Dopamine News and Research

Latest Dopamine News and Research

UCL scientists explain Parkinson's disease patients' ICBs

Scientists at UCL have explained Parkinson's patients' risky behaviour, a rare side effect of standard treatments for the disease. The finding has implications for future medication of patients.

23 Jun 2010

MJFF supports Ceregene's CERE-120 Phase 2 study for PD with $2.5M award

The Michael J. Fox Foundation for Parkinson's Research (MJFF) will provide $2.5 million to support Ceregene Inc.'s new Phase 2 study of CERE-120. This novel gene therapy product delivers the gene for neurturin, a potent neurotrophic (growth) factor that has shown potential to improve the status of degenerating neurons in both preclinical and clinical studies. CERE-120 has the potential to improve motor function as well as slow Parkinson's disease (PD) progression.

23 Jun 2010

Neurologix announces positive results from Phase 2 trial of NLX-P101 for advanced PD

Neurologix, Inc., today announced positive results in a Phase 2 trial of its investigational gene therapy for advanced Parkinson's disease, NLX-P101. Study participants who received NLX-P101 experienced statistically significant and clinically meaningful improvements in off-medication motor scores compared to control subjects who received sham surgery.

22 Jun 2010

Neupro improves wellbeing impaired by pain related to Restless Legs Syndrome

The first data to show that Neupro® (rotigotine transdermal system) significantly improved wellbeing and daily activities that are often impaired by pain related to Restless Legs Syndrome (RLS) were presented this week at the 14th International Congress of Parkinson's Disease and Movement Disorders in Buenos Aires, Argentina.

18 Jun 2010

Study reveals increase of enzyme MAO-A in female brain during immediate postpartum period

Within the first week after giving birth, up to 70 percent of all women experience symptoms of the baby blues. While most women recover quickly, up to 13 percent of all new mothers suffer from symptoms of a clinical-level postpartum depression. Postpartum depression is defined as a major depressive episode starting within 4 weeks after delivery and is a significant public health problem. Postpartum blues represents a major risk factor for developing postpartum depression and severe postpartum blues symptoms can be viewed as a prodromal stage for postpartum depression.

17 Jun 2010

Prevalence of GID in PD patients has impact on clinical and societal outcomes: Study

New data from a retrospective cohort study showed that up to three quarters of patients with Parkinson's disease developed gastrointestinal disorders that can have a substantial adverse effect on major PD-related clinical and health economic outcomes. These data were presented at the 14th International Congress of Parkinson's Disease and Movement Disorders in Buenos Aires, Argentina (June 13-17, 2010).

16 Jun 2010

New research may help unravel cellular brain activity involved in human decisions

Crayfish make surprisingly complex, cost-benefit calculations, finds a University of Maryland study, opening the door to a new line of research that may help unravel the cellular brain activity involved in human decisions.

16 Jun 2010

Olfactory function tests could help in treating patient in early stages of PD

A fast, simple and non invasive test of the ability to smell may be an important tool to screen people who are likely to develop Parkinson's disease, in which motor symptoms only become evident at a later stage of the disease, a German scientist will tell the annual conference of the European Society of Human Genetics today (Saturday).

14 Jun 2010

Tel Aviv University researchers invent new tool to control risk of runaway stem cells

Stem cell research holds promise for improving the quality of human life ― especially embryonic stem cells, which can potentially develop into any tissue in the human body. However, basic scientific problems still remain unresolved -- but Tel Aviv University researchers are leading the way to inventive solutions.

9 Jun 2010

Antiemetic-regimen with fosaprepitant injection provides similar protection against CINV as oral EMEND

Merck announced today results from a new non-inferiority trial of an antiemetic regimen containing fosaprepitant dimeglumine administered as a single intravenous (IV) 150-mg dose in combination with a 5-HT3 antagonist and dexamethasone compared with a three-day regimen of aprepitant with a 5-HT3 antagonist and dexamethasone for the prevention of chemotherapy-induced nausea and vomiting (CINV) in patients receiving a first cycle of cisplatin-based chemotherapy.

4 Jun 2010

Study: Rash adolescent behaviors tied to biological motivations

There are biological motivations behind the stereotypically poor decisions and risky behavior associated with adolescence, new research from a University of Texas at Austin psychologist reveals.

4 Jun 2010

Study of methylphenidate for cancer-related fatigue benefits patients with stage III/IV disease

Cancer-related fatigue is often a major problem for cancer patients, beginning at diagnosis, during treatment and after completing therapy. Researchers at Mayo Clinic and the North Central Cancer Treatment Group (NCCTG) recently completed a study testing methylphenidate in the treatment of cancer-related fatigue and found that, while it did not improve fatigue for a broad group of patients, the data did not rule out a benefit for those with stage III/IV cancer.

