Embryogenesis News and Research

Latest Embryogenesis News and Research

NIH awards more than $8 million to support seven high-risk, high-reward projects at Penn Medicine

The National Institutes of Health has awarded grants to researchers in the Perelman School of Medicine at the University of Pennsylvania to support "highly innovative and broadly impactful" biomedical science through the NIH Common Fund's High-Risk, High-Reward Research program. The seven awards total approximately $8.2 million over five years,

8 Oct 2021

Scientists create a novel cell model for understanding human development

The earliest moments of human development—between the time of fertilization and when the embryo implants in the womb—have remained opaque to scientists.

9 Sep 2021

HMGA1 plays role in gastric cancer cell proliferation and metastasis

Aging-US published "HMGA1 promotes gastric cancer growth and metastasis by transactivating SUZ12 and CCDC43 expression" which reported that HMGA1 is overexpressed in GC cells and the high expression of HMGA1 was correlated with worse survival in GC patients using a bioinformatics assay.

19 Aug 2021

Hedgehog-signaling inhibitor may shift tumor-associated macrophages back to cancer fighters

A form of cell communication called hedgehog signaling is vital for embryonic development in mammals.

16 Aug 2021

Eggs and embryos go through a more dynamic and complex journey than previously thought

The journey of the egg and the embryo through the fallopian tube or oviduct toward the uterus is not well understood, mainly because it is inaccessible for direct imaging.

14 Jul 2021

Scientists unravel mechanisms involved in epithelial integrity

To enable tissue renewal, human tissues constantly eliminate millions of cells, without jeopardizing tissue integrity, form and connectivity.

9 Jul 2021

Deletion of an embryonic gene in liver cells completely wipes out bile ducts of newborn mice

Scientists from the University of Pittsburgh School of Medicine described a new phenomenon in which the deletion of a single gene involved in liver embryogenesis completely wipes out bile ducts of newborn mice.

6 Jul 2021

Researchers determine patterns of nuclear alignment responsible for LR-asymmetrical changes in invertebrates

On the outside, animals often appear bilaterally symmetrical with mirror-image left and right features. However, this balance is not always reflected internally, as several organs such as the lungs and intestines are left-right (LR) asymmetrical.

15 Jun 2021

Researchers discover possible origin of neuroblastoma in the adrenal glands

Neuroblastoma is a childhood cancer, most commonly affecting children aged between 2 -3 and can be fatal. Since the tumor cells resemble certain cells in the adrenal glands, a joint research group from MedUni Vienna's Center for Brain Research and the Swedish Karolinska Institute investigated the cellular origin of these cells and sympathetic neurons during the embryonic development of human adrenal glands.

7 May 2021

Study shows how signaling pathways operate on molecular and cellular levels

Scientists have made a pivotal breakthrough in understanding the way in which cells communicate with each other.

9 Apr 2021

RPS-12 protein overproduction appears to trigger breast cancer and other malignancies

Using the developing eye of the fruit fly as a test platform, researchers found that RPS-12 protein overproduction appears to trigger triple-negative breast cancer and possibly some other malignancies.

29 Jan 2021

Study shows neuropeptide corazonin regulates the release of diapause hormone in silkworms

Diapause is a seasonal adaptation strategy of insects and animals where biological functions are put on hold, such as insect eggs that remain dormant until conditions are more favorable to hatch.

21 Dec 2020

Researchers explain the role of enzyme that facilitates appropriate development of mouse embryo

The body plan of an organism, crafted over millennia of evolutionary trial and error, is so exquisitely fine-tuned that even a subtle deviation can be detrimental to individual survival and reproductive success.

17 Dec 2020

Researchers identify specific target sites for DNA methylases

DNA methylation performs an essential function in mammalian ontogeny. It is also known that abnormalities in this process cause the development of cancers such as leukemia.

22 Jul 2020

Exploring the molecular landscape of the aortic niche and beyond

Researchers from the group of Catherine Robin at the Hubrecht Institute characterized the molecular landscape of the aorta that supports the generation of the first Hematopoietic Stem Cells (HSCs) in the embryo.

4 Jun 2020

ISSCR 2020 Virtual Meeting to deliver comprehensive scientific education program

The International Society for Stem Cell Research has transformed its annual scientific meeting into a virtual experience, bringing the global stem cell community together to share knowledge, collaborate, and network.

2 Jun 2020

Research demonstrates control mechanism of force-induced cell-to-cell attachment

Using the amphibian Xenopus laevis as a model, Drs. Noriyuki Kinoshita and Naoto Ueno from the National Institute for Basic Biology, Japan and Dr. Ileana Cristea from Princeton University, USA have demonstrated that physical forces, such as centrifugal force, enhance cell-to-cell attachment and increase the stiffness of embryonic tissues as a result of force-induced cell shape change.

18 Mar 2020

SPRK1 enzyme plays role in reorganizing the paternal genome during fertilization

A sperm enters an egg, an embryo develops and eventually a baby is born. But back up a second -- how does the mother's half-genome actually merge with the father's half-genome to form one new human genome?

13 Mar 2020

Novel technique helps trace individual chromosomes during embryonic development

The spatial arrangement of genetic material within the cell nucleus plays an important role in the development of an organism.

28 Feb 2020

Penn researchers track defective sperm epigenome linked to male infertility

One out of eight couples has trouble conceiving, with nearly a quarter of those cases caused by unexplained male infertility. For the past decade, research has linked that infertility to defective sperm that fail to "evict" proteins called histones from DNA during development.

16 Dec 2019

Embryogenesis News and Research

Latest Embryogenesis News and Research

NIH awards more than $8 million to support seven high-risk, high-reward projects at Penn Medicine

Scientists create a novel cell model for understanding human development

HMGA1 plays role in gastric cancer cell proliferation and metastasis

Hedgehog-signaling inhibitor may shift tumor-associated macrophages back to cancer fighters

Eggs and embryos go through a more dynamic and complex journey than previously thought

Scientists unravel mechanisms involved in epithelial integrity

Deletion of an embryonic gene in liver cells completely wipes out bile ducts of newborn mice

Researchers determine patterns of nuclear alignment responsible for LR-asymmetrical changes in invertebrates

Researchers discover possible origin of neuroblastoma in the adrenal glands

Study shows how signaling pathways operate on molecular and cellular levels

RPS-12 protein overproduction appears to trigger breast cancer and other malignancies

Study shows neuropeptide corazonin regulates the release of diapause hormone in silkworms

Researchers explain the role of enzyme that facilitates appropriate development of mouse embryo

Researchers identify specific target sites for DNA methylases

Exploring the molecular landscape of the aortic niche and beyond

ISSCR 2020 Virtual Meeting to deliver comprehensive scientific education program

Research demonstrates control mechanism of force-induced cell-to-cell attachment

SPRK1 enzyme plays role in reorganizing the paternal genome during fertilization

Novel technique helps trace individual chromosomes during embryonic development

Penn researchers track defective sperm epigenome linked to male infertility

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

Embryogenesis News and Research

Latest Embryogenesis News and Research

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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