early, creating a need for practical, noninvasive approaches for early detection and risk assessment.

16 Sep 2026

New AACR report outlines future of cutting-edge cancer research

Today, the American Association for Cancer Research (AACR) released the 16th edition of its annual Cancer Progress Report.

16 Sep 2026

FDA clears trial of dual-targeted CAR T-cell therapy for cancer

The U.S. Food and Drug Administration this week granted permission for investigators at the University of Colorado Anschutz to conduct a clinical trial testing genetically engineered immune cells in adults with advanced colorectal cancer and pediatric patients with solid cancers who have exhausted standard treatment options.

11 Sep 2026

Coffee after colorectal cancer? Decaf and caffeine show different links with mortality

In a prospective analysis of 1,098 people with colorectal cancer, researchers found no significant association between total or caffeinated coffee intake and all-cause or colorectal cancer-specific mortality in the cohort overall. Decaffeinated coffee was associated with lower all-cause mortality, while the highest quartile of caffeine intake was associated with lower all-cause and colorectal cancer-specific mortality, although the observational study cannot establish causation.

10 Sep 2026

New AI tool automates colonoscopy quality assessment at scale

Colonoscopies are one of the most effective ways to prevent colorectal cancer, which is surging among young adults in the U.S. Yet, the quality of each procedure can vary substantially from one physician to another.

8 Sep 2026

Helicobacter pylori exposure linked to one in five cases of bowel cancer

Exposure to the stomach microbe Helicobacter pylori may be associated with more than 1 in 5 cases of bowel cancer worldwide, suggests an exploratory risk attribution study, published in the open access journal eGastroenterology.

8 Sep 2026

Microscopic peptide droplets reduce colorectal tumor growth in mice

Scientists from Nanyang Technological University, Singapore (NTU Singapore) have developed microscopic peptide droplets that deliver large amounts of gene-silencing molecules into cancer and immune cells, reducing the growth of hard-to-treat colorectal tumours by about 67 per cent in mice.

3 Sep 2026