Gene News and Research

Latest Gene News and Research

Studies reveal the promise of newly engineered bispecific antibodies against tumor cells

Three studies - one each in Science, Science Translational Medicine, and Science Immunology - reveal the promise of newly engineered bispecific antibodies, including by demonstrating their power against previously inaccessible tumor cell targets for the first time, in two cases.

2 Mar 2021

A single letter difference in a single gene spells a lifetime of anemia, pain worldwide

A single letter difference in a single gene, inherited from both parents, spells a lifetime of anemia and pain for 20 million people, mostly of African ancestry, worldwide.

2 Mar 2021

Researchers explore early stages of ribosome formation to identify new targets for antibiotics

Ribosome formation is viewed as a promising potential target for new antibacterial agents. Researchers from Charité - Universitätsmedizin Berlin have gained new insights into this multifaceted process.

2 Mar 2021

Loss of functions in the PLD1 gene causes congenital heart disease

A team of researchers co-led by Michael Frohman, MD, PhD, of Stony Brook University, has identified an important cause of congenital heart disease.

2 Mar 2021

Unique nanoparticles can package and deliver gene-editing machinery to the liver

The genome editing technology CRISPR has emerged as a powerful new tool that can change the way we treat disease. The challenge when altering the genetics of our cells, however, is how to do it safely, effectively, and specifically targeted to the gene, tissue and organ that needs treatment.

2 Mar 2021

Study shows asthma mediator IL-13 prevents SARS-CoV-2 infection

In a paper published on the bioRxiv preprint server, researchers reported the results on whether IL-13 expression in asthma patients reduces their susceptibility to SARS-CoV-2 infection.

1 Mar 2021

Newly discovered protein regulates molecular motors in response to light

Single-celled algae and animal sperm cells are widely separated in evolution but both swim in the same way, by waving their protruding hairs, called cilia or flagella. Motion is driven by molecular motors, complex assemblies of proteins that exert a force when changing shape.

1 Mar 2021

Scientists establish infection models for SARS-CoV-2 UK & South African variants

New research suggests Syrian golden hamsters could be a potentially useful preclinical model for testing vaccine immunity against the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.17 and B.1.351 variant.

1 Mar 2021

Lung cancer cells activate different signaling pathways in response to KRAS inhibitors

Genetic alterations of the KRAS gene are some of the most common mutations in lung cancer patients, but unfortunately these patients have few effective treatment options.

1 Mar 2021

New technique uncovers the tricks used by cancer cells to evade immunotherapies

By harnessing the immune system against cancer, immunotherapies have revolutionized the way some types of cancer are treated. But most patients--across cancer types--do not respond, and in most cases, scientists are at a loss as to why.

1 Mar 2021

A region within GLI1 gene could potentially be targeted as cancer treatment

Scientists from the Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago found that a region within the DNA of the cancer-promoting GLI1 gene is directly responsible for regulating this gene's expression.

1 Mar 2021

Researchers develop mutant gene-targeted immunotherapy approach to fight cancers

A novel targeted immunotherapy approach developed by researchers at the Ludwig Center, the Lustgarten Laboratory, and Bloomberg~Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center employs new antibodies against genetically altered proteins to target cancers.

1 Mar 2021

Exposure to periods of low oxygen can result in underdeveloped jaw cartilage

Breathing in adequate amounts of oxygen is critical for human life. However, certain disorders can cause individuals to go through periods where they are exposed to periodical low levels of oxygen, called intermittent hypoxia (IH).

1 Mar 2021

ACGT awards $500,000 to advance immunotherapy approach for treating solid tumors

A scientific team led by Brian Brown, PhD, Professor of Genetics and Genomic Sciences and Associate Director of the Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai (New York, New York), has been awarded $500,000 from Alliance for Cancer Gene Therapy to advance a promising immunotherapy approach to fight lung cancer and other solid tumor cancers.

1 Mar 2021

New method boosts research efforts to eradicate cancer at its source

A new method, described in a study published today in the journal Nature Communications, has the potential to boost international research efforts to find drugs that eradicate cancer at its source.

1 Mar 2021

Deep learning-based splice-AI can help predict the onset of Alzheimer's disease

Korea Brain Research Institute (KBRI, President Suh Pann-ghill) announced that the research team led by Dr. Jae-Yeol Joo discovered new cryptic splice variants and SNVs in PLCg1 gene of AD-specific models for the first time using Splice-AI.

1 Mar 2021

Commonly used sweeteners may promote antibiotic resistance

Researchers in Australia have conducted a study showing that commonly used nonnutritive sweeteners can promote the spread of antibiotic-resistant genes in the intestine.

28 Feb 2021

Efficacy of polymeric nano-micelles depends on expression level of c-Myc

The Innovation Center of NanoMedicine (Director General: Prof. Kazunori Kataoka, Location: Kawasaki in Japan, Abbreviation: iCONM) reported in ACS Nano (Impact Factor: 14.588 in 2019) together with the group of Prof. Yu Matsumoto of Otorhinolaryngology and Head and Neck Surgery (Prof. Tatsuya Yamasoba) and the group of Prof. Horacio Cabral of the Department of Bioengineering (Prof. Ryo Miyake) in the University of Tokyo that the efficacy of polymeric nano-micelles with different drug activation profile depends on the expression level of c-Myc, one of the major proto-oncogene, has been developed.

27 Feb 2021

MicroRNAs predict heart and kidney health in children without disease

Molecules called microRNAs (miRNAs) that are measurable in urine have been identified by researchers at Mount Sinai as predictors of both heart and kidney health in children without disease.

27 Feb 2021

Diverse patient population helps identify gene variant associated with childhood asthma

Researchers at Henry Ford Health System, as part of a national asthma collaborative, have identified a gene variant associated with childhood asthma that underscores the importance of including diverse patient populations in research studies.

27 Feb 2021

Gene News and Research

Latest Gene News and Research

Studies reveal the promise of newly engineered bispecific antibodies against tumor cells

A single letter difference in a single gene spells a lifetime of anemia, pain worldwide

Researchers explore early stages of ribosome formation to identify new targets for antibiotics

Loss of functions in the PLD1 gene causes congenital heart disease

Unique nanoparticles can package and deliver gene-editing machinery to the liver

Study shows asthma mediator IL-13 prevents SARS-CoV-2 infection

Newly discovered protein regulates molecular motors in response to light

Scientists establish infection models for SARS-CoV-2 UK & South African variants

Lung cancer cells activate different signaling pathways in response to KRAS inhibitors

New technique uncovers the tricks used by cancer cells to evade immunotherapies

A region within GLI1 gene could potentially be targeted as cancer treatment

Researchers develop mutant gene-targeted immunotherapy approach to fight cancers

Exposure to periods of low oxygen can result in underdeveloped jaw cartilage

ACGT awards $500,000 to advance immunotherapy approach for treating solid tumors

New method boosts research efforts to eradicate cancer at its source

Deep learning-based splice-AI can help predict the onset of Alzheimer's disease

Commonly used sweeteners may promote antibiotic resistance

Efficacy of polymeric nano-micelles depends on expression level of c-Myc

MicroRNAs predict heart and kidney health in children without disease

Diverse patient population helps identify gene variant associated with childhood asthma

eBook: Using iPSCs models for human disease research and drug discovery eBook

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging