Gene News and Research

Latest Gene News and Research

Study finds new clues to understand relapse in breast cancer

A large genomic analysis has linked certain DNA mutations to a high risk of relapse in estrogen receptor positive breast cancer, while other mutations were associated with better outcomes, according to researchers from Washington University School of Medicine in St. Louis, the Baylor College of Medicine and the University of British Columbia.

4 Sep 2018

Easy and inexpensive test could one day help guide epilepsy treatment

An easy and inexpensive test for the HLA-B*15:02 allele could one day allow clinicians to quickly identify which epilepsy patients are at risk of carbamazepine hypersensitivity, according to study results presented by Gita V. Soraya at ILAE's 2018 Asian & Oceanian Epilepsy Congress in Bali.

4 Sep 2018

Study provides absolute 10-year estimates for dementia by age, sex and APOE genotype

A Danish study provides 10-year absolute risk estimates for dementia specific to age, sex and common variation in the APOE gene, which may help identify high-risk individuals who potentially could benefit from early targeted prevention.

4 Sep 2018

Stanford researchers show how to prevent immune response to gene therapy in mouse model

Stanford University School of Medicine researchers have demonstrated that gene therapy can be effective without causing a dangerous side effect common to all gene therapy: an autoimmune reaction to the normal protein, which the patient's immune system is encountering for the first time.

4 Sep 2018

Study sheds light on how vaso-occlusive pain crises arise in sickle-cell disease

One of the most common complications of sickle-cell disease occurs when deformed red blood cells clump together, blocking tiny blood vessels and causing severe pain and swelling in the affected body parts.

4 Sep 2018

Gene editing could prevent the evolution of drug-resistant bacteria

Researchers have found a way of preventing the emergence of antibiotic-resistant bacteria, a promising new discovery in the fight against deadly superbugs.

3 Sep 2018

Genetic disruption strategy effectively stymies evolution of drug-resistant pathogens

A genetic disruption strategy developed by University of Colorado Boulder researchers effectively stymies the evolution of antibiotic-resistant bacteria such as E. coli, giving scientists a crucial leg up in the ongoing battle against deadly superbugs.

3 Sep 2018

Breakthrough study sheds light on mechanism underlying Warsaw Breakage Syndrome

Researchers from Tokyo Metropolitan University and the FIRC Institute of Molecular Oncology in Italy have uncovered a previously unknown function of the DDX11 helicase enzyme.

3 Sep 2018

Severity of asthma depends on genetic profile and air pollution

Asthma patients, with a specific genetic profile, exhibit more intense symptoms following exposure to traffic pollution, according to researchers at the National Institutes of Health and collaborators. The study appeared online in Scientific Reports.

31 Aug 2018

A genetic signal-transmission system for the gut microbiome

More than 1,000 species of bacteria have been identified in the human gut, and understanding this incredibly diverse "microbiome" that can greatly impact health and disease is a hot topic in scientific research.

31 Aug 2018

Arrowhead completes dosing of ARO-AAT Phase 1 study to treat rare genetic liver disease

Arrowhead Pharmaceuticals Inc. today announced that it has completed dosing of a Phase 1 clinical study of ARO-AAT, the company's second generation subcutaneously administered RNA interference therapeutic being developed as a treatment for a rare genetic liver disease associated with alpha-1 antitrypsin deficiency.

31 Aug 2018

Study reveals mechanisms underlying inflammatory response in the brain associated with fever

Researchers from Kanazawa University report in Journal of Neuroscience performed a microdialysis study on mice to determine mechanisms underlying the inflammatory response in the brain associated with fever that might be used to develop new strategies for treatment.

31 Aug 2018

Researchers predict how splicing errors impact disease risk

No one knows how many times in a day, or even an hour, the trillions of cells in our body need to make proteins.

31 Aug 2018

Research may hold key to unlocking cause and finding treatment for age-related hearing loss

Age-related hearing loss is among the top three chronic conditions affecting adults 65 years or older, according to the National Center for Health Statistics.

31 Aug 2018

Muscle dystrophy treatment in dogs with Crispr gene editing

Researchers in the United States have shown that genetically caused muscular dystrophy in dogs could be corrected using genetic editing tools. Muscular dystrophy is one of the most common fatal genetic conditions seen in children and is also seen in dogs

31 Aug 2018

Study raises possibility of detecting childhood bone cancers earlier

Scientists have discovered that some childhood bone cancers start growing years before they are currently diagnosed.

30 Aug 2018

New genetic marker could improve diagnosis of prostate cancer

Scientists have discovered a link between certain genetic mutations, the aggressiveness of prostate cancer, risk of developing the disease and poorer survival rates of patients.

30 Aug 2018

Pfizer terminates clinical studies evaluating domagrozumab for treatment of Duchenne muscular dystrophy

Pfizer Inc. announced today that it is terminating two ongoing clinical studies evaluating domagrozumab (PF-06252616) for the treatment of Duchenne muscular dystrophy (DMD): a Phase 2 safety and efficacy study (B5161002) and an open-label extension study (B5161004).

30 Aug 2018

EC grants marketing authorization for ONPATTRO (patisiran) in Europe

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today that the European Commission (EC) has granted marketing authorization for ONPATTRO (patisiran) for the treatment of hereditary transthyretin-mediated (hATTR) amyloidosis in adults with stage 1 or stage 2 polyneuropathy.

30 Aug 2018

Study yields therapeutic clues to combat drug resistance in rare aggressive cancer

Stephen Elledge, PhD, and his team did not set out to find therapies that could render tumors less resistant to therapy or make existing drugs more potent against a rare form of cancer. But these are precisely the clinical insights that their most recent study has yielded.

29 Aug 2018

Gene News and Research

Latest Gene News and Research

Study finds new clues to understand relapse in breast cancer

Easy and inexpensive test could one day help guide epilepsy treatment

Study provides absolute 10-year estimates for dementia by age, sex and APOE genotype

Stanford researchers show how to prevent immune response to gene therapy in mouse model

Study sheds light on how vaso-occlusive pain crises arise in sickle-cell disease

Gene editing could prevent the evolution of drug-resistant bacteria

Genetic disruption strategy effectively stymies evolution of drug-resistant pathogens

Breakthrough study sheds light on mechanism underlying Warsaw Breakage Syndrome

Severity of asthma depends on genetic profile and air pollution

A genetic signal-transmission system for the gut microbiome

Arrowhead completes dosing of ARO-AAT Phase 1 study to treat rare genetic liver disease

Study reveals mechanisms underlying inflammatory response in the brain associated with fever

Researchers predict how splicing errors impact disease risk

Research may hold key to unlocking cause and finding treatment for age-related hearing loss

Muscle dystrophy treatment in dogs with Crispr gene editing

Study raises possibility of detecting childhood bone cancers earlier

New genetic marker could improve diagnosis of prostate cancer

Pfizer terminates clinical studies evaluating domagrozumab for treatment of Duchenne muscular dystrophy

EC grants marketing authorization for ONPATTRO (patisiran) in Europe

Study yields therapeutic clues to combat drug resistance in rare aggressive cancer

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