4 Jun 2010

Medtronic DBS Therapy improves motor function in patients with advanced Parkinson's disease: Study

In the largest, randomized, controlled study of deep brain stimulation for Parkinson's disease, Medtronic DBS Therapy was shown to improve motor function for up to two years in patients with advanced Parkinson's disease, showing equally strong efficacy for the two most common surgical targets used for the therapy.

3 Jun 2010

Biovail: BLS, Kyowa Hakko Kirin sign license agreement

Biovail Corporation today announced that its subsidiary, Biovail Laboratories International SRL, has entered into a license agreement with Kyowa Hakko Kirin Co., Ltd. BLS has acquired the U.S. and Canadian rights to commercialize products containing istradefylline - a new chemical entity targeted for the treatment of Parkinson's disease.

3 Jun 2010

NCCTG study testing methylphenidate in treatment of cancer-related fatigue completed

Cancer-related fatigue is often a major problem for cancer patients, beginning at diagnosis, during treatment and after completing therapy. Researchers at Mayo Clinic and the North Central Cancer Treatment Group recently completed a study testing methylphenidate in the treatment of cancer-related fatigue and found that, while it did not improve fatigue for a broad group of patients, the data did not rule out a benefit for those with stage III/IV cancer.

3 Jun 2010

BioTime offers 5 new human stem cell lines developed using ACTCellerate technology for research use

BioTime, Inc. announced today that on June 1, 2010 the Company will be offering for sale five new human stem cell lines for research use only. These cell lines were developed using BioTime's ACTCellerate™ technology. These highly purified, novel, and scalable cell lines are embryonic progenitors, meaning that they are intermediate between human embryonic stem cells and fully developed cells.

31 May 2010

Combination therapy improves patients with depression symptoms: Study

New data presented today at the American Psychiatric Association's annual meeting suggests a benefit to combining L-methylfolate, a prescription medical food called Deplin, with an antidepressant at the start of treatment. This retrospective analysis showed a significantly greater improvement in depression symptoms in a shorter period of time, when patients with Major Depressive Disorder were started on combination therapy.

25 May 2010

Researchers test NicVAX vaccine to help people quit smoking, avoid relapses

In a unique twist to a decades-old health crisis, Michigan State University researchers are testing a new vaccine to help people quit smoking and avoid relapses.

21 May 2010

Role of neurotransmitter acetylcholine may suggest new treatment for Parkinson's disease: Researchers

Chicago and Montreal researchers studying the lowly lamprey eel have identified an overlooked nervous system pathway running parallel to known brainstem locomotor command circuitry in vertebrates such as birds, fishes and mammals.

20 May 2010

Research findings help explain diverse genetic susceptibility for alcohol use disorders

A genetic variant of a receptor in the brain's reward circuitry plays an important role in determining whether the neurotransmitter dopamine is released in the brain following alcohol intake, according to a study led by researchers at the National Institute on Alcohol Abuse and Alcoholism, part of the National Institutes of Health. Dopamine is involved in transmitting the euphoria and other positive subjective effects produced by alcohol.

19 May 2010

Dopamine News and Research

Latest Dopamine News and Research

UCL scientists explain Parkinson's disease patients' ICBs

MJFF supports Ceregene's CERE-120 Phase 2 study for PD with $2.5M award

Neurologix announces positive results from Phase 2 trial of NLX-P101 for advanced PD

Neupro improves wellbeing impaired by pain related to Restless Legs Syndrome

Study reveals increase of enzyme MAO-A in female brain during immediate postpartum period

Prevalence of GID in PD patients has impact on clinical and societal outcomes: Study

New research may help unravel cellular brain activity involved in human decisions

Olfactory function tests could help in treating patient in early stages of PD

Tel Aviv University researchers invent new tool to control risk of runaway stem cells

Antiemetic-regimen with fosaprepitant injection provides similar protection against CINV as oral EMEND

Study: Rash adolescent behaviors tied to biological motivations

Study of methylphenidate for cancer-related fatigue benefits patients with stage III/IV disease

Medtronic DBS Therapy improves motor function in patients with advanced Parkinson's disease: Study

Biovail: BLS, Kyowa Hakko Kirin sign license agreement

NCCTG study testing methylphenidate in treatment of cancer-related fatigue completed

BioTime offers 5 new human stem cell lines developed using ACTCellerate technology for research use

Combination therapy improves patients with depression symptoms: Study

Researchers test NicVAX vaccine to help people quit smoking, avoid relapses

Role of neurotransmitter acetylcholine may suggest new treatment for Parkinson's disease: Researchers

Research findings help explain diverse genetic susceptibility for alcohol use disorders

Todd Bauman and Chris Povich

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Dopamine News and Research

Latest Dopamine News and Research

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Scaling organ‑chip technology for human‑relevant drug discovery

Unlocking drug amorphization: Continuous, solvent-free twin screw granulation

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