Coronary Artery Disease

Coronary artery disease is the most common type of heart disease and the leading cause of death worldwide. It occurs when the arteries that supply blood to the heart become narrowed or blocked by a buildup of "plaque" - cholesterol or other fatty deposits that build on the inner wall of the artery.

What is Coronary Artery Disease?

Coronary artery disease is another term used for atherosclerotic heart disease, a condition caused by a narrowing, hardening and furring of the walls of the coronary arteries.

Coronary Artery Disease Preventive Diets

Coronary Artery Disease Prevention

Coronary Artery Disease and Aspirin

Coronary Artery Disease Pathophysiology

Coronary Artery Disease Characteristics

Coronary Artery Disease Risk Factors

Coronary Artery Disease and Omega-3 Fatty Acids

Coronary Artery Disease Treatment

Coronary Artery Disease Angina

Latest Coronary Artery Disease News and Research

‘Natural bypass’ of the heart helps doctors avoid risky cardiac surgeries

Your heart already has its own built-in bypass system that predicts whether the heart muscle is alive or dead - according to new research from the University of East Anglia and Norfolk and Norwich University Hospital.

28 May 2026

One-time gene editing cuts LDL cholesterol in early hypercholesterolemia trial

A phase 1 NEJM interim analysis found that a single infusion of the investigational base-editing therapy VERVE-102 produced dose-dependent reductions in circulating PCSK9 protein and LDL cholesterol in adults with heterozygous familial hypercholesterolemia or premature coronary artery disease.

26 May 2026

Hydroxychloroquine lowers heart risks in skin lupus patients

A study led by investigators from Johns Hopkins Medicine found that some patients with discoid lupus erythematosus - a form of skin lupus commonly diagnosed in young to middle-aged Black women that causes disc-shaped plaques to form on the body - were less likely to experience complications, such as diabetes, hypertension and coronary artery disease if they were prescribed hydroxychloroquine.

26 May 2026

Indian adapted Mediterranean diet targets inflammation in heart disease trial

The paper describes a single-center randomized controlled trial testing whether an Indian Adapted Mediterranean Diet can reduce dietary inflammation in adults with stable coronary artery disease or moderate-to-high cardiovascular risk. The protocol will assess changes in the Dietary Inflammatory Index, inflammatory biomarkers, cardiometabolic risk factors, body measurements, and metabolic hormones over six months.

25 May 2026

Optimal revascularization strategies in patients with left main coronary artery disease

The EuroPCR Course Directors have selected 3 major late-breaking trials that will be presented for the first time during EuroPCR 2026 and are set to impact practice worldwide.

20 May 2026

Role of coronary revascularization in TAVI patients with severe aortic stenosis and CAD

The EuroPCR Course Directors have selected 3 major late-breaking trials that will be presented for the first time during EuroPCR 2026 and are set to impact practice worldwide.

20 May 2026

Patient intuition leads to urgent open-heart surgery at NYU Langone Hospital—Brooklyn

Shana Hale, a Brooklyn mother of two and a technology executive, noticed a mild burning sensation in her chest during her daily walks last summer.

20 May 2026

Pregnancy-related disorders may shape offspring heart health into adulthood

Hypertensive disorders in pregnancy may lead to lasting cardiovascular issues in offspring, highlighting the need for improved maternal health strategies.

19 May 2026

High-intensity interval exercise is most effective for heart patients

Endothelial dysfunction is a hallmark of cardiovascular disease (CVD) and plays a central role in vascular inflammation, thrombosis, and impaired vasodilation.

4 May 2026

New genetic risk report reveals hidden heart disease risk before symptoms appear

Researchers developed and externally validated integrated polygenic risk scores for eight cardiovascular conditions using large U.S.-based biobank data. The clinically orderable report may help identify inherited cardiovascular risk that traditional clinical markers can miss, although broader prospective validation is still needed.

30 Apr 2026

New genetic risk test estimates inherited risk for cardiovascular conditions

Researchers at Mass General Brigham Heart and Vascular Institute and collaborators have developed and validated a new genetic risk test that can estimate a person's inherited risk for eight common cardiovascular conditions, offering a more comprehensive approach to prevention.

29 Apr 2026

Study identifies key risk factors driving MASLD across populations

Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 32% of the US adult population.

23 Apr 2026

More steps cut chronic disease risk but cannot fully undo long sitting

Research shows higher daily step counts can mitigate risks of chronic diseases linked to prolonged sitting, emphasizing the need to reduce sedentary time.

10 Apr 2026

Early genetic signals connect diabetes subgroups to heart disease risk

A growing body of research shows that diabetes can be stratified into five different subgroups. Researchers at Lund University have now investigated whether a person's genetic predisposition to different diabetes subgroups can help assess the risk of developing coronary artery disease.

7 Apr 2026

Evolocumab trial could reshape how doctors treat high-risk cholesterol patients

A new ACC/AHA dyslipidemia guideline and editorial argue that guideline development is rigorous but can lag behind fast-moving science, using the VESALIUS-CV trial as a clear example. The trial showed that intensive LDL cholesterol lowering with evolocumab reduced cardiovascular events in high-risk patients without prior heart attack or stroke, with implications for future guideline updates.

6 Apr 2026

Study finds higher heart disease risk in long COVID patients

People with long COVID are at increased risk of developing cardiovascular disease, according to a new study from Karolinska Institutet published in eClinicalMedicine.

1 Apr 2026

Dual imaging reveals hidden causes of heart attacks without blockages

When Ashley Perlow felt a sharp pain shoot across her chest and into both wrists, she didn't think it could be a heart attack. She was 36, a new mom, and otherwise healthy.

30 Mar 2026

New clinical guideline adopts holistic approach to brain and heart health

A new brain–heart clinical practice guideline takes a holistic approach, integrating neurologic and mental health evidence with guidance for cardiovascular disease as many brain and heart conditions overlap and share similar risk factors.

30 Mar 2026

Deferring PCI before TAVR shows comparable outcomes in elderly patients

Older patients with coronary artery disease scheduled for transcatheter aortic valve replacement (TAVR) had comparable outcomes regardless of whether they underwent percutaneous coronary intervention (PCI) before TAVR, according to findings from the PRO-TAVI study presented at the American College of Cardiology's Annual Scientific Session (ACC.26).

29 Mar 2026

Left-ventricular unloading during angioplasty fails to improve patient outcomes

The first randomized trial to compare standard percutaneous coronary intervention (PCI), also known as coronary angioplasty, with PCI accompanied by the use of a temporary, miniaturized pump to support the heart in patients with both severe coronary heart disease and moderate to severe heart failure found no significant difference between the two approaches.

29 Mar 2026