Colorectal Cancer

Colorectal Cancer is cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine before the anus). In the United States, it is the fourth most common cancer in men and women. Caught early, it is often curable.

Cured Meats, Nitrates, and Cancer Risk: Why Food Source and Processing Matter

From bacon and hot dogs to deli meats, cured meat products contain chemical compounds that increase the risk of cancer.

What Causes Colorectal Cancer?

Colorectal Cancer and Organ Preservation

Colorectal Cancer Management

Colorectal Cancer Pathogenesis

Colorectal Cancer Prevention

Colorectal Cancer Symptoms

Microbial Dysbiosis and Colorectal Cancer

What is Colorectal Cancer?

Colorectal Cancer Diagnosis

Colorectal Cancer Prognosis

Latest Colorectal Cancer News and Research

Biosimilars reduce financial burden for cancer patients and insurers

Biologic drugs play an important role in treating cancers such as breast cancer and lymphoma, but their high costs can add to the financial burden of cancer care.

27 Aug 2026

New study tracks global colorectal cancer risk across 185 nations

Colorectal cancer has long been recognized as a major global health threat, but its burden is far from evenly distributed. Incidence and mortality rates vary dramatically across countries, and these differences are closely tied to socioeconomic development, dietary transitions, and the adoption of screening programs.

26 Aug 2026

Scientists found a distinct gut microbiome pattern in people with symptomatic diverticular disease

A multicenter Japanese study found that symptomatic uncomplicated diverticular disease (SUDD) was associated with reduced gut microbial diversity, increased abundance of the Ruminococcus gnavus group, and depletion of Coprococcus and other butyrate-producing bacteria. Predictive microbiome analysis also identified enrichment of pathways linked to exopolysaccharide biosynthesis and the cell cycle, although the observational design means these associations cannot establish causality.

25 Aug 2026

New discovery helps identify colorectal cancer patients at risk for metastasis

Researchers from the University of Turku in Finland and Gustave Roussy Institute in France have discovered a molecular mechanism that regulates whether the cells of an aggressive colorectal cancer are conventional or inverted when they spread in the body.

25 Aug 2026

Study maps rising lifetime risk of digestive cancers in China

The global landscape of oncology is shifting, and nowhere is this transition more complex or consequential than in China.

24 Aug 2026

A striking immune cell pattern emerges around a person’s 100th birthday

Single-cell immune profiling found that CD4 cytotoxic T lymphocytes become more abundant around age 100, showing stepwise differentiation and substantial clonal expansion. Ex vivo experiments also revealed cytokine plasticity within individual clones, supporting the hypothesis that these cells adapt to persistent antigens during healthy aging, although their direct role in longevity remains unproven.

23 Aug 2026

Active screening cuts colorectal cancer death risk drastically

People who take part in screening for colorectal cancer may have as much as 43 per cent lower risk of dying from the disease, according to new estimates published in JAMA Network Open by researchers at Karolinska Institutet and Umeå University in Sweden.

20 Aug 2026

Colorectal tumors may damage nerves before chemotherapy

Researchers at The University of Texas MD Anderson Cancer Center found that, in preclinical models of colorectal cancer, tumors can start damaging peripheral nerves before chemotherapy begins.

19 Aug 2026

A decades-long study raises questions about sugary drinks and stomach cancer

A large prospective U.S. study followed more than 111,000 adults to examine whether sugar-sweetened and artificially sweetened beverage intake was associated with gastric cancer incidence. Researchers identified 278 gastric cancer cases over 3.2 million person-years and found that associations differed according to beverage type and level of consumption.

19 Aug 2026

Special journal issue highlights precision prevention in cancer epidemiology

Cancer epidemiology is not merely about counting cases; it is a dynamic field that informs screening policies, resource allocation, and clinical trial design.

19 Aug 2026

High antioxidant diet linked to lower risk of cervical cancer in women

In research published in the International Journal of Gynecology & Obstetrics, a diet high in antioxidants was linked with a lower risk of cervical cancer in women.

19 Aug 2026

Study provides new insights into how IL-26 reshapes the tumor immune landscape

While cancer cells acquire malignant traits through epigenetic remodeling, it remains unclear how immune-derived inflammatory factors regulate the epigenetics of colorectal cancer cells.

18 Aug 2026

New drug delivers promising survival gains in pancreatic cancer

About 90% of people with pancreatic cancer have pancreatic ductal adenocarcinoma (PDAC), which is driven by an activating mutation in the KRAS gene.

9 Aug 2026

Piezo ion channels: Key regulators of digestive health and disease

Mechanosensitive Piezo ion channels, particularly Piezo1 and Piezo2, are gaining recognition as central regulators of digestive system physiology and disease.

7 Aug 2026

Tuft cell-like cancers exhibit unique biological characteristics across multiple organs

A growing body of evidence suggests that a rare epithelial cell type known as the tuft cell may play a far more significant role in cancer than previously recognized.

6 Aug 2026

Blocking ZFP36L2 protein may disrupt colorectal cancer metastatic growth

Digestion is hard on the cells that line the human gut, and they are constantly being shed and replaced. This renewal is driven by a population of tireless stem cells.

5 Aug 2026

Tumor-secreted protein makes lung blood vessels leaky to promote metastasis

A protein secreted by common cancer types makes blood vessels leakier to allow metastatic tumors to form in the lungs, according to a study led by investigators at Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center.

5 Aug 2026

Combination therapy improves progression-free survival in dMMR/MSI-H metastatic colorectal cancer

Patients with deficient DNA mismatch repair (dMMR) or microsatellite instability-high (MSI-H) metastatic colorectal cancer experienced a 58% reduction in the risk of disease progression or death when treated with atezolizumab plus modified FOLFOX6 and bevacizumab compared with atezolizumab alone, according to results from the NRG-GI004/SWOG S1610 COMMIT trial published recently in the Journal of Clinical Oncology.

29 Jul 2026

AI model predicts cancer diagnoses up to a year in advance using routine clinical data

Researchers developed Oncoformer, a multimodal transformer that analyzes longitudinal health records and chest X-rays to classify cancer, predict diagnoses up to one year in advance, infer tumor stage, and forecast treatment response and recurrence risk. Validation across large independent cohorts showed strong performance, although prospective trials in diverse, average-risk populations are needed before clinical use.

28 Jul 2026

New AI tool predicts bowel cancer relapse risk from routine slides

A new artificial intelligence (AI) tool developed by La Trobe University researchers could help predict which stage-two bowel cancer patients are at risk of relapse, in an advance that could ultimately lead to thousands getting life-saving treatment earlier.

28 Jul 2026