Dopamine News and Research

Latest Dopamine News and Research

Study supports hypothesis that disulfiram reduces drug consumption by blocking DβH

Disulfiram was the first medication approved for the treatment of alcoholism over 50 years ago. It works, at least in part, by preventing the metabolism of an alcohol by-product, acetaldehyde. High levels of acetaldehyde in the body quickly cause unpleasant symptoms, including nausea, vomiting, headache, and accelerated heart rate. Thus, disulfiram provides a very strong incentive to avoid drinking.

1 Feb 2013

Study illuminates the response of dopaminergic neurons to changes in temperature

While the wooly musk ox may like it cold, fruit flies definitely do not. They like it hot, or at least warm. In fact, their preferred optimum temperature is very similar to that of humans-76 degrees F.

31 Jan 2013

Social isolation increases risk of addiction to amphetamine and alcohol

Rats that are socially isolated during a critical period of adolescence are more vulnerable to addiction to amphetamine and alcohol, found researchers at The University of Texas at Austin. Amphetamine addiction is also harder to extinguish in the socially isolated rats.

24 Jan 2013

UB scientists propose first genomic explanation for schizophrenia

New University at Buffalo research demonstrates how defects in an important neurological pathway in early development may be responsible for the onset of schizophrenia later in life.

23 Jan 2013

Neurophysiologic mechanisms of deep-brain stimulation unveiled

The beneficial effects of subthalamic nucleus stimulation in patients with Parkinson’s disease are partly down to compensatory activation of nonmotor dopamine pathways during exercise, research suggests.

22 Jan 2013

Possible connection between mitochondrial CYP2D6 and Parkinson's

With a new insight into a model of Parkinson's disease, researchers from the University of Pennsylvania School of Veterinary Medicine have identified a novel target for mitigating some of the disease's toll on the brain.

19 Jan 2013

Stress in adolescence can cause severe mental illness in young adulthood

Working with mice, Johns Hopkins researchers have established a link between elevated levels of a stress hormone in adolescence — a critical time for brain development — and genetic changes that, in young adulthood, cause severe mental illness in those predisposed to it.

18 Jan 2013

Dopamine synthesis increased in patients at high risk for psychosis

UK study results show that patients at ultra-high risk for psychosis have elevated dopamine synthesis capacity in the dorsal striatum.

17 Jan 2013

Reviva Pharmaceuticals completes enrollment in RP5063 phase 2 trial for schizophrenia

Reviva Pharmaceuticals, Inc., a privately held drug discovery and development company, today announces completion of patient enrollment in the phase 2 clinical trial of RP5063 for the treatment of schizophrenia and schizoaffective disorder.

16 Jan 2013

Vanderbilt University, AstraZeneca partner to identify candidate drugs for major brain diseases

Today, AstraZeneca and Vanderbilt University announced they have signed a research collaboration agreement to identify candidate drugs aimed at treating psychosis and other neuropsychiatric symptoms associated with major brain diseases such as Alzheimer's disease and schizophrenia.

16 Jan 2013

Patients with Parkinson's develop artistic talents after dopamine-inducing therapy

Parkinson's experts across the world have been reporting a remarkable phenomenon - many patients treated with drugs to increase the activity of dopamine in the brain as a therapy for motor symptoms such as tremors and muscle rigidity are developing new creative talents, including painting, sculpting, writing, and more.

16 Jan 2013

Dopamine-related drug exposure, Parkinson's increase risk of impulse control problems

Parkinson's disease itself does not increase the risk of impulse control problems such as compulsive gambling and shopping that have been seen in people taking certain drugs for Parkinson's disease, according to new research published in the January 8, 2013, print issue of Neurology, the medical journal of the American Academy of Neurology.

9 Jan 2013

Penn study suggests dopamine treatments may play role in increasing impulsivity

While approximately one in five Parkinson's disease patients experience impulse control disorder symptoms, the disease itself does not increase the risk of gambling, shopping, or other impulsivity symptoms, according to research from the Perelman School of Medicine at the University of Pennsylvania.

