Epidermis News and Research

Latest Epidermis News and Research

Researchers discover mechanism that favours disappearance and inhibition of SCC development

Skin squamous cell carcinoma (SCC) is a subtype of very aggressive skin cancers that usually develops in sunexposed body regions, but can also affect a large number of organs such as the bladder, esophagus, lungs etc. However, little is known about the biology of these cells, which consequently makes difficult the generation of new specific therapies; actually, the standard treatments are based on surgery and subsequent radiotherapy.

10 Jul 2012

New insights into role and importance of exosomes and their targeted gene transcripts

In the July 6 issue of Cell Stem Cell, researchers at the University of California, San Diego School of Medicine describe how human epidermal progenitor cells and stem cells control transcription factors to avoid premature differentiation, preserving their ability to produce new skin cells throughout life.

6 Jul 2012

German BfArM grants Moberg Derma approval to initiate Limtop phase II actinic keratosis trial

The German Federal Institute for Drugs and Medical Devices (BfArM) has granted Moberg Derma approval to initiate a clinical phase II trial for Limtop. The aim is to evaluate the efficacy and safety of three different dose regimens of Limtop in a study involving 96 patients with Actinic Keratosis (AK) on the head or face.

2 May 2012

BfArM grants Moberg Derma approval to initiate Limtop clinical phase I trial for actinic keratosis

The German- Federal Institute for Drugs and Medical Devices (BfArM) has granted Moberg Derma approval to initiate a clinical phase I trial for Limtop. Limtop is an innovative formulation of an immunomodulatory compound with potential to treat actinic keratosis, genital warts and basal cell carcinoma.

11 Mar 2012

Non-invasive hyperspectral imaging system for skin cancer screening relies on Andor technology

Malignant melanoma (MM), the most dangerous type of skin cancer, is caused mainly by intense episodes of UV exposure and originates in the pigment-producing melanocytes in the basal layer of the epidermis. Early detection and complete excision of the primary lesions is crucial for reducing melanoma-related deaths but current diagnostic practice is highly subjective. This leads to unnecessary surgical procedures, which are highly-invasive and expensive.

1 Mar 2012

New combination laser therapy effective in treating melasma

On the surface, it would seem as though the skin condition melasma (commonly referred to as the "mask of pregnancy") and tattoos would have little in common. However, they both affect a person's skin, can be quite difficult to treat or remove and, now, dermatologists are discovering new laser therapies which enhance treatment for both conditions.

8 Feb 2012

Genentech receives FDA approval for Erivedge to treat basal cell carcinoma

Today, Erivedge (vismodegib) was approved by the U.S. Food and Drug Administration to treat adult patients with basal cell carcinoma, the most common type of skin cancer. The drug is intended for use in patients with locally advanced basal cell cancer who are not candidates for surgery or radiation and for patients whose cancer has spread to other parts of the body.

31 Jan 2012

Scientists decode unknown mechanism of imiquimod in tumour defense

A research team from the Institute for Cancer Research at the MedUni Vienna has decoded a previously unknown mechanism of the active ingredient imiquimod in tumour defense. They have been able to prove that imiquimod transforms plasmacytoid dendritic cells (pDCs) into "tumour-killers" which can fight the tumour independently from other immune cells. This discovery could be an important step on the way to a more efficient treatment for cancer.

20 Jan 2012

Smoking in women associated with skin cancer: Study

A new study has found a link between tobacco use and skin cancer especially in women. The study found that women who had squamous cell skin cancer were more likely to have smoked than those who were free from the disease. And those who smoked at least 20 years were twice as likely to develop squamous cell skin cancer - a less aggressive form of skin cancer as melanoma.

19 Dec 2011

Stopping necroptosis in keratinocytes prevents skin inflammation

The outer layer of the skin, called the epidermis, forms a critical physical and immunological wall that serves as the body's first line of defense against potentially harmful microorganisms. Most of the epidermis consists of cells called keratinocytes that build a mechanical barrier but also perform immune functions.

14 Oct 2011

Halozyme commences HTI-501 clinical trial for cellulite in women

Halozyme Therapeutics, Inc., a biopharmaceutical company developing and commercializing products targeting the extracellular matrix for the diabetes, cancer, dermatology and drug delivery markets, today announced the commencement of a Phase 1/2 clinical trial with HTI-501 (rHuCAT-L) in women with moderate to severe edematous fibrosclerotic panniculopathy (also known as cellulite).

28 Sep 2011

Scientists discover crucial connection in skin formation

Skin is the body's armor, protecting us from disease agents, injury, excessive water loss, and cold and heat. Yet mutations in a single gene, the gene for the protein p63, cause numerous diseases and malformations of the uppermost layer of skin - the epidermis - and other tissues. In the epidermis, these range from skin cancers to dysplasias that cause cracking, bleeding, infection, and discoloration.

21 Sep 2011

Bullet proof skin from human cells and spider silk

Dutch artist Jalila Essaidi, along with Utah State researcher Randy Lewis have made a swatch of nearly bulletproof skin made from spider silk and human skin cells. The project called “2.6g 329m/s” takes its name from the maximum weight and velocity a Type 1 bulletproof vest can withstand from a .22 calibre Long Rifle bullet.

23 Aug 2011

Researchers develop epidermal electronic system

Through a combination of careful theoretical modeling and precise micro-manufacturing, a team of engineers and scientists has developed a new type of ultra-thin, self-adhesive electronics device that can effectively measure data about the human heart, brain waves and muscle activity - all without the use of bulky equipment, conductive fluids, or glues.

12 Aug 2011

Grapes help protect skin cells from sun's UV radiation

Some compounds found in grapes help to protect skin cells from the sun's ultraviolet radiation, according to a study by researchers from the University of Barcelona and the CSIC.

29 Jul 2011

Invadopodia could help survival of cancer cells

Delicate, threadlike protrusions used by cancer cells when they invade other tissues in the body could also help them escape control mechanisms supposed to eliminate them, a research group led by led by Bradley Davidson in the University of Arizona's department of molecular and cellular biology reports in Nature Cell Biology.

28 Jul 2011

Beta HPV prophylactic strategies may have a positive impact on prevention of NMSC

Non-melanoma skin cancer is the most common form of malignancy in adult Caucasian populations, with more than a million cases recorded each year in the USA alone.

21 Jul 2011

Cynosure announces acquisition of HOYA ConBio's aesthetic laser business

Building on its reputation as a global technology leader in laser and light-based aesthetic systems, Cynosure, Inc. today announced that it has acquired the assets of the aesthetic laser business of HOYA ConBio, a wholly owned subsidiary of Japan-based HOYA Corporation, for $24.5 million in cash. HOYA ConBio is based in Fremont, California.

28 Jun 2011

Phytoceuticals to present promising clinical data on 1 PRIMARY WOUND DRESSING at EWMA 2011

Phytoceuticals Ltd. will present promising clinical and scientific data on 1 PRIMARY WOUND DRESSING at the 2011 EWMA Conference on May 26, the largest European wound management conference.

23 May 2011

'Gatekeeper' protein plays a key role in skin-cancer prevention

New research from North Carolina State University shows that a "gatekeeper" protein plays an important role in skin-cancer prevention in humans and lab mice.

19 May 2011