Colorectal Cancer News and Research

Latest Colorectal Cancer News and Research

Triplet therapy significantly improves survival in BRAF V600E-mutated metastatic colorectal cancer

First-line treatment with the triplet combination of encorafenib, cetuximab and mFOLFOX6 significantly improved survival compared to the standard of care in patients with BRAF V600E-mutated metastatic colorectal cancer, according to new data from the Phase III BREAKWATER trial led by researchers from The University of Texas MD Anderson Cancer Center.

30 May 2025

TRR 417 initiative aims to unlock new treatments for colorectal cancer

In the realm of colorectal cancer treatments beyond surgery and radiation, one key question gained prominence in recent years: Is the tumor's DNA repair system defective, making it "microsatellite unstable"? Around 15 to 20 percent of all tumors have this trait, making them likely candidates for successful immunotherapy.

30 May 2025

Study reveals rising toll of alcohol-linked cancer mortality across the United States

A new study led by experts at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, is the first to look at trends over time in alcohol-linked cancer mortality across the United States.

29 May 2025

New biomarkers could help improve detection and treatment of gastrointestinal diseases

Scientists have discovered a range of 'biomarkers' that could help to improve detection and treatment of gastrointestinal diseases (GIDs) such as gastric cancer (GC), colorectal cancer (CRC), and inflammatory bowel disease (IBD).

28 May 2025

New insights reveal EGFR as a target in KRAS-mutated colon cancer

KRAS mutations are among the most common genetic alterations in cancer and are considered particularly difficult to treat.

26 May 2025

Machine learning tool identifies metabolic clues in colorectal cancer

Scientists aiming to advance cancer diagnostics have developed a machine learning tool that is able to identify metabolism-related molecular profile differences between patients with colorectal cancer and healthy people.

22 May 2025

Meta analysis highlights prognostic role of circPVT1 in solid tumors

circPVT1 has emerged as a key regulator in disease progression and clinical outcomes. However, its prognostic relevance and association with clinicopathological parameters in solid malignancies remain to be fully elucidated.

22 May 2025

Gut bacteria help ease chemotherapy side effects and aid recovery

Intestinal microbes that survive chemo can rid the gut of excess chemo drugs and produce a vitamin that helps to stem nausea.

21 May 2025

Long noncoding RNA ESSENCE identified as key driver of colorectal cancer progression

Colorectal cancer (CRC) remains one of the most prevalent and deadly cancers worldwide, with rising incidence linked to dietary and lifestyle changes.

18 May 2025

RANBP2 identified as key regulator in the progression of multiple solid tumors

The nuclear pore complex protein RANBP2 has emerged as a critical factor in the development and progression of various solid malignancies.

12 May 2025

GLP-1RAs show added protection against cancer beyond weight reduction

New research being presented at this year's European Congress on Obesity (ECO) in Malaga, Spain (11-14 May) and published in the journal eClinicalMedicine finds that first generation weight-loss medications like liraglutide and exenatide appear to show anti-cancer benefits beyond weight loss.

11 May 2025

Cancer rates are climbing in younger adults and researchers want to know why

A new NIH-led study finds rising rates of 14 cancer types in Americans under 50, especially breast, colorectal, kidney, uterine, and pancreatic cancers. The research urges deeper investigation into shared risk factors and earlier screening strategies.

8 May 2025

Gastrointestinal cancer patterns vary across diverse Asian and Pacific Islander populations

The incidence of gastrointestinal cancers varies across Asian American, Native Hawaiian and other Pacific Islander communities, according to a study published March 15 in the journal Gastro Hep Advances.

7 May 2025

Gene-edited immune cells show promise against advanced GI cancers

Researchers at the University of Minnesota have completed a first-in-human clinical trial testing a CRISPR/Cas9 gene-editing technique to help the immune system fight advanced gastrointestinal (GI) cancers.

3 May 2025

Covered California pushes for better health care as federal spending cuts loom

Faced with potential federal spending cuts that threaten health coverage and falling childhood vaccination rates, Monica Soni, the chief medical officer of Covered California, has a lot on her plate — and on her mind.

2 May 2025

California’s primary care shortage persists despite ambitious moves to close gap

Sumana Reddy, a primary care physician, struggles on thin financial margins to run Acacia Family Medical Group, the small independent practice she founded 27 years ago in Salinas, a predominantly Latino city in an agricultural valley often called "the salad bowl of the world."

1 May 2025

Genetic variation found to influence tumor microbiota and colorectal cancer progression

Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. While scientists believe that gut microbiota play an important role in both the onset and progression of CRC, emerging evidence points to the significance of intratumoral microbiota-microbiota inside tumors-in CRC progression.

29 Apr 2025

‘Game-changer’ clinical trial launches for Australia’s second-deadliest cancer

A world-first clinical trial launched in Melbourne is being hailed a ‘game-changer’ for its potential to revolutionize the way people with bowel cancer are treated.

29 Apr 2025

New topical gel reduces painful rash from colorectal cancer treatment

Researchers from the UCLA Health Jonsson Comprehensive Cancer Center and The University of Texas MD Anderson Cancer Center have demonstrated that a novel topical BRAF inhibitor gel called LUT014 significantly reduces the severity of an acne-like rash, a common and painful side effect experienced by patients undergoing anti-EGFR therapies for colorectal cancer.

28 Apr 2025

MD Anderson researchers present promising clinical trial results at AACR 2025

Researchers from The University of Texas MD Anderson Cancer Center will present promising results from clinical trials in three minisymposia abstracts at the American Association for Cancer Research (AACR) Annual Meeting 2025.

26 Apr 2025