Gene News and Research

Latest Gene News and Research

Study identifies mechanism of resistance and presents a much-needed target for advanced leukemias

Too many "exhausted" T cells left in the wake of aggressive chemotherapy regimens for patients with advanced chronic lymphocytic leukemia (CLL) make it more challenging for chimeric antigen receptor (CAR) T cell therapy to do its job.

16 Aug 2021

Researchers assess the genetic features of T-cell immunity development to SARS-CoV-2 variants

The continuing emergence of new SARS-CoV-2 mutations allows the virus to spread more effectively and evade antibodies. However, it is unclear whether new strains are capable of evading T-cell immunity - one of the body's main lines of defense against COVID-19.

16 Aug 2021

Enzyme acts as a sensor to find the hiding spots of viruses

While some types of RNA viruses cloak themselves to hide inside a cell and create copies of themselves, a "detective enzyme" might be attuned to their whereabouts. A slight variation in their genomic code gives some people's cells the capacity to produce this sensor.

14 Aug 2021

Study illuminates the link between cholesterol and Alzheimer's-associated toxic protein clumps

A team co-led by scientists at Scripps Research has used advanced imaging methods to reveal how the production of the Alzheimer's-associated protein amyloid beta (Aβ) in the brain is tightly regulated by cholesterol.

13 Aug 2021

Structure of BRCA2 protein complex critical for DNA repair solved

The initials BRCA2 may be best known for a gene associated with many cases of breast cancer, and the protein encoded by the BRCA2 gene is critical to repairing breaks in DNA.

13 Aug 2021

Novel CRISPR-based technique could inspire a new class of medical diagnostics

Scientists have repurposed the genetic modification technology CRISPR to identify antibodies in patient blood samples in a move that could inspire a new class of medical diagnostics in addition to a host of other applications.

13 Aug 2021

Specific leukemia gene mutations exert divergent effects on DNA repair and sensitivity to PARP Inhibitors

In a recent study published in Cancer Research, researchers from Fels Cancer Institute for Personalized Medicine at the Lewis Katz School of Medicine at Temple University and Fox Chase Cancer Center identified specific leukemia gene mutations and the mechanisms by which they regulate DNA repair and respond to PARP inhibitors.

13 Aug 2021

Study uncovers a subset of human short introns spliced out by a distinct mechanism

The interrupted non-coding regions in pre-mRNAs, termed “introns,” are excised by “splicing” to generate mature coding mRNAs that are translated into proteins.

13 Aug 2021

Researchers identify genetic program in fruit fly that protects neurons from degeneration

Researchers at the University of Bonn have identified a previously unknown genetic program in the fruit fly. The genetic material involved controls the development of the neurons while also protecting them from degeneration.

13 Aug 2021

How replication and recombination contribute to emergence of SARS-CoV-2 variants

The coronavirus disease 2019 (COVID-19) pandemic has been caused by the rapid outbreak of a novel coronavirus, namely, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). SARS-CoV-2 was first reported in late December 2019 in Wuhan, China. Since then, the virus has already claimed more than 4.3 million lives worldwide.

13 Aug 2021

Innovative therapeutic platform for blood-to-brain delivery of antisense oligonucleotide therapy

Antisense oligonucleotide (ASO) therapy has the potential to ameliorate many neurodegenerative diseases at the genetic level to suppress the production of harmful proteins or non-coding RNAs.

12 Aug 2021

Immunotherapy pairs ultrasound with immune cells to destroy tumors without toxic side effects

Bioengineers at the University of California San Diego have developed a cancer immunotherapy that pairs ultrasound with cancer-killing immune cells to destroy malignant tumors while sparing normal tissue.

12 Aug 2021

Targeting a skin protein may reduce the severity of psoriasis, study reveals

Results from a Michigan Medicine study reveal that targeting a protein found in the skin may reduce the severity of psoriasis.

12 Aug 2021

Study finds new pair of gene variants that causes sudden onset of hypertension in pregnant women

An international study, led by researchers from Queen Mary University of London and St Bartholomew's Hospital, has found a unique pair of gene variants that causes sudden onset high blood pressure in pregnant women.

12 Aug 2021

Study unlocks genetic treasure chest for chronic kidney disease

Despite impacting an estimated 850 million people and being responsible for 1 in 60 deaths worldwide, few treatments are available for chronic kidney disease.

12 Aug 2021

UC San Diego scientists develop new method to keep cultured cells healthy

Hematopoietic stem cells — the precursors to blood cells — have been notoriously difficult to grow in a dish, a critical tool in basic research.

12 Aug 2021

VPS29 gene facilitates coronavirus cell entry

In a research paper recently uploaded to the bioRxiv* preprint server by Poston et al. (August 8th, 2021), common host factors amongst several zoonotic pathogens are explored by CRISPR-Cas9 screening in human lung cells, focusing in particular on the betacoronavirus genus.

11 Aug 2021

Understanding hypoxia-induced gene expression variations in aggressive type of pancreatic cancer

Cancer cells have evolved a myriad of mechanisms that support their uncontrolled growth. In case of solid tissue tumors, the tumor microenvironment, which consists of extracellular components and conditions surrounding the tumor, is crucial in deciding the fate of the cancer cells.

11 Aug 2021

Researchers aim to identify gene-lifestyle interactions that contribute to cardiometabolic disease risk

Researchers at Washington University School of Medicine in St. Louis have received a four-year, $8.8 million grant to ramp up research aimed at unraveling how an individual's risks of cardiometabolic diseases, such as heart disease and Type 2 diabetes, are influenced by the interaction of specific genes with demographic and lifestyle factors.

11 Aug 2021

Mount Sinai study discovers an important clue to multisystem inflammatory syndrome in children

Mount Sinai researchers have found an important clue to a rare but serious aftereffect of COVID-19 in children, known as a multisystem inflammatory syndrome in children or MIS-C.

11 Aug 2021

Gene News and Research

Latest Gene News and Research

Study identifies mechanism of resistance and presents a much-needed target for advanced leukemias

Researchers assess the genetic features of T-cell immunity development to SARS-CoV-2 variants

Enzyme acts as a sensor to find the hiding spots of viruses

Study illuminates the link between cholesterol and Alzheimer's-associated toxic protein clumps

Structure of BRCA2 protein complex critical for DNA repair solved

Novel CRISPR-based technique could inspire a new class of medical diagnostics

Specific leukemia gene mutations exert divergent effects on DNA repair and sensitivity to PARP Inhibitors

Study uncovers a subset of human short introns spliced out by a distinct mechanism

Researchers identify genetic program in fruit fly that protects neurons from degeneration

How replication and recombination contribute to emergence of SARS-CoV-2 variants

Innovative therapeutic platform for blood-to-brain delivery of antisense oligonucleotide therapy

Immunotherapy pairs ultrasound with immune cells to destroy tumors without toxic side effects

Targeting a skin protein may reduce the severity of psoriasis, study reveals

Study finds new pair of gene variants that causes sudden onset of hypertension in pregnant women

Study unlocks genetic treasure chest for chronic kidney disease

UC San Diego scientists develop new method to keep cultured cells healthy

VPS29 gene facilitates coronavirus cell entry

Understanding hypoxia-induced gene expression variations in aggressive type of pancreatic cancer

Researchers aim to identify gene-lifestyle interactions that contribute to cardiometabolic disease risk

Mount Sinai study discovers an important clue to multisystem inflammatory syndrome in children

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging