Gene News and Research

Latest Gene News and Research

Study offers new insight into genetic alterations associated with osteosarcoma

A study by researchers at the National Cancer Institute, part of the National Institutes of Health, offers new insight into genetic alterations associated with osteosarcoma, the most common cancerous bone tumor of children and adolescents.

19 Mar 2020

Researchers uncover molecular events underlying paternal diet-induced metabolic disorders in children

When parents eat low-protein or high-fat diets it can lead to metabolic disorders in their adult offspring. Now, an international team led by researchers at the RIKEN Cluster for Pioneering Research have identified a key player and the molecular events underlying this phenomenon in mice.

19 Mar 2020

Study helps predict which ovarian cancer patients will not benefit from immune-PARP combo

In patients with advanced ovarian cancer, a combination of drugs known as immune checkpoint inhibitors and PARP inhibitors can produce powerful remissions, clinical trials have shown, but up until now investigators haven't been able to predict which patients won't benefit from the treatment and should explore other options.

19 Mar 2020

Study paves way for identifying ovarian cancer patients who will not benefit from combination therapy

A study suggests it may be possible to identify those who will not benefit from drug combination for advanced ovarian cancer.

19 Mar 2020

Bacteria-trapping protein may contribute to breast cancer metastasis

The protein peptidyl arginine deiminase 4 (PAD4), which enables some immune cells to trap bacteria, promoted breast cancer metastasis in mice when expressed in cancer cells, according to data published in Molecular Cancer Research, a journal of the American Association for Cancer Research.

19 Mar 2020

Identification of 'Hodor' in the gut lining highlights potential way to curb mosquito populations

The identification of an insect-specific metal-sensing receptor in the gut lining highlights a possible new way to curb populations of disease-transmitting insects such as mosquitoes.

18 Mar 2020

High-throughput screening of AAV vector capsid libraries reveals unexpected insights

Researchers have used high-throughput screening of adeno-associated viral (AAV) vector capsid libraries to maximize the likelihood of obtaining AAV variants with desired properties.

18 Mar 2020

Drug from scorpion venom could offer hope for children with fetal alcohol spectrum disorder

A research team led by Children's National Hospital faculty was able to "rescue" a pre-clinical model of fetal alcohol spectrum disorder in juvenile models, reversing motor skill deficits with the help of a novel drug derived from scorpion venom.

18 Mar 2020

Researchers identify new way to treat Danon disease using gene therapy

Danon disease is a very rare, life-threatening condition where the fundamental biological process of removing and recycling proteins does not work.

18 Mar 2020

Using 'organs-on-a-chip' to study chronic inflammatory diseases

MIT biological engineers have created a multitissue model that lets them study the relationships between different organs and the immune system, on a specialized microfluidic platform seeded with human cells.

18 Mar 2020

Bacterial extracellular vesicles could combat antibiotic resistance

Children's National Hospital researchers for the first time have isolated bacterial extracellular vesicles from the blood of healthy donors, a critical step to better understanding the way gut bacteria communicate with the rest of the body via the bloodstream.

18 Mar 2020

Novel Alzheimer's risk genes affect microglial response to amyloid-beta

Our DNA determines a large part of our risk for Alzheimer's disease, but it remained unclear how many genetic risk factors contribute to disease.

18 Mar 2020

High iron levels in lung increase severity of asthma

A new study published in the European Respiratory Journal in March 2020 reports that the accumulation of iron in the cells of the lung exacerbates asthma symptoms and reduces lung function.

17 Mar 2020

Researchers identify genetic signature linked to higher risk of preeclampsia

Researchers at Baylor College of Medicine have identified a genetic signature combining certain maternal and fetal gene variants that are associated with a higher risk of preeclampsia.

17 Mar 2020

EHD2 protein plays a key role in fat metabolism

Many foods - whether it's the mozzarella on your favorite pizza, the olive oil in salad dressing or hollandaise sauce during asparagus season - contain lots of fat. The fatty acids in these foods are among the essential nutrients that people need to survive.

17 Mar 2020

Researchers elucidate new mechanism for controlling DNA methylation in cells

Why normal cells turn into cancer cells One of the factors is deeply related to the failure of the cell differentiation mechanism called DNA methylation.

17 Mar 2020

Antioxidant treatment in acute ischemic stroke could delay onset of clinically overt dementia

Currently we are facing a dementia epidemic, with estimations showing that by 2050 approximately 131 million people will be affected.

17 Mar 2020

Recognizing CDKL5 Deficiency Disorder

News-Medical speaks to Dr. Dan Lavery about the LouLou Foundation, a non-profit organization dedicated to CDLK5 Deficiency Disorder.

17 Mar 2020

Increased competition between males can lead to higher rate of harmful mutations in offspring

Males that face tougher competition for females risk having offspring with a greater number of harmful mutations in their genome than males without rivals.

16 Mar 2020

Trial of cancer drug OxaliTex promises lower toxicity and more robust action

Preclinical trials indicate that a drug candidate called OxaliTex can stop the growth of cancer cells completely. OxaliTex appears to be more potent than many other common chemotherapy drugs, with less toxicity and less rapidly counteracted by mechanisms of drug resistance. The study was reported in the journal Proceedings of the National Academy of Sciences in March 2020.

16 Mar 2020

Gene News and Research

Latest Gene News and Research

Study offers new insight into genetic alterations associated with osteosarcoma

Researchers uncover molecular events underlying paternal diet-induced metabolic disorders in children

Study helps predict which ovarian cancer patients will not benefit from immune-PARP combo

Study paves way for identifying ovarian cancer patients who will not benefit from combination therapy

Bacteria-trapping protein may contribute to breast cancer metastasis

Identification of 'Hodor' in the gut lining highlights potential way to curb mosquito populations

High-throughput screening of AAV vector capsid libraries reveals unexpected insights

Drug from scorpion venom could offer hope for children with fetal alcohol spectrum disorder

Researchers identify new way to treat Danon disease using gene therapy

Using 'organs-on-a-chip' to study chronic inflammatory diseases

Bacterial extracellular vesicles could combat antibiotic resistance

Novel Alzheimer's risk genes affect microglial response to amyloid-beta

High iron levels in lung increase severity of asthma

Researchers identify genetic signature linked to higher risk of preeclampsia

EHD2 protein plays a key role in fat metabolism

Researchers elucidate new mechanism for controlling DNA methylation in cells

Antioxidant treatment in acute ischemic stroke could delay onset of clinically overt dementia

Recognizing CDKL5 Deficiency Disorder

Increased competition between males can lead to higher rate of harmful mutations in offspring

Trial of cancer drug OxaliTex promises lower toxicity and more robust action

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Exploring the nanoscale: How AFM is transforming cosmetic science

Innovating Texture and Culture in Plant-Based Foods

Advancing brain microphysiological systems (bMPS)