Cystic Fibrosis News and Research

Latest Cystic Fibrosis News and Research

Normalizing p62 protein levels in immune system cells could reduce infection in CF patients

New research suggests that lowering excessive levels of a protein in immune system cells could be a strategy to clear an infection that is deadly to patients with cystic fibrosis (CF).

23 Jan 2013

Celtaxsys commences CTX-4430 Phase 1 study to treat pulmonary inflammation

Celtaxsys, Inc., a private biopharmaceutical company developing a new class of drugs to treat chronic inflammatory disorders, today announced the initiation of a first-in-human Phase 1 clinical study of CTX-4430, which blocks the pro-inflammatory enzyme Leukotriene A4 Hydrolase (LTA4H).

3 Jan 2013

Crofelemer receives FDA approval for treatment of HIV associated diarrhea

Glenmark Pharmaceuticals Limited announced today that the US Food and Drug Administration has provided Marketing approval to its partner in US, Salix Pharmaceuticals Limited, for Crofelemer 125 mg delayed-release tablets for the symptomatic relief of non-infectious diarrhea in patients with human immunodeficiency virus (HIV)/ acquired immune deficiency syndrome (AIDS) on anti-retroviral therapy (ART).

2 Jan 2013

AAV-based gene therapy cocktail may help extend lives of children with Canavan disease

Results of a clinical trial that began in 2001 show that a gene therapy cocktail conveyed into the brain by a molecular special delivery vehicle may help extend the lives of children with Canavan disease, a rare and fatal neurodegenerative disorder.

20 Dec 2012

Patients with sickle cell disease rely more on emergency room

Patients with sickle cell disease rely more on the emergency room as they move from pediatric to adult health care, according to researchers at Washington University School of Medicine in St. Louis.

10 Dec 2012

Viewpoints: GOP attack on Medicare, Medicaid could hurt critical programs; Will says Obama is repeating his overreach on health care

Congressional Republicans are insisting that big cuts to Medicare and Medicaid be on the table in the negotiations over the so-called fiscal cliff and deficit reduction. That stance is largely a political move against two programs, which have been critical to the public welfare for the past half-century.

30 Nov 2012

CLCA1 molecule plays a special role in the mucus pathway

Respiratory conditions that restrict breathing such as asthma and chronic obstructive pulmonary disease (COPD) are common killers worldwide. But no effective treatments exist to address the major cause of death in these conditions - excess mucus production.

26 Nov 2012

Chronic suppurative lung disease: an interview with Dr Robyn Marsh

Chronic suppurative lung disease, or CSLD, is used to describe a range of lung diseases characterised by a chronic wet cough and progressive lung damage. We are interested in the non-cystic fibrosis forms of the disease with a focus on bronchiectasis – the severe form of CSLD.

26 Nov 2012

First evidence of blood vessel dysfunction found in healthy young people with cystic fibrosis

The first evidence of blood vessel dysfunction has been found in a small cohort of generally healthy young people with cystic fibrosis, researchers report.

26 Nov 2012

Aradigm’s Lipoquin provides full protection in murine models of pneumonic plague

Scientists from the UK Defence Science and Technology Laboratory (Dstl) report, in a preliminary study, that they have demonstrated that a single dose of Aradigm Corporation's liposomal ciprofloxacin formulation Lipoquin administered 24 hours after exposure to a lethal dose of the bacterium Yersinia pestis provided full protection in a murine model of pneumonic plague.

20 Nov 2012

CFFT announces major expansion of research collaboration with Pfizer

Cystic Fibrosis Foundation Therapeutics Inc. (CFFT), the nonprofit drug discovery and development affiliate of the Cystic Fibrosis Foundation, today announced a major expansion of its research collaboration with Pfizer Inc. designed to discover new drugs to treat people with the most common mutation of CF, Delta F508.

20 Nov 2012

Researchers discover cellular pathway that causes lung-damaging inflammation in CF

Vancouver researchers have discovered the cellular pathway that causes lung-damaging inflammation in cystic fibrosis (CF), and that reducing the pathway's activity also decreases inflammation.

