Dopamine News and Research

Latest Dopamine News and Research

Breakthrough produces Parkinson's patient-specific stem cells free of harmful reprogramming genes

Deploying a method that removes potentially cancer-causing genes, Whitehead Institute researchers have "reprogrammed" human skin cells from Parkinson's disease patients into an embryonic-stem-cell-like state.

5 Mar 2009

Faulty signalling in the brain may cause schizophrenia

In the biggest study of its kind, scientists looking in detail at brain samples donated by people with the condition have identified 49 genes that work differently in the brains of schizophrenia patients compared to controls.

3 Mar 2009

Researchers discover gene variation linked to cocaine addiction and cocaine-induced paranoia

Researchers from Boston University School of Medicine (BUSM) and Yale University School of Medicine and the University of Connecticut School of Medicine, have discovered that variants in the á-endomannosidase (MANEA) gene are associated with cocaine addiction and cocaine-induced paranoia in European American and African American populations.

2 Mar 2009

New insights into addiction

A new comprehensive review by researchers at the Montreal Neurological Institute (MNI), McGill University and the University of Cambridge, England provides vital insights into the neurological basis of addiction by investigating Parkinson's disease patients, who in some instances develop various addictions when undergoing medical treatment.

25 Feb 2009

Mental fatigue impairs physical performance in humans

When participants performed a mentally fatiguing task prior to a difficult exercise test, they reached exhaustion more quickly than when they did the same exercise when mentally rested, a new study finds.

24 Feb 2009

More evidence showing exercise helps people give up smoking

Research from the University of Exeter reveals for the first time, that changes in brain activity, triggered by physical exercise, may help reduce cigarette cravings.

10 Feb 2009

Cognitive training can alter the biochemistry of the brain

Researchers at the Swedish medical university Karolinska Institutet have shown for the first time that the active training of the working memory brings about visible changes in the number of dopamine receptors in the human brain.

8 Feb 2009

Safinamide significantly improved motor function in patients with advanced Parkinson's disease

Merck Serono, a division of Merck KGaA, Darmstadt, Germany, and its partner Newron Pharmaceuticals SpA has announced that the first Phase III trial of investigational agent safinamide as adjunctive therapy to levodopa (study 016) met its primary endpoint by increasing daily "ON" time in mid- to late-stage Parkinson's disease patients with motor fluctuations by 1.3 hours.

5 Feb 2009

Novel gene may cause restless legs syndrome in a large family

In 2005, a woman who had trouble sleeping asked Siong-Chi Lin, M.D., for help. Dr. Lin, a sleep disorders specialist at the Mayo Clinic campus in Florida, diagnosed restless legs syndrome.

3 Feb 2009

Genetics may predict risk for relapse among alcohol-dependent patients

In Poland, alcohol dependence (AD) affects about four percent of the population, causing about 10,000 deaths per year.

3 Feb 2009

Genetic change prevents cell death in mouse model of Parkinson's disease

By shifting a normal protective mechanism into overdrive, a University of Wisconsin-Madison scientist has completely shielded mice from a toxic chemical that would otherwise cause Parkinson's disease.

2 Feb 2009

Researchers discover link between brain iron levels and serotonin

Vanderbilt University Medical Center investigators have found a surprising link between brain iron levels and serotonin, a neurotransmitter involved in neuropsychiatric conditions ranging from autism to major depression.

29 Jan 2009

Discovery of brain's memory 'buffer' in single cells

Individual nerve cells in the front part of the brain can hold traces of memories on their own for as long as a minute and possibly longer, researchers at UT Southwestern Medical Center have found.

27 Jan 2009

Researchers learn some of nicotine's secrets

Duke University Medical System researchers have discovered there are differing taste pathways for nicotine, which could provide a new approach for future smoking-cessation products.

23 Jan 2009

Risk takers do so because their brains are less able to process dopamine

According to scientists risk takers and drug abusers behave the way they do because their brains are less able to process dopamine.

30 Dec 2008

Researchers find brain's reward and stress signaling circuits are intertwined in complex ways

Vanderbilt University Medical Center investigators have now discovered a functional link between reward and stress. They found that dopamine - the brain's chief reward signal - works through corticotrophin-releasing factor (CRF) - the brain's main stress signal - to increase the activity of a brain region involved in addiction relapse.

16 Dec 2008

Losing sense of smell may indicate Parkinson's

Many individuals with Parkinson's disease are able to recall losing their sense of smell well before the onset of more commonly recognized symptoms such as tremors, impaired dexterity, speech problems, memory loss and decreased cognitive ability.

12 Dec 2008

Sugar is addictive

A Princeton University scientist will present new evidence today demonstrating that sugar can be an addictive substance, wielding its power over the brains of lab animals in a manner similar to many drugs of abuse.

10 Dec 2008

Researchers find inherited genetic variation in nicotine addiction

A new study from the Abramson Cancer Center and Department of Psychiatry in the University of Pennsylvania School of Medicine shows that smokers who carry a particular version of a gene for an enzyme that regulates dopamine in the brain may suffer from concentration problems and other cognitive deficits when abstaining from nicotine - a problem that puts them at risk for relapse during attempts to quit smoking.

10 Dec 2008

New experimental treatment for Tourette's syndrome

The University of Rochester Medical Center (URMC) is leading a multi-center clinical research study of a new experimental treatment for Tourette's syndrome.The study will examine whether or not a drug that alters the chemical activity in the brain can alleviate the symptoms of the disease.

2 Dec 2008