8 Jan 2013

Link between Parkinson's and benomyl

For several years, neurologists at UCLA have been building a case that a link exists between pesticides and Parkinson's disease. To date, paraquat, maneb and ziram - common chemicals sprayed in California's Central Valley and elsewhere - have been tied to increases in the disease, not only among farmworkers but in individuals who simply lived or worked near fields and likely inhaled drifting particles.

6 Jan 2013

DRD4 7R allele can contribute to longevity

A variant of a gene associated with active personality traits in humans seems to also be involved with living a longer life, UC Irvine and other researchers have found.

4 Jan 2013

Females students drink more intensively in shorter periods of time

Researchers from the HealthyFit group at the University of Vigo have studied university students' lifestyles; their analysis, which includes alcohol and illegal drug consumption habits, sport and food, concludes that most students indulge in unhealthy behaviour. One of the main results of the study is the high consumption of alcohol.

29 Dec 2012

Parkinson’s: an interview with Steve Ford, CEO of Parkinson’s UK

Parkinson’s disease is a neurological condition that is caused when brain cells, that produce the chemical messenger dopamine, start to die.

24 Dec 2012

GI bacteria exert some control over their hosts' appetites: Review

Over the last half decade, it has become increasingly clear that the normal gastrointestinal (GI) bacteria play a variety of very important roles in the biology of human and animals. Now Vic Norris of the University of Rouen, France, and coauthors propose yet another role for GI bacteria: that they exert some control over their hosts' appetites.

20 Dec 2012

Smoking ‘worsens hangovers’

People who smoke more than usual on the same day as drinking heavily are at increased risk for a hangover the following morning, with heavier smoking leading to a worse hangover, researchers say.

14 Dec 2012

LED light instantly triggers or reverses depression-like behavior in rodents

A specific pattern of neuronal firing in a brain reward circuit instantly rendered mice vulnerable to depression-like behavior induced by acute severe stress, a study supported by the National Institutes of Health has found. When researchers used a high-tech method to mimic the pattern, previously resilient mice instantly succumbed to a depression-like syndrome of social withdrawal and reduced pleasure-seeking - they avoided other animals and lost their sweet tooth.

13 Dec 2012

Dopamine News and Research

Latest Dopamine News and Research

Study supports hypothesis that disulfiram reduces drug consumption by blocking DβH

Study illuminates the response of dopaminergic neurons to changes in temperature

Social isolation increases risk of addiction to amphetamine and alcohol

UB scientists propose first genomic explanation for schizophrenia

Neurophysiologic mechanisms of deep-brain stimulation unveiled

Possible connection between mitochondrial CYP2D6 and Parkinson's

Stress in adolescence can cause severe mental illness in young adulthood

Dopamine synthesis increased in patients at high risk for psychosis

Reviva Pharmaceuticals completes enrollment in RP5063 phase 2 trial for schizophrenia

Vanderbilt University, AstraZeneca partner to identify candidate drugs for major brain diseases

Patients with Parkinson's develop artistic talents after dopamine-inducing therapy

Dopamine-related drug exposure, Parkinson's increase risk of impulse control problems

Penn study suggests dopamine treatments may play role in increasing impulsivity

Link between Parkinson's and benomyl

DRD4 7R allele can contribute to longevity

Females students drink more intensively in shorter periods of time

Parkinson’s: an interview with Steve Ford, CEO of Parkinson’s UK

GI bacteria exert some control over their hosts' appetites: Review

Smoking ‘worsens hangovers’

LED light instantly triggers or reverses depression-like behavior in rodents

Quality, Patient Safety and Innovation Manager at Elsevier

How Bruker worked with the University of Manchester on mapping the dynamics of complex protein

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Dopamine News and Research

Latest Dopamine News and Research

Quality, Patient Safety and Innovation Manager at Elsevier

How Bruker worked with the University of Manchester on mapping the dynamics of complex protein

Real-time Raman monitoring for pharmaceutical hot melt extrusion

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