8 Nov 2012

Researchers sequence the DNA of 6,700 exomes of cystic fibrosis patients

A multi-institutional team of researchers has sequenced the DNA of 6,700 exomes, the portion of the genome that contains protein-coding genes, as part of the National Heart, Lung and Blood Institute (NHLBI)-funded Exome Sequencing Project, one of the largest medical sequencing studies ever undertaken.

7 Nov 2012

Ion AmpliSeq Community Panels from Life Technologies

Life Technologies Corporation today announced Ion AmpliSeq Community Panels, a community-driven solution to gene panel sequencing that leverages the expertise of scientific thought leaders and the Ion Community to create gene panels for conditions ranging from cancer to inherited diseases.

7 Nov 2012

Researchers show how bacteria control processes in human cells

Bacteria can talk to each other via molecules they themselves produce. The phenomenon is called quorum sensing, and is important when an infection propagates. Now, researchers at Link-ping University in Sweden are showing how bacteria control processes in human cells the same way.

6 Nov 2012

Gene silencing technology used to fight RSV and influenza

New hope has arrived for the fight against two deadly viral infections, RSV and influenza, as Griffith researchers prepare to develop a cutting-edge approach to treatment delivery.

6 Nov 2012

Study shows anxiety-promoting parental behaviors affect children

Parents with social anxiety disorder are more likely than parents with other forms of anxiety to engage in behaviors that put their children at high risk for developing angst of their own, according to a small study of parent-child pairs conducted at Johns Hopkins Children's Center.

3 Nov 2012

Obstructive sleep apnea common in young cystic fibrosis children

Children with stable cystic fibrosis have an increased risk for obstructive sleep apnea, which could cause sleep disruption, researchers report.

2 Nov 2012

Imatinib mesylate effectively treats children with neurofibromatosis type 1 tumors

Physician-researchers at Indiana University School of Medicine have reported the first effective therapy for a class of previously untreatable and potentially life-threatening tumors often found in children.

2 Nov 2012

Researchers zero in on process by which stem cells maintain proper undifferentiated state

The ability of embryonic stem cells to differentiate into different types of cells with different functions is regulated and maintained by a complex series of chemical interactions, which are not well understood. Learning more about this process could prove useful for stem cell-based therapies down the road. New research from a team led by Carnegie's Yixian Zheng zeroes in on the process by which stem cells maintain their proper undifferentiated state.

29 Oct 2012

Cystic Fibrosis News and Research

Latest Cystic Fibrosis News and Research

Normalizing p62 protein levels in immune system cells could reduce infection in CF patients

Celtaxsys commences CTX-4430 Phase 1 study to treat pulmonary inflammation

Crofelemer receives FDA approval for treatment of HIV associated diarrhea

AAV-based gene therapy cocktail may help extend lives of children with Canavan disease

Patients with sickle cell disease rely more on emergency room

Viewpoints: GOP attack on Medicare, Medicaid could hurt critical programs; Will says Obama is repeating his overreach on health care

CLCA1 molecule plays a special role in the mucus pathway

Chronic suppurative lung disease: an interview with Dr Robyn Marsh

First evidence of blood vessel dysfunction found in healthy young people with cystic fibrosis

Aradigm’s Lipoquin provides full protection in murine models of pneumonic plague

CFFT announces major expansion of research collaboration with Pfizer

Researchers discover cellular pathway that causes lung-damaging inflammation in CF

Researchers sequence the DNA of 6,700 exomes of cystic fibrosis patients

Ion AmpliSeq Community Panels from Life Technologies

Researchers show how bacteria control processes in human cells

Gene silencing technology used to fight RSV and influenza

Study shows anxiety-promoting parental behaviors affect children

Obstructive sleep apnea common in young cystic fibrosis children

Imatinib mesylate effectively treats children with neurofibromatosis type 1 tumors

Researchers zero in on process by which stem cells maintain proper undifferentiated state

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering

Cystic Fibrosis News and Research

Latest Cystic Fibrosis News and Research

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering

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